Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bortezomib | Proteasome | Proteasome | 0.0169 | 0.0283 | 0.0758 | -0.9074 | -0.8026 | -0.7299 | -0.9162 | -0.8011 | -0.7357 | 1.1703 | 1.8347 | 2.7508 | 0.9093 | 1.0406 | 1.1781 | 0.0266 | 0.0496 | 0.1485 | |
| Ixabepilone | TUBB | TUBB | 0.0045 | 0.0114 | 0.0487 | -0.9765 | -0.9460 | -0.8485 | -0.9892 | -0.7196 | -0.5742 | 0.3937 | 0.7623 | 1.6684 | 0.6842 | 0.8505 | 0.9658 | 0.0102 | 0.0892 | 0.7025 | |
| Torkinib | MTOR | MTOR | 0.0008 | 0.0021 | 0.0184 | -0.5713 | -0.3826 | -0.2014 | -0.6715 | -0.4047 | -0.1504 | 0.3324 | 0.3720 | 0.5454 | 0.6694 | 0.8411 | 1.0104 | 0.0046 | 0.0211 | 0.0646 | |
| MG-132 | Proteasome | Proteasome | 0.1071 | 0.1768 | 0.5078 | -0.8632 | -0.7505 | -0.5413 | -0.8499 | -0.6667 | -0.5123 | 1.5044 | 2.4128 | 3.5768 | 0.6530 | 0.7329 | 0.8677 | 0.1559 | 0.2469 | 1.0059 | |
| Trichostatin A | HDAC | HDAC | 6.5374 | 11.5225 | 17.5553 | -0.9202 | -0.8512 | -0.7541 | -0.9053 | -0.8178 | -0.6756 | 1.3647 | 1.8955 | 2.2777 | 0.6490 | 0.7724 | 0.9158 | 11.0302 | 20.2024 | 30.2620 | |
| Geldanamycin | HSP90 | HSP90 | 0.0092 | 0.0240 | 0.0425 | -0.4324 | -0.2962 | -0.0904 | -0.3507 | -0.2347 | -0.0323 | 1.6732 | 2.3748 | 3.3908 | 0.6486 | 0.7709 | 0.9035 | 0.0116 | 0.0269 | 0.0560 | |
| Omipalisib | PI3K | PI3K | 0.0049 | 0.0154 | 0.0397 | -0.8281 | -0.5752 | -0.4164 | -0.8004 | -0.5070 | -0.2908 | 0.6200 | 0.7592 | 0.9464 | 0.6332 | 0.8101 | 0.9689 | 0.0158 | 0.0370 | 0.0945 | |
| Vinorelbine | TUBB | TUBB | 0.0079 | 0.0130 | 0.0470 | -0.9358 | -0.8653 | -0.6758 | -1.0000 | -0.5683 | -0.3360 | 0.3815 | 2.2644 | 3.6055 | 0.6197 | 0.8320 | 1.0409 | 0.0132 | 0.0302 | 0.9743 | |
| Epirubicin | TOP2 | TOP | 0.2120 | 0.3019 | 0.4930 | -0.9915 | -0.9463 | -0.8152 | -0.8492 | -0.7437 | -0.6556 | 0.9325 | 1.4047 | 2.1457 | 0.6134 | 0.7438 | 0.8467 | 0.3985 | 0.6015 | 1.3650 | |
| Fascaplysin | CDK4 | CDK | 0.1734 | 0.2805 | 0.3987 | -0.9809 | -0.9546 | -0.8701 | -0.9898 | -0.9538 | -0.8570 | 1.9348 | 2.3235 | 2.8230 | 0.5843 | 0.6643 | 0.7626 | 0.3281 | 0.4110 | 0.6267 | |
| Topotecan | TOP1 | TOP | 0.0324 | 0.1223 | 0.4672 | -0.7615 | -0.5906 | -0.2740 | -0.8265 | -0.6901 | -0.4582 | 0.5573 | 0.7931 | 1.1373 | 0.5801 | 0.7088 | 0.8375 | 0.0774 | 0.7078 | 1.2170 | |
| NSC 663284 | CDC25 | CDC | 1.6689 | 2.2519 | 3.0742 | -0.9668 | -0.9336 | -0.8607 | -0.9846 | -0.9413 | -0.8554 | 1.8405 | 2.5456 | 4.2988 | 0.5484 | 0.5805 | 0.6318 | 2.2603 | 3.4718 | 5.7633 | |
| LBH589 | HDAC | HDAC | 0.0792 | 0.1432 | 0.2719 | -0.9159 | -0.8072 | -0.7128 | -0.9155 | -0.7955 | -0.6832 | 1.1720 | 1.5004 | 2.1649 | 0.5471 | 0.6739 | 0.7846 | 0.1472 | 0.2600 | 0.4626 | |
| Taxol | TUBB | TUBB | 0.0078 | 0.0104 | 0.0155 | -0.5505 | -0.2204 | 0.0319 | -0.5168 | -0.1393 | 0.1113 | 1.6357 | 2.0915 | 3.1238 | 0.5399 | 0.6855 | 0.9358 | 0.0096 | 0.0111 | 0.0153 | |
| Ispinesib | KSP | Kinesin | 0.0263 | 0.0439 | 0.1261 | -0.9817 | -0.9567 | -0.8688 | -1.0000 | -0.9800 | -0.6258 | 0.4997 | 1.2912 | 3.1780 | 0.5293 | 0.6720 | 0.8104 | 0.0357 | 0.4315 | 1.3590 | |
| Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.4036 | 0.5478 | 1.0248 | -0.8567 | -0.7928 | -0.6682 | -0.8570 | -0.7958 | -0.6543 | 1.7769 | 2.1873 | 3.5139 | 0.5265 | 0.6392 | 0.6811 | 0.6073 | 0.7378 | 1.6091 | |
| Doxorubicin | TOP2 | TOP | 0.1488 | 0.2099 | 0.7023 | -0.9456 | -0.8552 | -0.5483 | -0.8723 | -0.7083 | -0.3772 | 1.0561 | 1.4782 | 2.5260 | 0.5209 | 0.6697 | 0.8073 | 0.2444 | 0.4713 | 1.2126 | |
| Docetaxel | TUBB | TUBB | 0.0022 | 0.0051 | 0.0098 | -0.3944 | -0.0464 | 0.1697 | -0.4257 | -0.0477 | 0.1373 | 1.4024 | 1.6746 | 2.3040 | 0.4979 | 0.6215 | 0.8198 | 0.0027 | 0.0049 | 0.0080 | |
| Vorinostat | HDAC | HDAC | 72.1503 | 100.0000 | 100.0000 | -0.8970 | -0.8099 | -0.5591 | -0.9320 | -0.8403 | -0.5970 | 1.0273 | 1.3201 | 1.6251 | 0.4794 | 0.5820 | 0.7389 | 100.0000 | 100.0000 | 100.0000 | |
| 17-AAG | HSP90 | HSP90 | 0.0442 | 0.0876 | 0.1713 | -0.7309 | -0.6010 | -0.3062 | -0.5924 | -0.4000 | -0.2370 | 0.8987 | 1.8748 | 3.3051 | 0.4754 | 0.6987 | 0.8282 | 0.0680 | 0.1218 | 0.3890 | |
| GSK461364 | PLK1 | PLK | 0.0087 | 0.0183 | 0.0805 | -0.6111 | -0.4222 | -0.2111 | -0.4745 | -0.3080 | -0.0919 | 2.4728 | 2.7172 | 4.9263 | 0.4701 | 0.6125 | 0.7345 | 0.0105 | 0.0265 | 0.3325 | |
| Afatinib | EGFR/HER2 | ErbB | 0.1253 | 1.5517 | 2.4757 | -0.9553 | -0.9200 | -0.8460 | -1.0000 | -1.0000 | -0.9391 | 0.5080 | 1.0283 | 1.7263 | 0.4620 | 0.5435 | 0.6679 | 1.1116 | 3.3143 | 4.9447 | |
| Oxamflatin | HDAC | HDAC | 0.6664 | 0.9513 | 1.6592 | -0.9525 | -0.8858 | -0.8199 | -1.0000 | -0.9857 | -0.8929 | 1.0334 | 1.2610 | 1.4776 | 0.4375 | 0.5175 | 0.6006 | 1.6681 | 2.6703 | 3.8183 | |
| Oxaliplatin | DNA cross-linker | DNA cross-linker | 3.2681 | 4.9333 | 12.0662 | -0.9391 | -0.8084 | -0.7104 | -1.0000 | -1.0000 | -0.9516 | 0.6228 | 0.7486 | 1.0057 | 0.4005 | 0.5419 | 0.5768 | 14.7918 | 22.6957 | 42.6124 | |
| Imatinib | ABL/KIT/PDGFR | nRTK | 18.5481 | 21.7914 | 25.5570 | -0.9852 | -0.9632 | -0.8948 | -0.9969 | -0.9814 | -0.8936 | 2.2328 | 2.7060 | 3.3541 | 0.3997 | 0.4467 | 0.4851 | 27.9144 | 31.9309 | 36.9254 |