Topotecan - Small Molecule (ID:10278-999)

HMS LINCS ID: 10278-999
Name: Topotecan
Alternative Names: Hycamtin
LINCS ID: LSM-5662
PubChem CID: 60700
ChEBI ID:
ChEMBL ID:
Molecular Mass: 421.16
InChi: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChi Key: UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
HIF1A
2
(equivalent to 100 nM ≤ Kd < 1µM)
TOP1
10
(confirmed non-binding)

Batch Information for HMSL10278-999-1:

HMS LINCS Batch ID: 10278-999-1
Provider: J Park (UCSF)
Provider Batch ID:
Salt: 999
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2012-11-14
Most Recent Update: 2016-12-02