Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
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Cetuximab | EGFR | ErbB | 100.0000 | 100.0000 | 100.0000 | 0.7284 | 0.8755 | 0.9754 | 0.5964 | 0.8555 | 0.9754 | 0.0000 | 0.0000 | 0.7916 | -0.0099 | 0.0234 | 0.0674 | 3.7461 | 100.0000 | 100.0000 | |
PS-1145 | IKK | NFKB | 100.0000 | 100.0000 | 100.0000 | 0.8452 | 0.9304 | 0.9718 | 0.8353 | 0.9304 | 0.9695 | 0.0000 | 0.0000 | 0.8067 | -0.0033 | 0.0200 | 0.0533 | 100.0000 | 100.0000 | 100.0000 | |
Nilotinib | ABL | nRTK | 100.0000 | 100.0000 | 100.0000 | 0.7849 | 0.9109 | 1.0055 | 0.7841 | 0.9109 | 1.0055 | 0.0000 | 0.0000 | 0.7234 | 0.0029 | 0.0487 | 0.0775 | 73.6076 | 100.0000 | 100.0000 | |
FTase Inhibitor I | Ftase | MAPK | 100.0000 | 100.0000 | 100.0000 | 0.7715 | 0.8851 | 0.9752 | 0.7468 | 0.8851 | 0.9752 | 0.0000 | 0.0000 | 0.0000 | 0.0099 | 0.0556 | 0.0941 | 100.0000 | 100.0000 | 100.0000 | |
Ribavirin | N/A | N/A | 100.0000 | 100.0000 | 100.0000 | 0.6045 | 0.7146 | 0.9546 | 0.4725 | 0.6701 | 0.9546 | 0.0000 | 0.0000 | 0.9838 | 0.0119 | 0.0416 | 0.0703 | 50.4745 | 100.0000 | 100.0000 | |
AG1024 | IGF1R | RTK | 14.2327 | 62.8199 | 100.0000 | 0.3069 | 0.5828 | 0.8614 | -0.0340 | 0.2904 | 0.6353 | 0.3280 | 1.4424 | 3.0172 | 0.0186 | 0.0785 | 0.1208 | 8.3409 | 30.1991 | 100.0000 | |
Dichloroacetate | PDK | PDK | 100.0000 | 100.0000 | 100.0000 | 0.8082 | 0.8801 | 0.9216 | 0.7946 | 0.8670 | 0.9296 | 0.0000 | 0.0000 | 0.2064 | 0.0234 | 0.0440 | 0.0744 | 58.3872 | 100.0000 | 100.0000 | |
Lapatinib | EGFR/HER2 | ErbB | 31.2806 | 100.0000 | 100.0000 | 0.4954 | 0.7950 | 0.9113 | 0.2428 | 0.7519 | 0.9066 | 0.0000 | 0.2457 | 1.3492 | 0.0247 | 0.0703 | 0.1302 | 1.5972 | 63.5403 | 100.0000 | |
SB-3CT | MMP2/9 | MMP | 69.9094 | 100.0000 | 100.0000 | 0.4441 | 0.6795 | 0.8316 | -0.1049 | 0.6210 | 0.7846 | 0.0670 | 0.6905 | 2.4960 | 0.0290 | 0.0754 | 0.1306 | 27.8608 | 93.1362 | 100.0000 | |
Methotrexate | DHFR | Metabolism | 0.1850 | 100.0000 | 100.0000 | 0.3067 | 0.6372 | 0.9078 | 0.3672 | 0.5884 | 0.9117 | 0.0000 | 2.3582 | 4.5415 | 0.0328 | 0.2767 | 0.4502 | 0.0331 | 0.1737 | 100.0000 | |
Purvalanol A | CDK1 | CDK | 25.2896 | 54.7310 | 100.0000 | 0.0757 | 0.5333 | 0.7416 | -0.0675 | 0.5068 | 0.7450 | 1.0817 | 2.5000 | 4.2404 | 0.0335 | 0.0774 | 0.1767 | 18.1854 | 35.4887 | 52.3768 | |
Erlotinib | EGFR | ErbB | 6.4716 | 35.2468 | 100.0000 | 0.0317 | 0.4006 | 0.6354 | -0.8374 | -0.1704 | 0.3788 | 0.3155 | 0.7139 | 1.8126 | 0.0351 | 0.1228 | 0.2396 | 13.2839 | 41.2968 | 100.0000 | |
PD184352 | MEK | MAPK | 31.0822 | 100.0000 | 100.0000 | 0.4258 | 0.7584 | 0.9084 | -0.2272 | 0.7139 | 0.9084 | 0.0000 | 0.0524 | 0.4766 | 0.0368 | 0.0888 | 0.1432 | 63.7076 | 100.0000 | 100.0000 | |
TCS PIM-1 1 | Pim kinase | PIM | 90.9415 | 100.0000 | 100.0000 | 0.4852 | 0.6734 | 0.7827 | 0.3505 | 0.5918 | 0.7255 | 0.0000 | 1.5057 | 4.5238 | 0.0404 | 0.0756 | 0.1063 | 26.3980 | 73.0639 | 100.0000 | |
PD 98059 | MEK | MAPK | 100.0000 | 100.0000 | 100.0000 | 0.5235 | 0.6650 | 0.8191 | -0.1517 | 0.5395 | 0.8149 | 0.0000 | 0.2473 | 0.7779 | 0.0463 | 0.0842 | 0.1501 | 32.4005 | 100.0000 | 100.0000 | |
FR180204 | ERK1/2 | MAPK | 56.2203 | 100.0000 | 100.0000 | 0.4862 | 0.6317 | 0.8238 | -0.1433 | 0.2500 | 0.7055 | 0.0180 | 0.6403 | 1.9539 | 0.0470 | 0.0722 | 0.1058 | 65.9938 | 100.0000 | 100.0000 | |
Selumetinib | MEK | MAPK | 3.4703 | 100.0000 | 100.0000 | 0.2888 | 0.6993 | 0.8618 | 0.1384 | 0.6524 | 0.8687 | 0.0000 | 0.4990 | 0.9393 | 0.0510 | 0.1233 | 0.3040 | 0.3246 | 2.6951 | 100.0000 | |
L-779450 | BRAF | MAPK | 12.8318 | 28.9246 | 48.0158 | -0.2622 | 0.2749 | 0.3891 | -1.0000 | -0.6190 | -0.1023 | 1.0435 | 1.8204 | 3.7221 | 0.0544 | 0.0922 | 0.1394 | 20.7244 | 44.1580 | 61.2878 | |
Baicalein | Lipoxygenase | Metabolism | 41.6425 | 70.6950 | 100.0000 | -0.0508 | 0.2583 | 0.5386 | -0.5772 | 0.0203 | 0.4255 | 1.6411 | 2.5826 | 3.9209 | 0.0595 | 0.1090 | 0.1450 | 32.6213 | 62.3319 | 100.0000 | |
Pemetrexed | TYMS/DHFR/GARFT | TYMS | 70.1583 | 100.0000 | 100.0000 | 0.5012 | 0.6411 | 0.8577 | 0.5144 | 0.6941 | 0.8649 | 0.0000 | 0.7943 | 1.8547 | 0.0614 | 0.1870 | 0.3357 | 0.9463 | 34.1832 | 100.0000 | |
Glycyl-H-1152 | ROCK2 | N/A | 7.8389 | 29.5632 | 100.0000 | 0.0725 | 0.4318 | 0.6407 | -0.4259 | 0.0666 | 0.6245 | 0.3449 | 0.9010 | 2.0476 | 0.0704 | 0.1476 | 0.1891 | 2.5420 | 16.8696 | 100.0000 | |
Trametinib | MEK | MAPK | 0.1119 | 60.3200 | 100.0000 | 0.2676 | 0.5669 | 0.7582 | 0.2515 | 0.4183 | 0.5896 | 0.4854 | 1.1532 | 1.7735 | 0.0718 | 0.1864 | 0.3779 | 0.0100 | 0.4479 | 33.6419 | |
Gefitinib | EGFR | ErbB | 6.6704 | 12.9191 | 28.3915 | -0.2671 | 0.0424 | 0.3018 | -0.8465 | -0.5620 | -0.2259 | 0.9170 | 1.3719 | 2.5436 | 0.0767 | 0.1382 | 0.2408 | 9.0805 | 26.2291 | 41.5832 | |
AS-252424 | PI3K | PI3K | 19.5544 | 36.2256 | 100.0000 | 0.2865 | 0.4240 | 0.5918 | -0.9991 | 0.2157 | 0.5619 | 0.3148 | 0.6846 | 2.7243 | 0.0770 | 0.1059 | 0.1601 | 6.6689 | 89.5846 | 100.0000 | |
Nutlin 3a | MDM2 | MDM2 | 15.2348 | 24.3890 | 41.8634 | -0.3252 | -0.0482 | 0.2155 | -1.0000 | -0.8163 | -0.2697 | 1.1456 | 1.7429 | 2.5635 | 0.0828 | 0.1397 | 0.2099 | 23.6810 | 39.7952 | 62.9892 |