Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Cetuximab
EGFR
ErbB
100.0000 100.0000 100.0000 0.7284 0.8755 0.9754 0.5964 0.8555 0.9754 0.0000 0.0000 0.7916 -0.0099 0.0234 0.0674 3.7461 100.0000 100.0000
PS-1145
IKK
NFKB
100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000
Nilotinib
ABL
nRTK
100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000
FTase Inhibitor I
Ftase
MAPK
100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Ribavirin
N/A
N/A
100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000
AG1024
IGF1R
RTK
14.2327 62.8199 100.0000 0.3069 0.5828 0.8614 -0.0340 0.2904 0.6353 0.3280 1.4424 3.0172 0.0186 0.0785 0.1208 8.3409 30.1991 100.0000
Dichloroacetate
PDK
PDK
100.0000 100.0000 100.0000 0.8082 0.8801 0.9216 0.7946 0.8670 0.9296 0.0000 0.0000 0.2064 0.0234 0.0440 0.0744 58.3872 100.0000 100.0000
Lapatinib
EGFR/HER2
ErbB
31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
SB-3CT
MMP2/9
MMP
69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000
Methotrexate
DHFR
Metabolism
0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
Purvalanol A
CDK1
CDK
25.2896 54.7310 100.0000 0.0757 0.5333 0.7416 -0.0675 0.5068 0.7450 1.0817 2.5000 4.2404 0.0335 0.0774 0.1767 18.1854 35.4887 52.3768
Erlotinib
EGFR
ErbB
6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
PD184352
MEK
MAPK
31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000
TCS PIM-1 1
Pim kinase
PIM
90.9415 100.0000 100.0000 0.4852 0.6734 0.7827 0.3505 0.5918 0.7255 0.0000 1.5057 4.5238 0.0404 0.0756 0.1063 26.3980 73.0639 100.0000
PD 98059
MEK
MAPK
100.0000 100.0000 100.0000 0.5235 0.6650 0.8191 -0.1517 0.5395 0.8149 0.0000 0.2473 0.7779 0.0463 0.0842 0.1501 32.4005 100.0000 100.0000
FR180204
ERK1/2
MAPK
56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
Selumetinib
MEK
MAPK
3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
L-779450
BRAF
MAPK
12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
Baicalein
Lipoxygenase
Metabolism
41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
Glycyl-H-1152
ROCK2
N/A
7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Trametinib
MEK
MAPK
0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
Gefitinib
EGFR
ErbB
6.6704 12.9191 28.3915 -0.2671 0.0424 0.3018 -0.8465 -0.5620 -0.2259 0.9170 1.3719 2.5436 0.0767 0.1382 0.2408 9.0805 26.2291 41.5832
AS-252424
PI3K
PI3K
19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
Nutlin 3a
MDM2
MDM2
15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
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