Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | TUBB | TUBB | 0.0022 | 0.0051 | 0.0098 | -0.3944 | -0.0464 | 0.1697 | -0.4257 | -0.0477 | 0.1373 | 1.4024 | 1.6746 | 2.3040 | 0.4979 | 0.6215 | 0.8198 | 0.0027 | 0.0049 | 0.0080 | |
| Torkinib | MTOR | MTOR | 0.0008 | 0.0021 | 0.0184 | -0.5713 | -0.3826 | -0.2014 | -0.6715 | -0.4047 | -0.1504 | 0.3324 | 0.3720 | 0.5454 | 0.6694 | 0.8411 | 1.0104 | 0.0046 | 0.0211 | 0.0646 | |
| Taxol | TUBB | TUBB | 0.0078 | 0.0104 | 0.0155 | -0.5505 | -0.2204 | 0.0319 | -0.5168 | -0.1393 | 0.1113 | 1.6357 | 2.0915 | 3.1238 | 0.5399 | 0.6855 | 0.9358 | 0.0096 | 0.0111 | 0.0153 | |
| Trametinib | MEK | MAPK | 0.1119 | 60.3200 | 100.0000 | 0.2676 | 0.5669 | 0.7582 | 0.2515 | 0.4183 | 0.5896 | 0.4854 | 1.1532 | 1.7735 | 0.0718 | 0.1864 | 0.3779 | 0.0100 | 0.4479 | 33.6419 | |
| Ixabepilone | TUBB | TUBB | 0.0045 | 0.0114 | 0.0487 | -0.9765 | -0.9460 | -0.8485 | -0.9892 | -0.7196 | -0.5742 | 0.3937 | 0.7623 | 1.6684 | 0.6842 | 0.8505 | 0.9658 | 0.0102 | 0.0892 | 0.7025 | |
| GSK461364 | PLK1 | PLK | 0.0087 | 0.0183 | 0.0805 | -0.6111 | -0.4222 | -0.2111 | -0.4745 | -0.3080 | -0.0919 | 2.4728 | 2.7172 | 4.9263 | 0.4701 | 0.6125 | 0.7345 | 0.0105 | 0.0265 | 0.3325 | |
| Geldanamycin | HSP90 | HSP90 | 0.0092 | 0.0240 | 0.0425 | -0.4324 | -0.2962 | -0.0904 | -0.3507 | -0.2347 | -0.0323 | 1.6732 | 2.3748 | 3.3908 | 0.6486 | 0.7709 | 0.9035 | 0.0116 | 0.0269 | 0.0560 | |
| Vinorelbine | TUBB | TUBB | 0.0079 | 0.0130 | 0.0470 | -0.9358 | -0.8653 | -0.6758 | -1.0000 | -0.5683 | -0.3360 | 0.3815 | 2.2644 | 3.6055 | 0.6197 | 0.8320 | 1.0409 | 0.0132 | 0.0302 | 0.9743 | |
| Gemcitabine | DNA replication | DNA replication | 0.0255 | 0.1767 | 1.3221 | -0.1534 | 0.1060 | 0.2747 | -0.1430 | 0.1441 | 0.3026 | 0.5558 | 1.2204 | 2.6334 | 0.3723 | 0.5392 | 0.7460 | 0.0153 | 0.0741 | 0.2614 | |
| Omipalisib | PI3K | PI3K | 0.0049 | 0.0154 | 0.0397 | -0.8281 | -0.5752 | -0.4164 | -0.8004 | -0.5070 | -0.2908 | 0.6200 | 0.7592 | 0.9464 | 0.6332 | 0.8101 | 0.9689 | 0.0158 | 0.0370 | 0.0945 | |
| Sirolimus | MTOR | MTOR | 0.0785 | 2.7199 | 100.0000 | -0.0907 | 0.1172 | 0.3521 | -0.3854 | 0.0690 | 0.4042 | 0.2746 | 0.5743 | 1.0909 | 0.2471 | 0.4095 | 0.5054 | 0.0261 | 0.5698 | 12.7823 | |
| Bortezomib | Proteasome | Proteasome | 0.0169 | 0.0283 | 0.0758 | -0.9074 | -0.8026 | -0.7299 | -0.9162 | -0.8011 | -0.7357 | 1.1703 | 1.8347 | 2.7508 | 0.9093 | 1.0406 | 1.1781 | 0.0266 | 0.0496 | 0.1485 | |
| Methotrexate | DHFR | Metabolism | 0.1850 | 100.0000 | 100.0000 | 0.3067 | 0.6372 | 0.9078 | 0.3672 | 0.5884 | 0.9117 | 0.0000 | 2.3582 | 4.5415 | 0.0328 | 0.2767 | 0.4502 | 0.0331 | 0.1737 | 100.0000 | |
| Ispinesib | KSP | Kinesin | 0.0263 | 0.0439 | 0.1261 | -0.9817 | -0.9567 | -0.8688 | -1.0000 | -0.9800 | -0.6258 | 0.4997 | 1.2912 | 3.1780 | 0.5293 | 0.6720 | 0.8104 | 0.0357 | 0.4315 | 1.3590 | |
| GSK923295 | CENPE | Kinesin | 0.0392 | 0.0651 | 0.2250 | -0.5702 | -0.2653 | -0.0001 | -0.5044 | -0.2084 | 0.0089 | 1.0722 | 2.1595 | 3.4297 | 0.3588 | 0.4764 | 0.6241 | 0.0452 | 0.0615 | 1.0057 | |
| 17-AAG | HSP90 | HSP90 | 0.0442 | 0.0876 | 0.1713 | -0.7309 | -0.6010 | -0.3062 | -0.5924 | -0.4000 | -0.2370 | 0.8987 | 1.8748 | 3.3051 | 0.4754 | 0.6987 | 0.8282 | 0.0680 | 0.1218 | 0.3890 | |
| Topotecan | TOP1 | TOP | 0.0324 | 0.1223 | 0.4672 | -0.7615 | -0.5906 | -0.2740 | -0.8265 | -0.6901 | -0.4582 | 0.5573 | 0.7931 | 1.1373 | 0.5801 | 0.7088 | 0.8375 | 0.0774 | 0.7078 | 1.2170 | |
| Dactolisib | PI3K | PI3K | 0.1885 | 0.5181 | 100.0000 | 0.2549 | 0.5042 | 0.6208 | 0.2262 | 0.4314 | 0.5885 | 0.0000 | 2.2633 | 4.9147 | 0.2133 | 0.2744 | 0.3494 | 0.1148 | 0.3521 | 100.0000 | |
| LBH589 | HDAC | HDAC | 0.0792 | 0.1432 | 0.2719 | -0.9159 | -0.8072 | -0.7128 | -0.9155 | -0.7955 | -0.6832 | 1.1720 | 1.5004 | 2.1649 | 0.5471 | 0.6739 | 0.7846 | 0.1472 | 0.2600 | 0.4626 | |
| MG-132 | Proteasome | Proteasome | 0.1071 | 0.1768 | 0.5078 | -0.8632 | -0.7505 | -0.5413 | -0.8499 | -0.6667 | -0.5123 | 1.5044 | 2.4128 | 3.5768 | 0.6530 | 0.7329 | 0.8677 | 0.1559 | 0.2469 | 1.0059 | |
| Disulfiram | Proteasome | Proteasome | 0.2148 | 13.4616 | 100.0000 | -0.6139 | 0.0054 | 0.4486 | -0.9836 | -0.0088 | 0.5061 | 0.2242 | 2.0208 | 4.9998 | 0.1469 | 0.2459 | 0.3654 | 0.1623 | 16.2617 | 100.0000 | |
| Pevonedistat | NAE1 | NAE1 | 0.1439 | 0.3445 | 1.2615 | -0.3074 | -0.0880 | 0.0407 | -0.4612 | -0.1540 | 0.0480 | 0.6476 | 0.9529 | 1.4328 | 0.3433 | 0.4344 | 0.5442 | 0.1672 | 0.7014 | 1.4696 | |
| Doxorubicin | TOP2 | TOP | 0.1488 | 0.2099 | 0.7023 | -0.9456 | -0.8552 | -0.5483 | -0.8723 | -0.7083 | -0.3772 | 1.0561 | 1.4782 | 2.5260 | 0.5209 | 0.6697 | 0.8073 | 0.2444 | 0.4713 | 1.2126 | |
| Triciribine | AKT | AKT | 0.1497 | 1.0069 | 10.2321 | -0.2208 | 0.0730 | 0.3595 | -0.6783 | -0.3270 | 0.0049 | 0.3693 | 0.5173 | 0.9769 | 0.1961 | 0.3180 | 0.4712 | 0.2958 | 1.3169 | 18.2553 | |
| Mebendazole | N/A | N/A | 0.2591 | 0.5241 | 2.5192 | -0.2079 | 0.0053 | 0.2103 | -0.2699 | -0.1133 | 0.2272 | 0.7947 | 1.2360 | 1.9961 | 0.2868 | 0.3432 | 0.4692 | 0.3151 | 0.3915 | 2.6571 |