Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Lapatinib
EGFR/HER2
ErbB
31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
Dichloroacetate
PDK
PDK
100.0000 100.0000 100.0000 0.8082 0.8801 0.9216 0.7946 0.8670 0.9296 0.0000 0.0000 0.2064 0.0234 0.0440 0.0744 58.3872 100.0000 100.0000
Cetuximab
EGFR
ErbB
100.0000 100.0000 100.0000 0.7284 0.8755 0.9754 0.5964 0.8555 0.9754 0.0000 0.0000 0.7916 -0.0099 0.0234 0.0674 3.7461 100.0000 100.0000
Methotrexate
DHFR
Metabolism
0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
FTase Inhibitor I
Ftase
MAPK
100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Selumetinib
MEK
MAPK
3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
Ribavirin
N/A
N/A
100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000
PD184352
MEK
MAPK
31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
PS-1145
IKK
NFKB
100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000
PD 98059
MEK
MAPK
100.0000 100.0000 100.0000 0.5235 0.6650 0.8191 -0.1517 0.5395 0.8149 0.0000 0.2473 0.7779 0.0463 0.0842 0.1501 32.4005 100.0000 100.0000
TCS PIM-1 1
Pim kinase
PIM
90.9415 100.0000 100.0000 0.4852 0.6734 0.7827 0.3505 0.5918 0.7255 0.0000 1.5057 4.5238 0.0404 0.0756 0.1063 26.3980 73.0639 100.0000
Dactolisib
PI3K
PI3K
0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
Nilotinib
ABL
nRTK
100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000
JNK-IN-5A
JNK
JNK
1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
FR180204
ERK1/2
MAPK
56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
SB-3CT
MMP2/9
MMP
69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000
ICRF-193
TOP2
TOP
8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
Disulfiram
Proteasome
Proteasome
0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
Temsirolimus
MTOR
MTOR
0.1192 1.7003 10.0307 -0.9332 -0.8176 -0.6679 -1.0000 -1.0000 -0.9967 0.2520 0.4363 1.0813 0.3951 0.4933 0.6311 6.4751 18.8586 43.0334
Sirolimus
MTOR
MTOR
0.0785 2.7199 100.0000 -0.0907 0.1172 0.3521 -0.3854 0.0690 0.4042 0.2746 0.5743 1.0909 0.2471 0.4095 0.5054 0.0261 0.5698 12.7823
Everolimus
MTOR
MTOR
0.0432 0.6717 4.3873 -0.8294 -0.6714 -0.2303 -1.0000 -1.0000 -0.6838 0.2890 0.4230 0.7677 0.3295 0.4415 0.5925 1.5205 9.7227 26.2255
AS-252424
PI3K
PI3K
19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
Erlotinib
EGFR
ErbB
6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
AG1024
IGF1R
RTK
14.2327 62.8199 100.0000 0.3069 0.5828 0.8614 -0.0340 0.2904 0.6353 0.3280 1.4424 3.0172 0.0186 0.0785 0.1208 8.3409 30.1991 100.0000
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