Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7542.074 | uM | 0.06072 | 0.08408 | -0.9251 | -0.9354 | 3.2395 | 1.1458 | 0.9975 | 1.4673 | |
| SK-BR-3 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7912.068 | uM | 0.00112 | 0.00189 | -0.4187 | -0.3319 | 0.9812 | 1.1470 | 0.9516 | 0.5196 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7816.042 | uM | 0.00742 | 0.00981 | -0.9736 | -0.7383 | 3.2478 | 1.1471 | 0.9833 | 0.9332 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 9244.001 | uM | 0.01952 | 0.02432 | -0.9955 | -0.9995 | 5.0000 | 1.1472 | 0.9893 | 0.5421 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9777.049 | uM | 0.01710 | 0.02148 | -0.7904 | -0.5779 | 3.3677 | 1.1473 | 0.7012 | 0.6254 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7793.011 | uM | 0.01320 | 0.01840 | -0.7052 | -0.6394 | 2.4793 | 1.1485 | 0.9950 | 1.1456 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7884.05 | uM | 0.02659 | 0.03251 | -0.9340 | -0.8649 | 5.0000 | 1.1490 | 0.9980 | 0.3869 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9186.119 | uM | inf | inf | -0.3982 | -0.3982 | 0.0000 | 1.1503 | 0.2795 | 0.4743 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 15335.203 | uM | 0.01161 | 0.03143 | -0.9577 | -0.9350 | 1.0585 | 1.1505 | 0.9995 | 0.8170 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 15335.203 | uM | 0.01161 | 0.03143 | -0.9577 | -0.9350 | 1.0585 | 1.1505 | 0.9995 | 0.8170 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7844.037 | uM | 0.02203 | 0.03608 | -0.9196 | -0.8023 | 1.9395 | 1.1506 | 0.9601 | 0.3471 | |
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7912.018 | uM | 0.01004 | 0.01213 | -0.9507 | -0.7888 | 5.0000 | 1.1511 | 0.9894 | 0.7203 | |
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7455.095 | uM | 0.00203 | 0.00339 | -0.9014 | -0.6099 | 1.5659 | 1.1517 | 0.9624 | 1.8461 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9244.001 | uM | 0.00874 | 0.01067 | -0.8996 | -0.8591 | 5.0000 | 1.1518 | 0.9961 | 0.5421 | |
| EFM-192B | HER2amp | Luminal | Torkinib | 15288.211 | uM | 0.00137 | 0.00325 | -0.6816 | -0.5670 | 0.8789 | 1.1523 | 0.9810 | 0.9250 | |||
| CAMA-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5911.074 | uM | 0.04547 | 0.09258 | -0.9460 | -0.9060 | 1.4540 | 1.1535 | 0.9813 | 1.1317 | |
| CAMA-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5911.074 | uM | 0.04547 | 0.09258 | -0.9460 | -0.9060 | 1.4540 | 1.1535 | 0.9813 | 1.1317 | |
| MDA-MB-157 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10093.034 | uM | 0.00588 | 0.06554 | -0.9994 | -1.0000 | 0.4558 | 1.1551 | 0.8879 | 0.9732 | |
| SUM149PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9830.012 | uM | 0.00575 | 0.00857 | -0.6166 | -0.6015 | 1.9785 | 1.1551 | 0.9977 | 1.8343 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7444.065 | uM | 1.45170 | 2.67320 | -0.9873 | -0.9919 | 1.7904 | 1.1581 | 0.9992 | 0.7419 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7811.001 | uM | 0.02213 | 0.02753 | -0.9922 | -0.9899 | 5.0000 | 1.1592 | 0.9888 | 0.4464 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7432.084 | uM | 0.01028 | 0.01685 | -0.9998 | -0.9951 | 2.2156 | 1.1594 | 0.9992 | 0.8538 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7905.012 | uM | 0.01689 | 0.02851 | -0.7388 | -0.7974 | 1.8227 | 1.1600 | 0.9843 | 0.7027 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7477.084 | uM | 0.00794 | 0.01777 | -0.9982 | -1.0000 | 1.3641 | 1.1602 | 0.9984 | 0.9476 |