Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9536.006 | 0.0144 | -0.9317 | 1.2564 | |
| HCC1143 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 92.7 | uM | 7810.006 | 0.5600 | 0.1021 | 0.9730 | |
| SUM52PE | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9878.006 | 0.0242 | -0.8608 | 1.3968 | |
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9759.006 | 0.0609 | -0.7787 | 1.2714 | |
| 600MPE | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9118.006 | 0.0070 | -0.9773 | 1.1089 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9797.006 | 0.0023 | -1.0000 | 0.4196 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9708.006 | 0.0004 | -1.0000 | 0.6313 | |
| SUM149PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 92.7 | uM | 9830.006 | 0.0060 | -0.8987 | 1.7160 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7818.018 | 0.5805 | 0.1564 | 0.9928 | |
| HCC1187 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7811.018 | 0.2759 | -0.8713 | 0.4694 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7813.018 | 0.0020 | -0.9987 | 0.8420 | |
| HCC1187 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7812.042 | 0.2610 | -0.4977 | 0.9722 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7814.042 | 0.1310 | -0.8215 | 0.8414 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7816.042 | 0.1588 | -0.7217 | 0.9332 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7820.042 | 0.5850 | -0.2846 | 0.5216 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7807.042 | 0.1305 | -0.2683 | 2.0250 | |
| BT-483 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7801.018 | 0.5414 | -0.2915 | 0.5913 | |
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7804.042 | 0.0707 | -0.3084 | 2.4955 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7808.052 | 0.0504 | -0.3990 | 2.4842 | |
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7803.042 | 0.1324 | -0.0219 | 2.8270 | |
| BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9.27 | uM | 9024.018 | 0.0523 | -0.2948 | 2.8306 | |
| CAMA-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7805.018 | 0.3275 | -0.2455 | 1.1451 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7794.018 | 0.1761 | -0.2882 | 1.6812 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 7793.018 | 0.1156 | -0.6105 | 1.3186 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9.27 | uM | 9035.018 | 0.1244 | -0.2396 | 2.1555 |