Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13125.177 | 0.0001 | -1.0000 | 0.8991 | |
| HMT-3522 S1 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 172 | uM | 7911.017 | 0.0001 | -0.9915 | 1.6151 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13070.177 | 0.0001 | -0.9999 | 0.9040 | |
| HCC1187 | TNBC | Basal A | Methylglyoxal | 54000 | uM | 13726.184 | 0.0002 | -1.0000 | 0.3574 | |||
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7896.017 | 0.0002 | -0.9995 | 1.0113 | |
| SUM52PE | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 9878.017 | 0.0002 | -0.9967 | 1.3463 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7862.017 | 0.0002 | -0.9973 | 1.3198 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7824.017 | 0.0002 | -0.9871 | 1.6694 | |
| HCC1937 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7832.017 | 0.0002 | -0.9960 | 1.3404 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13038.177 | 0.0002 | -0.9998 | 0.9161 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7864.017 | 0.0002 | -0.9870 | 1.6561 | |
| MDA-MB-175-VII | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7885.017 | 0.0002 | -1.0000 | 0.5647 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12667.177 | 0.0002 | -1.0000 | 0.5892 | |
| T47DKBLUC | Unknown | Unknown | Chloroquine | 66.5 | uM | 13070.177 | 0.0002 | -0.9998 | 0.9040 | |||
| 184A1 | NM | Basal | Epirubicin | TOP2 | TOP | 172 | uM | 9047.017 | 0.0002 | -0.9999 | 0.8440 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7803.017 | 0.0002 | -0.8801 | 2.9572 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 5901.074 | 0.0002 | -0.9772 | 1.8718 | |
| HCC1187 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7812.017 | 0.0002 | -0.9987 | 1.1362 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 5901.074 | 0.0002 | -0.9772 | 1.8718 | |
| HCC1143 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7810.017 | 0.0002 | -0.9998 | 0.8986 | |
| HCC1806 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7830.017 | 0.0002 | -0.9837 | 1.7247 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 92 | uM | 9039.078 | 0.0002 | -1.0000 | 0.6306 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7863.017 | 0.0002 | -0.9777 | 1.9568 | |
| SUM52PE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7541.067 | 0.0002 | -0.9936 | 1.4459 | |
| MCF 10F | NM | - | Methylglyoxal | 54000 | uM | 13672.184 | 0.0002 | -0.9500 | 2.3721 |