Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10816.15 | 1.0398 | 1.2751 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10816.15 | 1.1850 | 2.5010 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10816.15 | 1.2755 | 3.4632 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10816.15 | 1.1116 | 1.8355 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10816.15 | 1.2988 | 3.7375 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10816.15 | 1.2570 | 3.2528 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10816.15 | 1.2047 | 2.6969 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10816.15 | 1.4082 | 5.1867 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10816.15 | 1.2179 | 2.8323 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10816.15 | 1.1589 | 2.2536 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10816.15 | 0.6632 | -0.4840 | 0.3031 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10816.15 | 0.3061 | -0.9598 | 0.3031 | ||
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10816.15 | 1.4618 | 5.9987 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10816.15 | 1.2191 | 2.8446 | 0.3031 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10816.15 | 1.2333 | 2.9943 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10816.15 | 0.8720 | 0.2730 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10816.15 | 1.4683 | 6.1020 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10816.15 | 1.2067 | 2.7169 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10816.15 | 1.3861 | 4.8724 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10816.15 | 1.0722 | 1.5169 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10816.15 | 1.4003 | 5.0731 | 0.3031 | ||
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10816.15 | 1.2428 | 3.0963 | 0.3031 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10816.15 | 0.5234 | -0.7637 | 0.3031 | ||
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10816.15 | 1.0809 | 1.5848 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10816.15 | 1.3786 | 4.7683 | 0.3031 |