Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | 0.0000 | uM | 48 | hr | 209 | 9 | 0.4038 | 0.0431 | 4 | |||
| WM-115 | 0.0000 | uM | 48 | hr | 224 | 22 | 0.4078 | 0.0982 | 4 | |||
| WM-115 | 0.0000 | uM | 48 | hr | 226 | 15 | 0.4260 | 0.0664 | 4 | |||
| SB590885 | WM-115 | 3.1600 | uM | 48 | hr | 266 | 42 | 0.4522 | 0.6829 | 0.1579 | 0.1306 | 3 |
| WM-115 | 0.0000 | uM | 48 | hr | 271 | 17 | 0.5128 | 0.0627 | 3 | |||
| WM-115 | 0.0000 | uM | 48 | hr | 276 | 17 | 0.5229 | 0.0616 | 4 | |||
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 277 | 111 | 0.3351 | 0.4240 | 0.4007 | 0.3788 | 3 |
| Vemurafenib | WM-115 | 0.0032 | uM | 48 | hr | 279 | 20 | 0.5229 | 1.0448 | 0.0717 | 0.0621 | 4 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 304 | 17 | 0.5794 | 1.0175 | 0.0559 | 0.0459 | 4 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 307 | 17 | 0.5855 | 1.0175 | 0.0554 | 0.0459 | 3 |
| WM-115 | 0.0000 | uM | 48 | hr | 311 | 11 | 0.6057 | 0.0354 | 4 | |||
| PLX-4720 | WM-115 | 1.0000 | uM | 24 | hr | 315 | 20 | 0.5634 | 1.0218 | 0.0635 | 0.0643 | 2 |
| SB590885 | WM-115 | 3.1600 | uM | 48 | hr | 322 | 39 | 0.5713 | 0.6829 | 0.1211 | 0.1306 | 4 |
| Vemurafenib | WM-115 | 3.1600 | uM | 48 | hr | 322 | 46 | 0.5572 | 0.8843 | 0.1429 | 0.1161 | 4 |
| Selumetinib | WM-115 | 3.1600 | uM | 48 | hr | 325 | 98 | 0.4583 | 0.5920 | 0.3015 | 0.2687 | 4 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 332 | 141 | 0.3856 | 0.4240 | 0.4247 | 0.3788 | 4 |
| Selumetinib | WM-115 | 3.1600 | uM | 24 | hr | 347 | 46 | 0.5749 | 0.7277 | 0.1326 | 0.1433 | 2 |
| PLX-4720 | WM-115 | 0.0032 | uM | 48 | hr | 355 | 18 | 0.6804 | 1.2547 | 0.0507 | 0.0421 | 3 |
| AZ-628 | WM-115 | 0.0032 | uM | 48 | hr | 356 | 9 | 0.7006 | 1.0559 | 0.0253 | 0.0302 | 3 |
| WM-115 | 0.0000 | uM | 48 | hr | 360 | 12 | 0.7026 | 0.0333 | 4 | |||
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 365 | 133 | 0.4684 | 0.4240 | 0.3644 | 0.3788 | 2 |
| Vemurafenib | WM-115 | 3.1600 | uM | 48 | hr | 369 | 55 | 0.6339 | 0.8843 | 0.1491 | 0.1161 | 3 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 372 | 121 | 0.5067 | 0.4240 | 0.3253 | 0.3788 | 1 |
| Vemurafenib | WM-115 | 0.0100 | uM | 48 | hr | 373 | 25 | 0.7026 | 1.2411 | 0.0670 | 0.0504 | 3 |
| WM-115 | 0.0000 | uM | 48 | hr | 373 | 18 | 0.7167 | 0.0483 | 2 |