Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLX-4720 | K2 | 0.0100 | uM | 48 | hr | 3571 | 0 | 1.3032 | 1.2705 | 0.0000 | 0.0022 | 2 |
| PLX-4720 | K2 | 0.0032 | uM | 48 | hr | 3865 | 1 | 1.4101 | 1.3444 | 0.0003 | 0.0024 | 1 |
| Selumetinib | K2 | 0.0100 | uM | 24 | hr | 1521 | 1 | 0.8940 | 1.1449 | 0.0007 | 0.0032 | 3 |
| K2 | 0.0000 | uM | 24 | hr | 743 | 1 | 0.4364 | 0.0013 | 4 | |||
| AZ-628 | MZ7-mel | 0.1000 | uM | 24 | hr | 1651 | 3 | 1.2485 | 1.1884 | 0.0018 | 0.0081 | 1 |
| PLX-4720 | MZ7-mel | 1.0000 | uM | 24 | hr | 963 | 3 | 0.7273 | 0.9557 | 0.0031 | 0.0127 | 3 |
| PLX-4720 | K2 | 0.1000 | uM | 24 | hr | 1202 | 3 | 0.7052 | 1.4881 | 0.0025 | 0.0032 | 4 |
| Selumetinib | K2 | 0.0316 | uM | 24 | hr | 1941 | 3 | 1.1398 | 1.0203 | 0.0015 | 0.0045 | 1 |
| AZ-628 | K2 | 0.0316 | uM | 24 | hr | 3254 | 3 | 1.9120 | 1.5718 | 0.0009 | 0.0028 | 1 |
| AZ-628 | K2 | 0.0316 | uM | 24 | hr | 1886 | 3 | 1.1074 | 1.5718 | 0.0016 | 0.0028 | 3 |
| SB590885 | K2 | 0.0316 | uM | 24 | hr | 2387 | 4 | 1.4015 | 1.8176 | 0.0017 | 0.0022 | 3 |
| K2 | 0.0000 | uM | 48 | hr | 3568 | 4 | 1.3007 | 0.0011 | 1 | |||
| K2 | 0.0000 | uM | 24 | hr | 768 | 4 | 0.4493 | 0.0052 | 3 | |||
| K2 | 0.0000 | uM | 48 | hr | 3670 | 4 | 1.3379 | 0.0011 | 1 | |||
| Vemurafenib | K2 | 0.1000 | uM | 24 | hr | 2673 | 4 | 1.5697 | 2.1002 | 0.0015 | 0.0017 | 4 |
| AZ-628 | K2 | 0.0100 | uM | 48 | hr | 2849 | 4 | 1.0383 | 1.0336 | 0.0014 | 0.0030 | 1 |
| PLX-4720 | MZ7-mel | 0.1000 | uM | 24 | hr | 1607 | 4 | 1.2144 | 1.1936 | 0.0025 | 0.0050 | 2 |
| K2 | 0.0000 | uM | 24 | hr | 1162 | 4 | 0.6811 | 0.0034 | 1 | |||
| PLX-4720 | K2 | 0.0316 | uM | 48 | hr | 3255 | 5 | 1.1861 | 1.1865 | 0.0015 | 0.0020 | 3 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 24 | hr | 1662 | 5 | 1.2553 | 1.1367 | 0.0030 | 0.0100 | 2 |
| Selumetinib | K2 | 0.0032 | uM | 48 | hr | 3377 | 5 | 1.2306 | 1.1652 | 0.0015 | 0.0027 | 2 |
| SB590885 | K2 | 0.0316 | uM | 48 | hr | 4144 | 5 | 1.5105 | 1.3782 | 0.0012 | 0.0017 | 1 |
| SB590885 | K2 | 0.0032 | uM | 48 | hr | 4079 | 5 | 1.4868 | 1.5110 | 0.0012 | 0.0019 | 2 |
| AZ-628 | K2 | 0.0032 | uM | 48 | hr | 3396 | 5 | 1.2375 | 1.1976 | 0.0015 | 0.0026 | 2 |
| AZ-628 | MZ7-mel | 0.0316 | uM | 24 | hr | 1623 | 5 | 1.2258 | 1.0498 | 0.0031 | 0.0104 | 2 |