Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | ZSTK474 | 3 | sigmoid | sigmoid | Hs578T ZSTK474 3 | 8 | 2.863 | 0.913 | 0.31 | 0.201 | 0.613 | 0.143 | 0.846 | 0.999 | 6.21e-10 | NA | 0.607 | 0.298 | 0.767 | 0.329 | 0.211 | 0.895 | 0.999 | 1.43e-09 | NA | |
Hs 578T | ZSTK474 | 2 | sigmoid | sigmoid | Hs578T ZSTK474 2 | 8 | 2.554 | 0.715 | 0.187 | 0.263 | 5.92 | -0.896 | 0.485 | 0.995 | 1.27e-07 | NA | 0.583 | 0.264 | 0.722 | 0.583 | 0.0 | 0.56 | 0.993 | 3.28e-07 | NA | |
Hs 578T | ZSTK474 | 1 | sigmoid | sigmoid | Hs578T ZSTK474 1 | 8 | 1.968 | 0.325 | 0.137 | 0.279 | 0.265 | 0.0807 | 0.854 | 0.973 | 1.94e-05 | NA | 0.471 | 0.329 | 0.764 | 0.149 | 0.343 | 1.01 | 0.972 | 2.27e-05 | NA | |
Hs 578T | WYE-125132 | 3 | sigmoid | sigmoid | Hs578T WYE-132 3 | 8 | 2.876 | 0.0568 | 0.189 | 0.452 | 0.0346 | 0.192 | 0.975 | 0.996 | 7.69e-08 | NA | 0.0403 | 0.224 | 0.522 | 0.0221 | 0.221 | 0.97 | 0.993 | 4.12e-07 | NA | |
Hs 578T | WYE-125132 | 2 | sigmoid | sigmoid | Hs578T WYE-132 2 | 8 | 2.544 | 0.0374 | 0.152 | 0.505 | 0.0268 | 0.147 | 1.04 | 0.999 | 8.81e-10 | NA | 0.0344 | 0.246 | 0.516 | 0.0183 | 0.239 | 1.03 | 0.999 | 2.53e-09 | NA | |
Hs 578T | WYE-125132 | 1 | sigmoid | sigmoid | Hs578T WYE-132 1 | 8 | 2.015 | 0.0322 | 0.0601 | 0.551 | 0.0286 | 0.0544 | 0.962 | 0.998 | 4.17e-09 | NA | 0.0469 | 0.278 | 0.55 | 0.0207 | 0.275 | 0.978 | 0.999 | 2.33e-09 | NA | |
Hs 578T | Trametinib | 3 | sigmoid | sigmoid | Hs578T trametinib 3 | 8 | 2.830 | 0.0128 | 0.0657 | 0.644 | 0.0112 | 0.0447 | 0.702 | 0.998 | 4.02e-09 | NA | 0.00864 | 0.168 | 0.366 | 0.00512 | 0.157 | 0.722 | 0.998 | 5.57e-09 | NA | |
Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
Hs 578T | Trametinib | 1 | sigmoid | sigmoid | Hs578T trametinib 1 | 8 | 2.044 | 0.00353 | -0.00904 | 0.765 | 0.00516 | -0.0906 | 0.437 | 0.992 | 4.85e-07 | NA | 0.00661 | 0.238 | 0.385 | 0.00213 | 0.201 | 0.456 | 0.993 | 3e-07 | NA | |
Hs 578T | Torin2 | 3 | sigmoid | sigmoid | Hs578T Torin2 3 | 8 | 2.844 | 0.0272 | -0.327 | 0.667 | 0.144 | -0.614 | 0.48 | 0.994 | 2.62e-07 | NA | 0.0164 | 0.0451 | 0.381 | 0.0148 | 0.0308 | 0.638 | 0.995 | 1.07e-07 | NA | |
Hs 578T | Torin2 | 2 | sigmoid | sigmoid | Hs578T Torin2 2 | 8 | 2.528 | 0.0153 | -0.467 | 0.778 | 0.112 | -0.771 | 0.47 | 0.986 | 2.55e-06 | NA | 0.0122 | 0.0353 | 0.352 | 0.0109 | 0.036 | 0.668 | 0.984 | 4.09e-06 | NA | |
Hs 578T | Torin2 | 1 | sigmoid | sigmoid | Hs578T Torin2 1 | 8 | 2.031 | 0.015 | -0.405 | 0.761 | 0.0631 | -0.56 | 0.522 | 0.992 | 5.31e-07 | NA | 0.021 | 0.0851 | 0.419 | 0.0163 | 0.0756 | 0.64 | 0.993 | 3.63e-07 | NA | |
Hs 578T | Torin1 | 3 | sigmoid | sigmoid | Hs578T Torin1 3 | 8 | 2.860 | 0.0307 | 0.174 | 0.514 | 0.0196 | 0.176 | 0.964 | 0.999 | 2.01e-09 | NA | 0.0212 | 0.218 | 0.469 | 0.0119 | 0.222 | 1.02 | 0.998 | 1.17e-08 | NA | |
Hs 578T | Torin1 | 2 | sigmoid | sigmoid | Hs578T Torin1 2 | 8 | 2.548 | 0.0205 | 0.144 | 0.566 | 0.0148 | 0.14 | 1.0 | 0.999 | 3.13e-10 | NA | 0.0182 | 0.241 | 0.463 | 0.00975 | 0.24 | 1.04 | 0.999 | 6.11e-10 | NA | |
Hs 578T | Torin1 | 1 | sigmoid | sigmoid | Hs578T Torin1 1 | 8 | 1.956 | 0.0217 | 0.0183 | 0.598 | 0.0203 | 0.0286 | 0.911 | 0.994 | 1.81e-07 | NA | 0.0321 | 0.267 | 0.524 | 0.0141 | 0.28 | 0.995 | 0.996 | 8.78e-08 | NA | |
Hs 578T | TGX221 | 3 | sigmoid | sigmoid | Hs578T TGX-221 3 | 8 | 2.818 | 24.2 | 0.885 | 0.0148 | 88.9 | -1.0 | 0.843 | 0.958 | 7.66e-05 | NA | 23.4 | 0.846 | 0.98 | 23.4 | 0.0 | 0.862 | 0.953 | 0.000103 | NA | |
Hs 578T | TGX221 | 2 | sigmoid | sigmoid | Hs578T TGX-221 2 | 8 | 2.462 | Inf | 0.816 | 0.0307 | 0.904 | 0.781 | 1.29 | 0.964 | 4.56e-05 | NA | Inf | 0.789 | 0.964 | 0.834 | 0.754 | 1.3 | 0.96 | 6.63e-05 | NA | |
Hs 578T | TGX221 | 1 | sigmoid | sigmoid | Hs578T TGX-221 1 | 8 | 2.019 | 14.6 | 0.686 | 0.0936 | 23.9 | -0.133 | 0.479 | 0.995 | 1.07e-07 | NA | 27.2 | 0.708 | 0.91 | 11.5 | 0.171 | 0.484 | 0.995 | 1.48e-07 | NA | |
Hs 578T | Sirolimus | 3 | flat | flat | Hs578T rapamycin 3 | 8 | 2.836 | Inf | 0.675 | 0.309 | 0.0 | 0.675 | 0.01 | -1.79 | 1.0 | 0.691 | Inf | 0.604 | 0.621 | 0.0 | 0.604 | 0.01 | -3.02 | 1.0 | 0.621 | |
Hs 578T | Sirolimus | 2 | flat | flat | Hs578T rapamycin 2 | 8 | 2.536 | Inf | 0.623 | 0.341 | 0.0 | 0.623 | 0.01 | 0.16 | 0.593 | 0.66 | Inf | 0.589 | 0.623 | 0.0 | 0.589 | 0.01 | -0.232 | 1.0 | 0.624 | |
Hs 578T | Sirolimus | 1 | sigmoid | sigmoid | Hs578T rapamycin 1 | 8 | 2.013 | 110643.0 | 0.587 | 0.358 | 0.000237 | 0.432 | 0.1 | 0.879 | 0.00178 | NA | 9.61e+11 | 0.628 | 0.672 | 0.000175 | 0.487 | 0.1 | 0.851 | 0.00332 | NA | |
Hs 578T | XL147 | 3 | flat | flat | Hs578T pilaralisib 3 | 8 | 2.879 | Inf | 0.971 | -0.00618 | 0.0 | 0.971 | 0.01 | 0.331 | 0.299 | 1.0 | Inf | 0.959 | 1.01 | 0.0 | 0.959 | 0.01 | 0.319 | 0.315 | 1.0 | |
Hs 578T | XL147 | 2 | flat | flat | Hs578T pilaralisib 2 | 8 | 2.509 | Inf | 0.976 | 0.000255 | 0.0 | 0.976 | 0.01 | 0.435 | 0.181 | 0.997 | Inf | 0.97 | 1.0 | 0.0 | 0.97 | 0.01 | 0.432 | 0.183 | 0.996 | |
Hs 578T | XL147 | 1 | flat | flat | Hs578T pilaralisib 1 | 8 | 2.013 | Inf | 0.967 | 0.00411 | 0.0 | 0.967 | 0.01 | 0.193 | 0.525 | 0.991 | Inf | 0.967 | 0.996 | 0.0 | 0.967 | 0.01 | 0.196 | 0.519 | 0.991 | |
Hs 578T | PIK-93 | 3 | sigmoid | sigmoid | Hs578T PIK-93 3 | 8 | 2.816 | 2.36 | 0.412 | 0.0884 | 2.23 | 0.033 | 1.2 | 0.994 | 1.87e-07 | NA | 1.89 | 0.375 | 0.897 | 1.42 | 0.149 | 1.24 | 0.991 | 8.33e-07 | NA |