Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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  • 1 to 25 of 432 records
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 Sirolimus 3 72
flat
flat
BT20 rapamycin 0 3 72
8 2.661
Inf
0.54
0.46
0.0
0.54
0.01
NA
NA
0.54
Inf
0.499
0.499
0.0
0.499
0.01
NA
NA
0.499
BT-20 Sirolimus 2 72
flat
flat
BT20 rapamycin 0 2 72
8 1.952
Inf
0.421
0.579
0.0
0.421
0.01
NA
NA
0.421
Inf
0.513
0.513
0.0
0.513
0.01
NA
NA
0.513
BT-20 Everolimus 3 72
flat
flat
BT20 everolimus 0 3 72
8 2.422
Inf
0.475
0.456
0.0
0.475
0.01
0.602
0.0632
0.543
Inf
0.478
0.534
0.0
0.478
0.01
0.561
0.0844
0.534
BT-20 Everolimus 2 72
flat
flat
BT20 everolimus 0 2 72
8 1.785
Inf
0.426
0.574
0.0
0.426
0.01
NA
NA
0.426
Inf
0.547
0.547
0.0
0.547
0.01
NA
NA
0.547
BT-20 Sirolimus 1 72
flat
flat
BT20 rapamycin 0 1 72
8 2.100
Inf
0.568
0.431
0.0
0.568
0.01
-9.89
1.0
0.568
Inf
0.6
0.601
0.0
0.6
0.01
-13.0
1.0
0.6
Hs 578T Sirolimus 3
flat
flat
Hs578T rapamycin 3
8 2.836
Inf
0.675
0.309
0.0
0.675
0.01
-1.79
1.0
0.691
Inf
0.604
0.621
0.0
0.604
0.01
-3.02
1.0
0.621
Hs 578T Sirolimus 2
flat
flat
Hs578T rapamycin 2
8 2.536
Inf
0.623
0.341
0.0
0.623
0.01
0.16
0.593
0.66
Inf
0.589
0.623
0.0
0.589
0.01
-0.232
1.0
0.624
BT-549 Sirolimus 3 72
flat
flat
BT549 rapamycin 0 3 72
8 1.703
Inf
0.455
0.482
0.0
0.455
0.01
0.376
0.243
0.518
Inf
0.582
0.626
0.0
0.582
0.01
0.436
0.179
0.625
Hs 578T Everolimus 3
flat
flat
Hs578T everolimus 3
8 2.848
Inf
0.664
0.299
0.0
0.664
0.01
0.475
0.144
0.702
Inf
0.592
0.631
0.0
0.592
0.01
0.486
0.136
0.632
BT-20 Everolimus 1 72
flat
flat
BT20 everolimus 0 1 72
8 2.002
Inf
0.546
0.403
0.0
0.546
0.01
-0.000401
1.0
0.595
Inf
0.597
0.638
0.0
0.597
0.01
-0.327
1.0
0.636
HCC38 Everolimus 2 72
sigmoid
flat
HCC38 everolimus 0 2 72
8 2.170
8323.0
0.58
0.376
0.000127
0.417
0.1
0.688
0.0303
NA
Inf
0.6
0.637
0.0
0.6
0.01
0.509
0.119
0.637
BT-549 Everolimus 2 72
flat
flat
BT549 everolimus 0 2 72
8 1.909
Inf
0.566
0.407
0.0
0.566
0.01
-0.646
1.0
0.594
Inf
0.627
0.648
0.0
0.627
0.01
-1.01
1.0
0.649
HCC38 Sirolimus 2 72
flat
flat
HCC38 rapamycin 0 2 72
8 2.106
Inf
0.588
0.371
0.0
0.588
0.01
0.496
0.128
0.629
Inf
0.616
0.65
0.0
0.616
0.01
0.246
0.429
0.649
HCC38 Sirolimus 1 72
flat
flat
HCC38 rapamycin 0 1 72
8 1.723
Inf
0.531
0.429
0.0
0.531
0.01
0.623
0.0538
0.573
Inf
0.631
0.66
0.0
0.631
0.01
0.536
0.0998
0.661
HCC38 Everolimus 1 72
sigmoid
flat
HCC38 everolimus 0 1 72
8 1.703
11.8
0.54
0.428
0.000126
0.341
0.1
0.688
0.0303
NA
Inf
0.641
0.664
0.0
0.641
0.01
0.571
0.0788
0.665
BT-549 Sirolimus 2 72
flat
flat
BT549 rapamycin 0 2 72
8 1.830
Inf
0.569
0.384
0.0
0.569
0.01
0.517
0.113
0.618
Inf
0.642
0.677
0.0
0.642
0.01
0.465
0.153
0.679
BT-549 Everolimus 3 72
sigmoid
flat
BT549 everolimus 0 3 72
8 1.587
59.5
0.533
0.425
1e-05
0.395
0.1
0.702
0.0264
NA
Inf
0.656
0.685
0.0
0.656
0.01
0.48
0.141
0.685
HCC70 Everolimus 1 72
flat
flat
HCC70 everolimus 0 1 72
8 1.366
Inf
0.569
0.354
0.0
0.569
0.01
0.623
0.0534
0.643
Inf
0.718
0.766
0.0
0.718
0.01
0.62
0.0547
0.765
HCC70 Sirolimus 2 72
flat
flat
HCC70 rapamycin 0 2 72
8 1.762
Inf
0.685
0.257
0.0
0.685
0.01
0.531
0.103
0.741
Inf
0.739
0.785
0.0
0.739
0.01
0.524
0.108
0.783
BT-20 BX-912 2 72
flat
flat
BT20 BX-912 0 2 72
8 1.873
Inf
0.683
0.213
0.0
0.683
0.01
0.118
0.686
0.777
Inf
0.724
0.81
0.0
0.724
0.01
0.111
0.702
0.802
HCC70 Everolimus 2 72
flat
flat
HCC70 everolimus 0 2 72
8 1.730
Inf
0.674
0.227
0.0
0.674
0.01
0.271
0.388
0.766
Inf
0.735
0.812
0.0
0.735
0.01
0.264
0.399
0.807
Hs 578T Alpelisib 2
flat
flat
Hs578T alpelisib 2
8 2.513
Inf
0.668
0.131
0.0
0.668
0.01
0.599
0.0647
0.856
Inf
0.634
0.847
0.0
0.634
0.01
0.541
0.0969
0.833
BT-20 XL147 3 72
flat
flat
BT20 pilaralisib 0 3 72
8 2.647
Inf
0.755
0.102
0.0
0.755
0.01
0.0679
0.81
0.885
Inf
0.708
0.871
0.0
0.708
0.01
0.0505
0.856
0.857
BT-20 BX-912 3 72
flat
flat
BT20 BX-912 0 3 72
8 2.619
Inf
0.904
0.0795
0.0
0.904
0.01
0.000173
0.999
0.918
Inf
0.879
0.9
0.0
0.879
0.01
0.00619
0.982
0.896
BT-20 BX-912 1 72
flat
flat
BT20 BX-912 0 1 72
8 2.193
Inf
0.858
0.0928
0.0
0.858
0.01
0.25
0.422
0.903
Inf
0.851
0.901
0.0
0.851
0.01
0.243
0.433
0.897
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