Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC1806 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC1806 rapamycin 0 3 72 | 8 | 3.249 | 0.223 | 0.805 | 0.162 | 0.000183 | 0.746 | 0.1 | 0.663 | 0.0382 | NA | 1.05 | 0.717 | 0.76 | 1e-05 | 0.657 | 0.1 | 0.68 | 0.0328 | NA |
HCC1806 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 3 72 | 8 | 3.242 | Inf | 0.531 | 0.255 | 0.0458 | 0.517 | 0.885 | 0.997 | 3.48e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | Everolimus | 3 | 72 | sigmoid | sigmoid | HCC1806 everolimus 0 3 72 | 8 | 3.239 | Inf | 0.813 | 0.159 | 0.000271 | 0.812 | 0.356 | 0.879 | 0.00175 | NA | Inf | 0.727 | 0.765 | 0.00022 | 0.729 | 0.377 | 0.879 | 0.00177 | NA |
HCC1806 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 3 72 | 8 | 3.234 | 14.1 | 0.818 | 0.0423 | 52.2 | -0.98 | 0.831 | 0.814 | 0.00649 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
HCC1806 | Alpelisib | 3 | 72 | flat | flat | HCC1806 alpelisib 0 3 72 | 8 | 3.224 | Inf | 0.93 | 0.0502 | 0.0 | 0.93 | 0.01 | -0.335 | 1.0 | 0.948 | Inf | 0.891 | 0.921 | 0.0 | 0.891 | 0.01 | -0.351 | 1.0 | 0.919 |
HCC1806 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 3 72 | 8 | 3.217 | 0.147 | -0.221 | 0.437 | 0.71 | -0.707 | 0.559 | 0.981 | 7.41e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Torin2 | 3 | 72 | sigmoid | sigmoid | HCC1806 Torin2 0 3 72 | 8 | 3.212 | 0.0678 | -0.0927 | 0.522 | 0.0798 | -0.12 | 1.32 | 0.996 | 6.56e-08 | NA | 0.0486 | 0.079 | 0.492 | 0.0442 | 0.0528 | 1.17 | 0.995 | 1.09e-07 | NA |
HCC1806 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC1806 Torin1 0 3 72 | 8 | 3.208 | 0.537 | 0.332 | 0.278 | 0.165 | 0.271 | 0.662 | 0.988 | 1.91e-06 | NA | 0.186 | 0.272 | 0.651 | 0.0697 | 0.26 | 0.75 | 0.992 | 4.55e-07 | NA |
HCC1806 | PIK-93 | 3 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 3 72 | 8 | 3.206 | 56.0 | 0.873 | 0.0337 | 320.0 | -0.872 | 0.579 | 0.859 | 0.00279 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
HCC1806 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 3 72 | 8 | 3.204 | Inf | 0.822 | 0.12 | 0.00981 | 0.829 | 0.872 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC1806 | AZD-6482 | 3 | 72 | flat | flat | HCC1806 AZD6482 0 3 72 | 8 | 3.201 | Inf | 1.0 | 0.00122 | 0.0 | 1.0 | 0.01 | -0.0063 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
HCC1806 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 3 72 | 8 | 3.199 | 74.1 | 0.843 | 0.0434 | 320.0 | -0.491 | 0.468 | 0.981 | 6.96e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.46e-05 | NA |
HCC1806 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC1806 dactolisib 0 3 72 | 8 | 3.196 | 0.193 | 0.0324 | 0.393 | 0.437 | -0.302 | 0.579 | 0.986 | 2.91e-06 | NA | 0.0977 | 0.121 | 0.559 | 0.093 | 0.0151 | 0.619 | 0.986 | 2.47e-06 | NA |
HCC1806 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 3 72 | 8 | 3.195 | 0.808 | -0.257 | 0.203 | 0.96 | -0.303 | 2.74 | 1.0 | 2.03e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
HCC1806 | KIN001-244 | 3 | 72 | flat | flat | HCC1806 KIN001-244 0 3 72 | 8 | 3.195 | Inf | 0.988 | 0.0203 | 0.0 | 0.988 | 0.01 | -0.0575 | 1.0 | 0.982 | Inf | 0.981 | 0.968 | 0.0 | 0.981 | 0.01 | -0.0553 | 1.0 | 0.972 |
HCC1806 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC1806 BX-912 0 3 72 | 8 | 3.193 | 1.09 | 0.234 | 0.126 | 0.897 | 0.217 | 2.99 | 0.999 | 2.85e-09 | NA | 0.894 | 0.214 | 0.853 | 0.753 | 0.205 | 3.07 | 0.997 | 2.86e-08 | NA |
HCC1806 | XL147 | 3 | 72 | flat | flat | HCC1806 pilaralisib 0 3 72 | 8 | 3.185 | Inf | 1.02 | 0.000871 | 0.0 | 1.02 | 0.01 | -2.12e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
HCC1806 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 3 72 | 8 | 3.185 | Inf | 0.593 | 0.215 | 0.0523 | 0.583 | 1.19 | 0.995 | 1.36e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC1806 AS-605240 0 3 72 | 8 | 3.181 | Inf | 0.923 | 0.011 | 0.57 | 0.923 | 2.81 | 0.936 | 0.000257 | NA | Inf | 0.883 | 0.983 | 0.559 | 0.882 | 2.81 | 0.931 | 0.000333 | NA |
HCC1806 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 3 72 | 8 | 3.162 | Inf | 0.654 | 0.0322 | 1.18 | 0.65 | 4.68 | 0.99 | 1.03e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
HCC1806 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 3 72 | 8 | 3.149 | 1.8 | 0.418 | 0.132 | 0.77 | 0.31 | 1.14 | 0.995 | 1.41e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC1806 | CAL-101 | 3 | 72 | flat | flat | HCC1806 idelalisib 0 3 72 | 8 | 3.147 | Inf | 1.02 | -0.00869 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
HCC1806 | TGX221 | 3 | 72 | flat | flat | HCC1806 TGX-221 0 3 72 | 8 | 3.132 | Inf | 1.0 | -0.0101 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
HCC1806 | PI103 | 3 | 72 | sigmoid | sigmoid | HCC1806 PI-103 0 3 72 | 8 | 3.126 | Inf | 0.91 | 0.00588 | 1.72 | 0.873 | 1.43 | 0.782 | 0.0103 | NA | Inf | 0.866 | 0.992 | 1.61 | 0.817 | 1.44 | 0.762 | 0.0134 | NA |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA |