Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC70 | XL147 | 1 | 72 | flat | flat | HCC70 pilaralisib 0 1 72 | 8 | 1.396 | Inf | 1.05 | -0.0406 | 0.0 | 1.05 | 0.01 | -0.285 | 1.0 | 1.03 | Inf | 1.04 | 1.03 | 0.0 | 1.04 | 0.01 | -0.295 | 1.0 | 1.02 |
HCC70 | XL147 | 3 | 72 | flat | flat | HCC70 pilaralisib 0 3 72 | 8 | 2.478 | Inf | 1.03 | -0.0199 | 0.0 | 1.03 | 0.01 | -0.318 | 1.0 | 1.02 | Inf | 1.03 | 1.03 | 0.0 | 1.03 | 0.01 | -0.331 | 1.0 | 1.02 |
HCC1806 | XL147 | 3 | 72 | flat | flat | HCC1806 pilaralisib 0 3 72 | 8 | 3.185 | Inf | 1.02 | 0.000871 | 0.0 | 1.02 | 0.01 | -2.12e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
BT-20 | TGX221 | 1 | 72 | flat | flat | BT20 TGX-221 0 1 72 | 8 | 1.988 | Inf | 1.02 | -0.00357 | 0.0 | 1.02 | 0.01 | -0.00762 | 1.0 | 1.0 | Inf | 1.02 | 1.0 | 0.0 | 1.02 | 0.01 | -0.00881 | 1.0 | 1.0 |
HCC1806 | XL147 | 2 | 72 | flat | flat | HCC1806 pilaralisib 0 2 72 | 8 | 2.817 | Inf | 1.02 | 0.000975 | 0.0 | 1.02 | 0.01 | -4.46e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000109 | 1.0 | 1.0 |
HCC1806 | CAL-101 | 2 | 72 | flat | flat | HCC1806 idelalisib 0 2 72 | 8 | 2.779 | Inf | 1.02 | -0.00985 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.588 | 1.0 | 1.02 |
HCC1806 | CAL-101 | 1 | 72 | flat | flat | HCC1806 idelalisib 0 1 72 | 8 | 2.695 | Inf | 1.02 | -0.0102 | 0.0 | 1.02 | 0.01 | -0.593 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
HCC1806 | CAL-101 | 3 | 72 | flat | flat | HCC1806 idelalisib 0 3 72 | 8 | 3.147 | Inf | 1.02 | -0.00869 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
HCC1806 | XL147 | 1 | 72 | flat | flat | HCC1806 pilaralisib 0 1 72 | 8 | 2.732 | Inf | 1.02 | 0.00101 | 0.0 | 1.02 | 0.01 | -4.53e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
HCC1806 | TGX221 | 2 | 72 | flat | flat | HCC1806 TGX-221 0 2 72 | 8 | 2.763 | Inf | 1.0 | -0.0114 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
BT-20 | TGX221 | 2 | 72 | flat | flat | BT20 TGX-221 0 2 72 | 8 | 1.656 | Inf | 1.0 | 0.0477 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.946 | Inf | 1.0 | 0.961 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.956 |
HCC1806 | TGX221 | 3 | 72 | flat | flat | HCC1806 TGX-221 0 3 72 | 8 | 3.132 | Inf | 1.0 | -0.0101 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
HCC1806 | TGX221 | 1 | 72 | flat | flat | HCC1806 TGX-221 0 1 72 | 8 | 2.679 | Inf | 1.0 | -0.0118 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
HCC1806 | AZD-6482 | 2 | 72 | flat | flat | HCC1806 AZD6482 0 2 72 | 8 | 2.833 | Inf | 1.0 | 0.00136 | 0.0 | 1.0 | 0.01 | -0.0062 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00512 | 1.0 | 0.998 |
HCC1806 | AZD-6482 | 1 | 72 | flat | flat | HCC1806 AZD6482 0 1 72 | 8 | 2.748 | Inf | 1.0 | 0.00141 | 0.0 | 1.0 | 0.01 | -0.00621 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
HCC1806 | AZD-6482 | 3 | 72 | flat | flat | HCC1806 AZD6482 0 3 72 | 8 | 3.201 | Inf | 1.0 | 0.00122 | 0.0 | 1.0 | 0.01 | -0.0063 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
BT-20 | MK2206 | 2 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 2 72 | 8 | 1.739 | 0.823 | 0.0896 | 0.246 | 4.34 | -1.0 | 0.661 | 0.965 | 4.36e-05 | NA | 1.47 | 0.348 | 0.806 | 1.47 | 0.0 | 0.715 | 0.947 | 0.000145 | NA |
BT-20 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT20 Torin2 0 3 72 | 8 | 2.458 | 0.019 | -0.64 | 0.751 | 0.234 | -1.0 | 0.438 | 0.959 | 6.92e-05 | NA | 0.0147 | 0.0148 | 0.379 | 0.0123 | 0.0598 | 0.727 | 0.977 | 1.28e-05 | NA |
BT-20 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT20 PIK-93 0 2 72 | 8 | 1.798 | 0.792 | 0.155 | 0.286 | 14.1 | -1.0 | 0.382 | 0.81 | 0.00687 | NA | 2.8 | 0.373 | 0.764 | 2.8 | 0.0 | 0.344 | 0.77 | 0.0121 | NA |
BT-20 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 3 72 | 8 | 2.601 | 1.68 | 0.3 | 0.173 | 8.38 | -1.0 | 0.685 | 0.959 | 6.72e-05 | NA | 1.5 | 0.326 | 0.805 | 1.5 | 0.0 | 0.733 | 0.925 | 0.000414 | NA |
BT-549 | Pictilisib | 2 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 2 72 | 8 | 1.960 | 1.84 | 0.365 | 0.166 | 11.5 | -1.0 | 0.599 | 0.943 | 0.000187 | NA | 2.82 | 0.473 | 0.851 | 2.82 | 0.0 | 0.647 | 0.924 | 0.000432 | NA |
BT-549 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 2 72 | 8 | 1.983 | 7.03 | 0.687 | 0.0641 | 29.9 | -1.0 | 0.759 | 0.956 | 8.81e-05 | NA | 10.4 | 0.713 | 0.939 | 10.4 | 0.0 | 0.788 | 0.949 | 0.000136 | NA |
BT-549 | PIK-93 | 3 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 3 72 | 8 | 1.807 | 20.1 | 0.719 | 0.0848 | 231.0 | -1.0 | 0.45 | 0.716 | 0.0229 | NA | 67.9 | 0.761 | 0.925 | 67.9 | 0.0 | 0.431 | 0.686 | 0.0309 | NA |
BT-20 | Pictilisib | 2 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 2 72 | 8 | 1.746 | 0.308 | -0.0521 | 0.379 | 2.35 | -1.0 | 0.54 | 0.791 | 0.00908 | NA | 0.634 | 0.272 | 0.712 | 0.634 | 0.0 | 0.6 | 0.716 | 0.0229 | NA |