Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | XL147 | 1 | 72 | flat | flat | BT20 pilaralisib 0 1 72 | 8 | 2.128 | Inf | 0.815 | 0.048 | 0.0 | 0.815 | 0.01 | 0.411 | 0.205 | 0.939 | Inf | 0.813 | 0.95 | 0.0 | 0.813 | 0.01 | 0.383 | 0.234 | 0.937 |
BT-20 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT20 trametinib 0 3 72 | 8 | 2.539 | Inf | 0.64 | 0.208 | 0.104 | 0.541 | 0.392 | 0.967 | 3.69e-05 | NA | Inf | 0.604 | 0.761 | 0.0656 | 0.513 | 0.391 | 0.964 | 4.56e-05 | NA |
BT-20 | Everolimus | 1 | 72 | flat | flat | BT20 everolimus 0 1 72 | 8 | 2.002 | Inf | 0.546 | 0.403 | 0.0 | 0.546 | 0.01 | -0.000401 | 1.0 | 0.595 | Inf | 0.597 | 0.638 | 0.0 | 0.597 | 0.01 | -0.327 | 1.0 | 0.636 |
BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
BT-20 | TGX221 | 2 | 72 | flat | flat | BT20 TGX-221 0 2 72 | 8 | 1.656 | Inf | 1.0 | 0.0477 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.946 | Inf | 1.0 | 0.961 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.956 |
BT-20 | KIN001-244 | 3 | 72 | flat | flat | BT20 KIN001-244 0 3 72 | 8 | 2.608 | Inf | 0.841 | 0.062 | 0.0 | 0.841 | 0.01 | 0.489 | 0.133 | 0.935 | Inf | 0.805 | 0.922 | 0.0 | 0.805 | 0.01 | 0.475 | 0.145 | 0.919 |
BT-20 | AS605240 | 1 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 1 72 | 8 | 2.142 | Inf | 0.817 | 0.0993 | 3.91 | 0.634 | 0.244 | 0.861 | 0.00271 | NA | Inf | 0.814 | 0.897 | 3.87 | 0.629 | 0.237 | 0.854 | 0.00311 | NA |
BT-20 | Sirolimus | 3 | 72 | flat | flat | BT20 rapamycin 0 3 72 | 8 | 2.661 | Inf | 0.54 | 0.46 | 0.0 | 0.54 | 0.01 | NA | NA | 0.54 | Inf | 0.499 | 0.499 | 0.0 | 0.499 | 0.01 | NA | NA | 0.499 |
BT-20 | Sirolimus | 2 | 72 | flat | flat | BT20 rapamycin 0 2 72 | 8 | 1.952 | Inf | 0.421 | 0.579 | 0.0 | 0.421 | 0.01 | NA | NA | 0.421 | Inf | 0.513 | 0.513 | 0.0 | 0.513 | 0.01 | NA | NA | 0.513 |
BT-20 | Everolimus | 2 | 72 | flat | flat | BT20 everolimus 0 2 72 | 8 | 1.785 | Inf | 0.426 | 0.574 | 0.0 | 0.426 | 0.01 | NA | NA | 0.426 | Inf | 0.547 | 0.547 | 0.0 | 0.547 | 0.01 | NA | NA | 0.547 |
BT-20 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 3 72 | 8 | 2.607 | Inf | 0.845 | 0.0823 | 4.13 | 0.662 | 0.292 | 0.729 | 0.0199 | NA | Inf | 0.81 | 0.897 | 3.97 | 0.589 | 0.284 | 0.712 | 0.0239 | NA |
BT-20 | TGX221 | 1 | 72 | flat | flat | BT20 TGX-221 0 1 72 | 8 | 1.988 | Inf | 1.02 | -0.00357 | 0.0 | 1.02 | 0.01 | -0.00762 | 1.0 | 1.0 | Inf | 1.02 | 1.0 | 0.0 | 1.02 | 0.01 | -0.00881 | 1.0 | 1.0 |
BT-20 | MK2206 | 1 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 1 72 | 8 | 2.089 | Inf | 0.732 | 0.102 | 4.16 | 0.529 | 0.345 | 0.671 | 0.0357 | NA | Inf | 0.741 | 0.898 | 4.14 | 0.538 | 0.337 | 0.676 | 0.034 | NA |
BT-20 | Everolimus | 3 | 72 | flat | flat | BT20 everolimus 0 3 72 | 8 | 2.422 | Inf | 0.475 | 0.456 | 0.0 | 0.475 | 0.01 | 0.602 | 0.0632 | 0.543 | Inf | 0.478 | 0.534 | 0.0 | 0.478 | 0.01 | 0.561 | 0.0844 | 0.534 |
BT-20 | BX-912 | 1 | 72 | flat | flat | BT20 BX-912 0 1 72 | 8 | 2.193 | Inf | 0.858 | 0.0928 | 0.0 | 0.858 | 0.01 | 0.25 | 0.422 | 0.903 | Inf | 0.851 | 0.901 | 0.0 | 0.851 | 0.01 | 0.243 | 0.433 | 0.897 |
BT-20 | BX-912 | 2 | 72 | flat | flat | BT20 BX-912 0 2 72 | 8 | 1.873 | Inf | 0.683 | 0.213 | 0.0 | 0.683 | 0.01 | 0.118 | 0.686 | 0.777 | Inf | 0.724 | 0.81 | 0.0 | 0.724 | 0.01 | 0.111 | 0.702 | 0.802 |
BT-20 | BX-912 | 3 | 72 | flat | flat | BT20 BX-912 0 3 72 | 8 | 2.619 | Inf | 0.904 | 0.0795 | 0.0 | 0.904 | 0.01 | 0.000173 | 0.999 | 0.918 | Inf | 0.879 | 0.9 | 0.0 | 0.879 | 0.01 | 0.00619 | 0.982 | 0.896 |
BT-20 | KIN001-244 | 1 | 72 | flat | flat | BT20 KIN001-244 0 1 72 | 8 | 2.125 | Inf | 0.911 | 0.0401 | 0.0 | 0.911 | 0.01 | -0.00641 | 1.0 | 0.957 | Inf | 0.908 | 0.958 | 0.0 | 0.908 | 0.01 | -0.00745 | 1.0 | 0.955 |
BT-20 | Sirolimus | 1 | 72 | flat | flat | BT20 rapamycin 0 1 72 | 8 | 2.100 | Inf | 0.568 | 0.431 | 0.0 | 0.568 | 0.01 | -9.89 | 1.0 | 0.568 | Inf | 0.6 | 0.601 | 0.0 | 0.6 | 0.01 | -13.0 | 1.0 | 0.6 |
BT-20 | KIN001-244 | 2 | 72 | sigmoid | sigmoid | BT20 KIN001-244 0 2 72 | 8 | 1.742 | Inf | 0.85 | 0.0644 | 4.47 | 0.713 | 0.316 | 0.721 | 0.0218 | NA | Inf | 0.873 | 0.945 | 4.51 | 0.757 | 0.309 | 0.715 | 0.0231 | NA |
BT-20 | CAL-101 | 1 | 72 | flat | flat | BT20 idelalisib 0 1 72 | 8 | 2.112 | Inf | 0.869 | 0.0546 | 0.0 | 0.869 | 0.01 | 0.0807 | 0.777 | 0.938 | Inf | 0.867 | 0.943 | 0.0 | 0.867 | 0.01 | 0.0778 | 0.784 | 0.936 |
BT-20 | CAL-101 | 2 | 72 | flat | flat | BT20 idelalisib 0 2 72 | 8 | 1.768 | Inf | 0.818 | 0.0943 | 0.0 | 0.818 | 0.01 | 0.226 | 0.463 | 0.898 | Inf | 0.845 | 0.918 | 0.0 | 0.845 | 0.01 | 0.222 | 0.471 | 0.912 |
BT-20 | CAL-101 | 3 | 72 | flat | flat | BT20 idelalisib 0 3 72 | 8 | 2.589 | Inf | 0.916 | 0.0535 | 0.0 | 0.916 | 0.01 | 0.0547 | 0.845 | 0.944 | Inf | 0.894 | 0.932 | 0.0 | 0.894 | 0.01 | 0.0506 | 0.856 | 0.929 |
BT-20 | XL147 | 3 | 72 | flat | flat | BT20 pilaralisib 0 3 72 | 8 | 2.647 | Inf | 0.755 | 0.102 | 0.0 | 0.755 | 0.01 | 0.0679 | 0.81 | 0.885 | Inf | 0.708 | 0.871 | 0.0 | 0.708 | 0.01 | 0.0505 | 0.856 | 0.857 |
BT-20 | XL147 | 2 | 72 | flat | flat | BT20 pilaralisib 0 2 72 | 8 | 1.784 | Inf | 0.759 | 0.073 | 0.0 | 0.759 | 0.01 | -0.0058 | 1.0 | 0.907 | Inf | 0.796 | 0.937 | 0.0 | 0.796 | 0.01 | -0.00637 | 1.0 | 0.92 |