Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	PIK-93	2	72	sigmoid	sigmoid	HCC70 PIK-93 0 2 72	8	1.705	4.34	0.647	0.0132	9.3	-1.0	1.44	0.888	0.0014	NA	6.01	0.718	0.991	6.01	0.0	1.49	0.872	0.00208	NA
Hs 578T	TGX221	3		sigmoid	sigmoid	Hs578T TGX-221 3	8	2.818	24.2	0.885	0.0148	88.9	-1.0	0.843	0.958	7.66e-05	NA	23.4	0.846	0.98	23.4	0.0	0.862	0.953	0.000103	NA
Hs 578T	PIK-93	1		sigmoid	sigmoid	Hs578T PIK-93 1	8	2.033	1.44	0.276	0.175	8.38	-1.0	0.624	0.991	6.57e-07	NA	2.0	0.401	0.84	2.0	0.0	0.672	0.99	9.72e-07	NA
BT-20	AZD-6482	3	72	sigmoid	sigmoid	BT20 AZD6482 0 3 72	8	2.601	1.68	0.3	0.173	8.38	-1.0	0.685	0.959	6.72e-05	NA	1.5	0.326	0.805	1.5	0.0	0.733	0.925	0.000414	NA
BT-20	PIK-93	3	72	sigmoid	sigmoid	BT20 PIK-93 0 3 72	8	2.532	2.65	0.419	0.097	7.54	-1.0	1.05	0.982	5.47e-06	NA	2.5	0.42	0.892	2.5	0.0	1.17	0.971	2.45e-05	NA
Hs 578T	AZD-6482	2		sigmoid	sigmoid	Hs578T AZD6482 2	8	2.508	6.35	0.602	0.121	74.8	-1.0	0.445	0.998	1.12e-08	NA	6.4	0.573	0.86	6.4	0.0	0.475	0.996	6.36e-08	NA
BT-20	PIK-93	1	72	sigmoid	sigmoid	BT20 PIK-93 0 1 72	8	2.025	2.65	0.406	0.0864	6.54	-1.0	1.22	0.993	3.89e-07	NA	3.15	0.49	0.92	3.15	0.0	1.31	0.989	1.33e-06	NA
Hs 578T	ZSTK474	2		sigmoid	sigmoid	Hs578T ZSTK474 2	8	2.554	0.715	0.187	0.263	5.92	-0.896	0.485	0.995	1.27e-07	NA	0.583	0.264	0.722	0.583	0.0	0.56	0.993	3.28e-07	NA
BT-20	Alpelisib	3	72	sigmoid	sigmoid	BT20 alpelisib 0 3 72	8	2.541	1.21	0.199	0.21	5.83	-1.0	0.697	0.881	0.00167	NA	1.12	0.272	0.775	1.12	0.0	0.764	0.791	0.00916	NA
HCC1806	Pictilisib	3	72	sigmoid	sigmoid	HCC1806 pictilisib 0 3 72	8	3.234	14.1	0.818	0.0423	52.2	-0.98	0.831	0.814	0.00649	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
HCC38	ZSTK474	3	72	sigmoid	sigmoid	HCC38 ZSTK474 0 3 72	8	1.458	2.06	0.398	0.146	5.06	-0.41	0.665	0.989	1.23e-06	NA	6.44	0.593	0.898	3.35	0.179	0.678	0.988	1.64e-06	NA
Hs 578T	KIN001-244	3		sigmoid	sigmoid	Hs578T KIN001-244 3	8	2.888	Inf	0.866	0.00909	5.05	0.617	1.35	0.858	0.00289	NA	50.0	0.818	0.988	5.2	0.474	1.31	0.842	0.00391	NA
BT-20	Pictilisib	1	72	sigmoid	sigmoid	BT20 pictilisib 0 1 72	8	2.085	1.25	0.163	0.177	5.0	-1.0	0.791	0.994	1.75e-07	NA	1.52	0.323	0.838	1.52	0.0	0.865	0.989	1.22e-06	NA
BT-549	KIN001-244	1	72	sigmoid	sigmoid	BT549 KIN001-244 0 1 72	8	1.802	Inf	0.872	0.0273	4.85	0.695	0.794	0.852	0.00324	NA	Inf	0.888	0.976	4.84	0.733	0.786	0.846	0.00362	NA
BT-549	CAL-101	1	72	sigmoid	sigmoid	BT549 idelalisib 0 1 72	8	1.791	Inf	0.836	0.041	4.8	0.605	0.778	0.924	0.00044	NA	Inf	0.858	0.964	4.79	0.659	0.767	0.92	0.000518	NA
Hs 578T	KIN001-244	2		sigmoid	sigmoid	Hs578T KIN001-244 2	8	2.505	Inf	0.819	0.0357	4.8	0.531	1.14	0.891	0.0013	NA	44.3	0.788	0.957	4.79	0.457	1.1	0.878	0.0018	NA
HCC38	AZD-6482	2	72	sigmoid	sigmoid	HCC38 AZD6482 0 2 72	8	2.132	Inf	0.898	0.0351	4.71	0.773	0.497	0.824	0.0055	NA	Inf	0.894	0.963	4.7	0.765	0.492	0.82	0.00588	NA
BT-549	KIN001-244	3	72	sigmoid	sigmoid	BT549 KIN001-244 0 3 72	8	1.740	Inf	0.861	0.0287	4.69	0.681	0.74	0.922	0.00047	NA	Inf	0.882	0.975	4.7	0.729	0.732	0.919	0.000531	NA
BT-549	CAL-101	2	72	sigmoid	sigmoid	BT549 idelalisib 0 2 72	8	1.975	Inf	0.792	0.0561	4.65	0.526	0.693	0.933	0.000307	NA	43.0	0.805	0.946	43.0	0.0	0.548	0.932	0.000314	NA
BT-549	Pictilisib	3	72	sigmoid	sigmoid	BT549 pictilisib 0 3 72	8	1.767	1.42	0.276	0.169	4.62	-0.67	0.722	0.998	9.61e-09	NA	2.47	0.452	0.863	2.47	0.0	0.742	0.997	2.13e-08	NA
HCC38	TGX221	2	72	sigmoid	sigmoid	HCC38 TGX-221 0 2 72	8	2.116	Inf	0.908	0.0281	4.57	0.803	0.501	0.711	0.0242	NA	Inf	0.905	0.971	4.56	0.797	0.497	0.705	0.0256	NA
Hs 578T	CAL-101	1		sigmoid	sigmoid	Hs578T idelalisib 1	8	2.050	27.9	0.72	0.0764	4.56	0.356	0.688	0.945	0.000168	NA	18.7	0.734	0.925	18.7	0.0	0.568	0.941	0.000203	NA
HCC1806	Pictilisib	2	72	sigmoid	sigmoid	HCC1806 pictilisib 0 2 72	8	2.866	12.1	0.796	0.0476	45.4	-1.0	0.831	0.811	0.00671	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
BT-549	AS605240	1	72	sigmoid	sigmoid	BT549 AS-605240 0 1 72	8	1.804	Inf	0.893	0.0436	4.49	0.778	0.375	0.862	0.00261	NA	Inf	0.905	0.961	4.52	0.804	0.371	0.861	0.00267	NA
BT-20	KIN001-244	2	72	sigmoid	sigmoid	BT20 KIN001-244 0 2 72	8	1.742	Inf	0.85	0.0644	4.47	0.713	0.316	0.721	0.0218	NA	Inf	0.873	0.945	4.51	0.757	0.309	0.715	0.0231	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)