Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | XL147 | 1 | 72 | flat | flat | HCC70 pilaralisib 0 1 72 | 8 | 1.396 | Inf | 1.05 | -0.0406 | 0.0 | 1.05 | 0.01 | -0.285 | 1.0 | 1.03 | Inf | 1.04 | 1.03 | 0.0 | 1.04 | 0.01 | -0.295 | 1.0 | 1.02 |
| HCC1806 | XL147 | 3 | 72 | flat | flat | HCC1806 pilaralisib 0 3 72 | 8 | 3.185 | Inf | 1.02 | 0.000871 | 0.0 | 1.02 | 0.01 | -2.12e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
| HCC1806 | CAL-101 | 3 | 72 | flat | flat | HCC1806 idelalisib 0 3 72 | 8 | 3.147 | Inf | 1.02 | -0.00869 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
| HCC1806 | XL147 | 2 | 72 | flat | flat | HCC1806 pilaralisib 0 2 72 | 8 | 2.817 | Inf | 1.02 | 0.000975 | 0.0 | 1.02 | 0.01 | -4.46e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000109 | 1.0 | 1.0 |
| HCC1806 | CAL-101 | 2 | 72 | flat | flat | HCC1806 idelalisib 0 2 72 | 8 | 2.779 | Inf | 1.02 | -0.00985 | 0.0 | 1.02 | 0.01 | -0.594 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.588 | 1.0 | 1.02 |
| HCC1806 | XL147 | 1 | 72 | flat | flat | HCC1806 pilaralisib 0 1 72 | 8 | 2.732 | Inf | 1.02 | 0.00101 | 0.0 | 1.02 | 0.01 | -4.53e-06 | 1.0 | 1.0 | Inf | 1.03 | 0.999 | 0.0 | 1.03 | 0.01 | -0.000107 | 1.0 | 1.0 |
| HCC1806 | CAL-101 | 1 | 72 | flat | flat | HCC1806 idelalisib 0 1 72 | 8 | 2.695 | Inf | 1.02 | -0.0102 | 0.0 | 1.02 | 0.01 | -0.593 | 1.0 | 1.01 | Inf | 1.03 | 1.01 | 0.0 | 1.03 | 0.01 | -0.587 | 1.0 | 1.02 |
| HCC70 | XL147 | 3 | 72 | flat | flat | HCC70 pilaralisib 0 3 72 | 8 | 2.478 | Inf | 1.03 | -0.0199 | 0.0 | 1.03 | 0.01 | -0.318 | 1.0 | 1.02 | Inf | 1.03 | 1.03 | 0.0 | 1.03 | 0.01 | -0.331 | 1.0 | 1.02 |
| BT-20 | TGX221 | 1 | 72 | flat | flat | BT20 TGX-221 0 1 72 | 8 | 1.988 | Inf | 1.02 | -0.00357 | 0.0 | 1.02 | 0.01 | -0.00762 | 1.0 | 1.0 | Inf | 1.02 | 1.0 | 0.0 | 1.02 | 0.01 | -0.00881 | 1.0 | 1.0 |
| HCC1806 | AZD-6482 | 1 | 72 | flat | flat | HCC1806 AZD6482 0 1 72 | 8 | 2.748 | Inf | 1.0 | 0.00141 | 0.0 | 1.0 | 0.01 | -0.00621 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
| HCC1806 | AZD-6482 | 2 | 72 | flat | flat | HCC1806 AZD6482 0 2 72 | 8 | 2.833 | Inf | 1.0 | 0.00136 | 0.0 | 1.0 | 0.01 | -0.0062 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00512 | 1.0 | 0.998 |
| HCC1806 | AZD-6482 | 3 | 72 | flat | flat | HCC1806 AZD6482 0 3 72 | 8 | 3.201 | Inf | 1.0 | 0.00122 | 0.0 | 1.0 | 0.01 | -0.0063 | 1.0 | 0.999 | Inf | 1.01 | 0.998 | 0.0 | 1.01 | 0.01 | -0.00515 | 1.0 | 0.998 |
| BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
| HCC1806 | TGX221 | 2 | 72 | flat | flat | HCC1806 TGX-221 0 2 72 | 8 | 2.763 | Inf | 1.0 | -0.0114 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
| BT-20 | TGX221 | 2 | 72 | flat | flat | BT20 TGX-221 0 2 72 | 8 | 1.656 | Inf | 1.0 | 0.0477 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.946 | Inf | 1.0 | 0.961 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.956 |
| HCC1806 | TGX221 | 1 | 72 | flat | flat | HCC1806 TGX-221 0 1 72 | 8 | 2.679 | Inf | 1.0 | -0.0118 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
| HCC1806 | TGX221 | 3 | 72 | flat | flat | HCC1806 TGX-221 0 3 72 | 8 | 3.132 | Inf | 1.0 | -0.0101 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.01 | Inf | 1.0 | 1.02 | 0.0 | 1.0 | 0.01 | -1.16 | 1.0 | 1.02 |
| HCC1806 | KIN001-244 | 1 | 72 | flat | flat | HCC1806 KIN001-244 0 1 72 | 8 | 2.742 | Inf | 0.986 | 0.0236 | 0.0 | 0.986 | 0.01 | -0.0573 | 1.0 | 0.979 | Inf | 0.981 | 0.968 | 0.0 | 0.981 | 0.01 | -0.0553 | 1.0 | 0.972 |
| HCC1806 | KIN001-244 | 3 | 72 | flat | flat | HCC1806 KIN001-244 0 3 72 | 8 | 3.195 | Inf | 0.988 | 0.0203 | 0.0 | 0.988 | 0.01 | -0.0575 | 1.0 | 0.982 | Inf | 0.981 | 0.968 | 0.0 | 0.981 | 0.01 | -0.0553 | 1.0 | 0.972 |
| HCC1806 | KIN001-244 | 2 | 72 | flat | flat | HCC1806 KIN001-244 0 2 72 | 8 | 2.827 | Inf | 0.986 | 0.0229 | 0.0 | 0.986 | 0.01 | -0.0574 | 1.0 | 0.98 | Inf | 0.981 | 0.968 | 0.0 | 0.981 | 0.01 | -0.0553 | 1.0 | 0.972 |
| HCC38 | AS605240 | 3 | 72 | flat | flat | HCC38 AS-605240 0 3 72 | 8 | 1.343 | Inf | 0.958 | -0.0162 | 0.0 | 0.958 | 0.01 | -0.233 | 1.0 | 1.01 | Inf | 0.972 | 1.01 | 0.0 | 0.972 | 0.01 | -0.235 | 1.0 | 1.01 |
| Hs 578T | XL147 | 2 | flat | flat | Hs578T pilaralisib 2 | 8 | 2.509 | Inf | 0.976 | 0.000255 | 0.0 | 0.976 | 0.01 | 0.435 | 0.181 | 0.997 | Inf | 0.97 | 1.0 | 0.0 | 0.97 | 0.01 | 0.432 | 0.183 | 0.996 | |
| HCC70 | XL147 | 2 | 72 | flat | flat | HCC70 pilaralisib 0 2 72 | 8 | 1.789 | Inf | 0.966 | 0.0311 | 0.0 | 0.966 | 0.01 | -0.12 | 1.0 | 0.965 | Inf | 0.97 | 0.973 | 0.0 | 0.97 | 0.01 | -0.121 | 1.0 | 0.969 |
| BT-549 | XL147 | 2 | 72 | flat | flat | BT549 pilaralisib 0 2 72 | 8 | 1.952 | Inf | 0.967 | -0.00824 | 0.0 | 0.967 | 0.01 | -0.000427 | 1.0 | 1.0 | Inf | 0.968 | 1.01 | 0.0 | 0.968 | 0.01 | -0.000878 | 1.0 | 1.0 |
| Hs 578T | XL147 | 1 | flat | flat | Hs578T pilaralisib 1 | 8 | 2.013 | Inf | 0.967 | 0.00411 | 0.0 | 0.967 | 0.01 | 0.193 | 0.525 | 0.991 | Inf | 0.967 | 0.996 | 0.0 | 0.967 | 0.01 | 0.196 | 0.519 | 0.991 |