Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	Pictilisib	2	72	sigmoid	sigmoid	BT549 pictilisib 0 2 72	8	1.960	1.84	0.365	0.166	11.5	-1.0	0.599	0.943	0.000187	NA	2.82	0.473	0.851	2.82	0.0	0.647	0.924	0.000432	NA
BT-549	Pictilisib	3	72	sigmoid	sigmoid	BT549 pictilisib 0 3 72	8	1.767	1.42	0.276	0.169	4.62	-0.67	0.722	0.998	9.61e-09	NA	2.47	0.452	0.863	2.47	0.0	0.742	0.997	2.13e-08	NA
BT-549	GDC-0980	1	72	sigmoid	sigmoid	BT549 apitolisib 0 1 72	8	1.781	0.19	0.113	0.333	0.16	0.1	1.27	0.999	4.05e-10	NA	0.328	0.352	0.744	0.132	0.347	1.31	0.999	7.05e-10	NA
BT-549	GDC-0980	2	72	sigmoid	sigmoid	BT549 apitolisib 0 2 72	8	1.939	0.189	0.0264	0.357	0.193	-0.011	1.04	0.997	2.98e-08	NA	0.278	0.274	0.71	0.142	0.257	1.07	0.997	3.64e-08	NA
BT-549	GDC-0980	3	72	sigmoid	sigmoid	BT549 apitolisib 0 3 72	8	1.802	0.162	0.0283	0.377	0.158	0.0179	1.2	0.994	2.53e-07	NA	0.268	0.302	0.709	0.128	0.294	1.2	0.992	4.85e-07	NA
BT-549	Omipalisib	1	72	sigmoid	sigmoid	BT549 omipalisib 0 1 72	8	1.789	0.0164	-0.2	0.693	0.0219	-0.149	0.887	0.986	2.66e-06	NA	0.0272	0.194	0.495	0.0148	0.228	0.993	0.991	8.42e-07	NA
BT-549	Omipalisib	2	72	sigmoid	sigmoid	BT549 omipalisib 0 2 72	8	1.990	0.0104	-0.291	0.751	0.026	-0.32	0.542	0.966	4.09e-05	NA	0.0175	0.127	0.422	0.011	0.118	0.58	0.953	0.000102	NA
BT-549	Omipalisib	3	72	sigmoid	sigmoid	BT549 omipalisib 0 3 72	8	1.777	0.0114	-0.23	0.753	0.0162	-0.178	0.879	0.988	1.64e-06	NA	0.0201	0.183	0.459	0.0112	0.208	0.924	0.991	6.53e-07	NA
BT-549	KIN001-244	1	72	sigmoid	sigmoid	BT549 KIN001-244 0 1 72	8	1.802	Inf	0.872	0.0273	4.85	0.695	0.794	0.852	0.00324	NA	Inf	0.888	0.976	4.84	0.733	0.786	0.846	0.00362	NA
BT-549	KIN001-244	2	72	sigmoid	sigmoid	BT549 KIN001-244 0 2 72	8	1.920	Inf	0.882	0.00561	2.72	0.793	1.67	0.73	0.0197	NA	Inf	0.89	0.995	2.6	0.813	1.68	0.718	0.0225	NA
BT-549	KIN001-244	3	72	sigmoid	sigmoid	BT549 KIN001-244 0 3 72	8	1.740	Inf	0.861	0.0287	4.69	0.681	0.74	0.922	0.00047	NA	Inf	0.882	0.975	4.7	0.729	0.732	0.919	0.000531	NA
BT-549	MK2206	1	72	sigmoid	sigmoid	BT549 MK-2206 0 1 72	8	1.811	Inf	0.632	0.189	0.103	0.58	0.8	0.911	0.000695	NA	Inf	0.692	0.839	0.101	0.642	0.73	0.911	0.000717	NA
BT-549	MK2206	2	72	sigmoid	sigmoid	BT549 MK-2206 0 2 72	8	1.871	Inf	0.926	0.0188	0.107	0.926	5.0	0.816	0.00627	NA	Inf	0.932	0.983	0.107	0.931	5.0	0.809	0.00694	NA
BT-549	MK2206	3	72	sigmoid	sigmoid	BT549 MK-2206 0 3 72	8	1.685	Inf	0.714	0.131	0.123	0.711	3.44	0.953	0.000102	NA	Inf	0.771	0.895	0.123	0.768	3.25	0.949	0.000136	NA
BT-549	PI103	1	72	sigmoid	sigmoid	BT549 PI-103 0 1 72	8	1.795	0.206	0.0898	0.34	0.185	0.0628	1.25	0.997	2.96e-08	NA	0.348	0.336	0.737	0.155	0.318	1.25	0.996	8.76e-08	NA
BT-549	PI103	2	72	sigmoid	sigmoid	BT549 PI-103 0 2 72	8	1.893	0.218	0.0201	0.344	0.229	-0.0262	1.08	0.997	2.55e-08	NA	0.326	0.28	0.725	0.169	0.261	1.13	0.996	6.2e-08	NA
BT-549	PI103	3	72	sigmoid	sigmoid	BT549 PI-103 0 3 72	8	1.758	0.16	0.00249	0.391	0.166	-0.0225	1.12	0.989	1.19e-06	NA	0.279	0.297	0.704	0.134	0.28	1.12	0.985	3.23e-06	NA
BT-549	PIK-93	1	72	sigmoid	sigmoid	BT549 PIK-93 0 1 72	8	1.777	Inf	0.691	0.0438	1.77	0.561	1.47	0.989	1.31e-06	NA	Inf	0.742	0.963	1.64	0.646	1.47	0.988	1.83e-06	NA
BT-549	PIK-93	2	72	sigmoid	sigmoid	BT549 PIK-93 0 2 72	8	1.983	7.03	0.687	0.0641	29.9	-1.0	0.759	0.956	8.81e-05	NA	10.4	0.713	0.939	10.4	0.0	0.788	0.949	0.000136	NA
BT-549	PIK-93	3	72	sigmoid	sigmoid	BT549 PIK-93 0 3 72	8	1.807	20.1	0.719	0.0848	231.0	-1.0	0.45	0.716	0.0229	NA	67.9	0.761	0.925	67.9	0.0	0.431	0.686	0.0309	NA
BT-549	Sirolimus	1	72	sigmoid	sigmoid	BT549 rapamycin 0 1 72	8	1.817	3.62	0.51	0.438	0.000148	0.318	0.1	0.87	0.00218	NA	506850.0	0.6	0.638	8.82e-05	0.447	0.1	0.8	0.00802	NA
BT-549	Sirolimus	2	72	flat	flat	BT549 rapamycin 0 2 72	8	1.830	Inf	0.569	0.384	0.0	0.569	0.01	0.517	0.113	0.618	Inf	0.642	0.677	0.0	0.642	0.01	0.465	0.153	0.679
BT-549	Sirolimus	3	72	flat	flat	BT549 rapamycin 0 3 72	8	1.703	Inf	0.455	0.482	0.0	0.455	0.01	0.376	0.243	0.518	Inf	0.582	0.626	0.0	0.582	0.01	0.436	0.179	0.625
BT-549	TGX221	1	72	sigmoid	sigmoid	BT549 TGX-221 0 1 72	8	1.826	Inf	0.821	0.0771	0.297	0.777	0.632	0.868	0.00232	NA	Inf	0.842	0.931	0.313	0.799	0.603	0.863	0.00255	NA
BT-549	TGX221	2	72	sigmoid	sigmoid	BT549 TGX-221 0 2 72	8	1.927	17.5	0.772	0.0551	123.0	-1.0	0.562	0.907	0.000795	NA	32.3	0.792	0.949	32.3	3.45e-05	0.58	0.899	0.00102	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)