Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC1806	Trametinib	3	72	sigmoid	sigmoid	HCC1806 trametinib 0 3 72	8	3.204	Inf	0.822	0.12	0.00981	0.829	0.872	0.97	2.67e-05	NA	Inf	0.742	0.822	0.00864	0.752	0.892	0.97	2.67e-05	NA
HCC1806	WYE-125132	1	72	sigmoid	sigmoid	HCC1806 WYE-132 0 1 72	8	2.790	0.603	0.466	0.292	0.0448	0.45	0.883	0.997	3.72e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC1806	WYE-125132	2	72	sigmoid	sigmoid	HCC1806 WYE-132 0 2 72	8	2.874	0.872	0.479	0.284	0.045	0.464	0.883	0.997	3.66e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC1806	WYE-125132	3	72	sigmoid	sigmoid	HCC1806 WYE-132 0 3 72	8	3.242	Inf	0.531	0.255	0.0458	0.517	0.885	0.997	3.48e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC1806	XL147	1	72	flat	flat	HCC1806 pilaralisib 0 1 72	8	2.732	Inf	1.02	0.00101	0.0	1.02	0.01	-4.53e-06	1.0	1.0	Inf	1.03	0.999	0.0	1.03	0.01	-0.000107	1.0	1.0
HCC1806	XL147	2	72	flat	flat	HCC1806 pilaralisib 0 2 72	8	2.817	Inf	1.02	0.000975	0.0	1.02	0.01	-4.46e-06	1.0	1.0	Inf	1.03	0.999	0.0	1.03	0.01	-0.000109	1.0	1.0
HCC1806	XL147	3	72	flat	flat	HCC1806 pilaralisib 0 3 72	8	3.185	Inf	1.02	0.000871	0.0	1.02	0.01	-2.12e-06	1.0	1.0	Inf	1.03	0.999	0.0	1.03	0.01	-0.000107	1.0	1.0
HCC1806	ZSTK474	1	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 1 72	8	2.709	Inf	0.602	0.037	1.17	0.599	4.88	0.99	1.12e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
HCC1806	ZSTK474	2	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 2 72	8	2.794	Inf	0.613	0.036	1.16	0.61	5.0	0.99	1.1e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
HCC1806	ZSTK474	3	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 3 72	8	3.162	Inf	0.654	0.0322	1.18	0.65	4.68	0.99	1.03e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
Hs 578T	AS605240	1		sigmoid	sigmoid	Hs578T AS-605240 1	8	2.015	0.758	0.341	0.212	0.333	0.265	0.921	0.991	7.83e-07	NA	1.42	0.447	0.811	0.246	0.408	0.964	0.989	1.51e-06	NA
Hs 578T	AS605240	2		sigmoid	sigmoid	Hs578T AS-605240 2	8	2.547	1.89	0.43	0.194	1.81	0.011	0.541	0.988	1.81e-06	NA	1.6	0.426	0.784	0.971	0.117	0.532	0.983	4.67e-06	NA
Hs 578T	AS605240	3		sigmoid	sigmoid	Hs578T AS-605240 3	8	2.856	63.8	0.588	0.0965	0.826	0.494	1.03	0.983	4.89e-06	NA	5.75	0.518	0.879	0.552	0.465	1.14	0.981	6.87e-06	NA
Hs 578T	AZD-6482	1		sigmoid	sigmoid	Hs578T AZD6482 1	8	2.041	2.04	0.401	0.177	18.5	-1.0	0.498	0.986	2.92e-06	NA	3.16	0.484	0.835	3.16	0.0	0.532	0.98	7.93e-06	NA
Hs 578T	AZD-6482	2		sigmoid	sigmoid	Hs578T AZD6482 2	8	2.508	6.35	0.602	0.121	74.8	-1.0	0.445	0.998	1.12e-08	NA	6.4	0.573	0.86	6.4	0.0	0.475	0.996	6.36e-08	NA
Hs 578T	AZD-6482	3		sigmoid	sigmoid	Hs578T AZD6482 3	8	2.832	6.09	0.667	0.0547	24.1	-1.0	0.799	0.989	1.5e-06	NA	5.12	0.597	0.93	5.12	0.0	0.861	0.985	3.33e-06	NA
Hs 578T	AZD8055	1		sigmoid	sigmoid	Hs578T AZD8055 1	8	2.009	0.0391	0.073	0.531	0.0347	0.0546	0.975	0.995	1.39e-07	NA	0.0591	0.286	0.565	0.0259	0.27	0.941	0.994	1.73e-07	NA
Hs 578T	AZD8055	2		sigmoid	sigmoid	Hs578T AZD8055 2	8	2.480	0.0521	0.149	0.469	0.0387	0.142	1.13	0.999	3.49e-10	NA	0.0495	0.253	0.557	0.0273	0.249	1.16	0.999	4.45e-10	NA
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
Hs 578T	Dactolisib	1		sigmoid	sigmoid	Hs578T dactolisib 1	8	2.047	0.00952	-0.0606	0.691	0.00928	0.0117	0.91	0.977	1.27e-05	NA	0.0124	0.213	0.443	0.00621	0.259	1.06	0.985	3.61e-06	NA
Hs 578T	Dactolisib	2		sigmoid	sigmoid	Hs578T dactolisib 2	8	2.509	0.0128	-0.0617	0.655	0.0126	0.00741	0.79	0.974	1.78e-05	NA	0.0105	0.15	0.405	0.00638	0.203	1.04	0.985	3.67e-06	NA
Hs 578T	Dactolisib	3		sigmoid	sigmoid	Hs578T dactolisib 3	8	2.837	0.0118	0.0569	0.624	0.00848	0.115	0.799	0.96	6.53e-05	NA	0.00728	0.164	0.377	0.0043	0.212	1.05	0.968	3.34e-05	NA
Hs 578T	Buparlisib	1		sigmoid	sigmoid	Hs578T buparlisib 1	8	2.064	0.55	-0.579	0.308	1.29	-1.0	1.29	0.992	4.22e-07	NA	0.587	0.0401	0.759	0.587	0.0	1.31	0.988	1.94e-06	NA
Hs 578T	Buparlisib	2		sigmoid	sigmoid	Hs578T buparlisib 2	8	2.513	0.665	-0.42	0.251	1.61	-1.0	1.24	0.998	1.14e-08	NA	0.595	0.0445	0.779	0.595	0.0	1.36	0.994	2.48e-07	NA
Hs 578T	Buparlisib	3		sigmoid	sigmoid	Hs578T buparlisib 3	8	2.890	0.778	-0.425	0.233	1.71	-1.0	1.4	0.998	1.34e-08	NA	0.622	0.0272	0.779	0.622	0.0	1.57	0.991	8.01e-07	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)