Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	AZD-6482	1	72	sigmoid	sigmoid	BT549 AZD6482 0 1 72	8	1.798	27.5	0.671	0.115	4.1	0.299	0.478	0.992	4.23e-07	NA	164.0	0.723	0.901	4.18	0.408	0.461	0.992	5.34e-07	NA
BT-549	AZD-6482	2	72	sigmoid	sigmoid	BT549 AZD6482 0 2 72	8	1.973	9.15	0.635	0.112	120.0	-1.0	0.426	0.951	0.000115	NA	19.4	0.672	0.895	19.4	0.0	0.437	0.946	0.000154	NA
BT-549	AZD-6482	3	72	sigmoid	sigmoid	BT549 AZD6482 0 3 72	8	1.744	8.87	0.616	0.0979	2.2	0.324	0.749	0.993	2.93e-07	NA	115.0	0.69	0.918	1.91	0.476	0.744	0.993	4.19e-07	NA
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
BT-549	AZD8055	2	72	sigmoid	sigmoid	BT549 AZD8055 0 2 72	8	1.848	0.0373	0.14	0.506	0.0287	0.138	1.23	0.994	2.1e-07	NA	0.0653	0.354	0.605	0.0239	0.35	1.2	0.995	1.39e-07	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
BT-549	Dactolisib	1	72	sigmoid	sigmoid	BT549 dactolisib 0 1 72	8	1.840	0.00961	-0.00769	0.683	0.00888	0.0384	1.01	0.985	3.53e-06	NA	0.0161	0.275	0.482	0.0068	0.303	1.09	0.987	2.38e-06	NA
BT-549	Dactolisib	2	72	sigmoid	sigmoid	BT549 dactolisib 0 2 72	8	1.889	0.00968	-0.00862	0.677	0.00884	0.0542	1.27	0.985	3.3e-06	NA	0.0134	0.266	0.48	0.00701	0.305	1.45	0.988	1.53e-06	NA
BT-549	Dactolisib	3	72	sigmoid	sigmoid	BT549 dactolisib 0 3 72	8	1.801	0.0058	-0.00929	0.751	0.00579	0.000747	0.866	0.994	2.41e-07	NA	0.011	0.282	0.442	0.00425	0.29	0.909	0.995	1.54e-07	NA
BT-549	Buparlisib	1	72	sigmoid	sigmoid	BT549 buparlisib 0 1 72	8	1.837	0.729	-0.325	0.253	1.83	-1.0	1.19	0.994	2.4e-07	NA	0.926	0.136	0.807	0.926	0.0	1.37	0.987	2.46e-06	NA
BT-549	Buparlisib	2	72	sigmoid	sigmoid	BT549 buparlisib 0 2 72	8	1.913	0.681	-0.306	0.217	1.08	-0.538	1.59	0.998	1.31e-08	NA	0.821	0.132	0.838	0.769	0.0514	1.66	0.996	8.95e-08	NA
BT-549	Buparlisib	3	72	sigmoid	sigmoid	BT549 buparlisib 0 3 72	8	1.795	0.602	-0.351	0.295	1.64	-1.0	1.09	0.983	4.52e-06	NA	0.804	0.132	0.777	0.804	0.0	1.26	0.968	3.41e-05	NA
BT-549	BX-912	1	72	sigmoid	sigmoid	BT549 BX-912 0 1 72	8	1.839	0.909	0.247	0.157	0.742	0.24	3.23	0.992	5.95e-07	NA	1.2	0.419	0.872	0.698	0.415	3.25	0.988	1.54e-06	NA
BT-549	BX-912	2	72	sigmoid	sigmoid	BT549 BX-912 0 2 72	8	1.948	1.04	0.33	0.126	0.84	0.329	5.0	0.99	1.01e-06	NA	1.28	0.452	0.892	0.808	0.451	5.0	0.987	2.4e-06	NA
BT-549	BX-912	3	72	sigmoid	sigmoid	BT549 BX-912 0 3 72	8	1.728	1.0	0.335	0.109	0.758	0.332	3.91	0.993	2.87e-07	NA	2.46	0.497	0.916	0.73	0.496	3.92	0.992	6.03e-07	NA
BT-549	Alpelisib	1	72	flat	flat	BT549 alpelisib 0 1 72	8	1.822	Inf	0.747	0.0781	0.0	0.747	0.01	0.439	0.176	0.914	Inf	0.782	0.931	0.0	0.782	0.01	0.415	0.2	0.925
BT-549	Alpelisib	2	72	sigmoid	sigmoid	BT549 alpelisib 0 2 72	8	1.927	Inf	0.832	0.0409	4.24	0.663	0.548	0.706	0.0254	NA	Inf	0.844	0.962	4.26	0.686	0.542	0.696	0.0282	NA
BT-549	Alpelisib	3	72	flat	flat	BT549 alpelisib 0 3 72	8	1.743	Inf	0.817	0.068	0.0	0.817	0.01	-0.0192	1.0	0.915	Inf	0.846	0.942	0.0	0.846	0.01	-0.0162	1.0	0.928
BT-549	CAL-101	1	72	sigmoid	sigmoid	BT549 idelalisib 0 1 72	8	1.791	Inf	0.836	0.041	4.8	0.605	0.778	0.924	0.00044	NA	Inf	0.858	0.964	4.79	0.659	0.767	0.92	0.000518	NA
BT-549	CAL-101	2	72	sigmoid	sigmoid	BT549 idelalisib 0 2 72	8	1.975	Inf	0.792	0.0561	4.65	0.526	0.693	0.933	0.000307	NA	43.0	0.805	0.946	43.0	0.0	0.548	0.932	0.000314	NA
BT-549	CAL-101	3	72	sigmoid	sigmoid	BT549 idelalisib 0 3 72	8	1.770	43.0	0.79	0.0687	320.0	-0.664	0.421	0.862	0.00261	NA	118.0	0.822	0.941	118.0	0.0	0.425	0.854	0.00309	NA
BT-549	Everolimus	1	72	sigmoid	sigmoid	BT549 everolimus 0 1 72	8	1.772	5.64	0.503	0.444	1e-05	0.367	0.1	0.911	0.000706	NA	437200.0	0.603	0.641	0.000146	0.444	0.1	0.858	0.00286	NA
BT-549	Everolimus	2	72	flat	flat	BT549 everolimus 0 2 72	8	1.909	Inf	0.566	0.407	0.0	0.566	0.01	-0.646	1.0	0.594	Inf	0.627	0.648	0.0	0.627	0.01	-1.01	1.0	0.649
BT-549	Everolimus	3	72	sigmoid	flat	BT549 everolimus 0 3 72	8	1.587	59.5	0.533	0.425	1e-05	0.395	0.1	0.702	0.0264	NA	Inf	0.656	0.685	0.0	0.656	0.01	0.48	0.141	0.685
BT-549	Pictilisib	1	72	sigmoid	sigmoid	BT549 pictilisib 0 1 72	8	1.772	2.08	0.415	0.117	1.42	0.154	0.959	0.987	2.26e-06	NA	5.12	0.541	0.904	1.06	0.396	0.995	0.985	3.49e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)