Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | AZD8055 | 1 | 72 | 0.32 | 5696.0 | 11579.3 | 1742.8 | -0.495 | 0.543 | 0.492 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 1.0 | 5727.5 | 11579.3 | 1742.8 | 0.0 | 0.546 | 0.495 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 3.2 | 5607.0 | 11579.3 | 1742.8 | 0.505 | 0.534 | 0.484 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.001 | 11630.8 | 11670.0 | 1742.8 | -3.0 | 0.998 | 0.997 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.0032 | 10570.3 | 11670.0 | 1742.8 | -2.49 | 0.929 | 0.906 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.01 | 9243.3 | 11670.0 | 1742.8 | -2.0 | 0.837 | 0.792 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.032 | 7096.0 | 11670.0 | 1742.8 | -1.49 | 0.668 | 0.608 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.1 | 6060.8 | 11670.0 | 1742.8 | -1.0 | 0.575 | 0.519 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.32 | 4335.3 | 11670.0 | 1742.8 | -0.495 | 0.394 | 0.371 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 1.0 | 1879.0 | 11670.0 | 1742.8 | 0.0 | 0.028 | 0.161 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 3.2 | 1409.8 | 11670.0 | 1742.8 | 0.505 | -0.074 | 0.121 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.001 | 11516.0 | 11660.8 | 1742.8 | -3.0 | 0.991 | 0.988 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.0032 | 11494.8 | 11660.8 | 1742.8 | -2.49 | 0.990 | 0.986 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.01 | 11603.0 | 11660.8 | 1742.8 | -2.0 | 0.996 | 0.995 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.032 | 11523.5 | 11660.8 | 1742.8 | -1.49 | 0.991 | 0.988 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.1 | 11343.3 | 11660.8 | 1742.8 | -1.0 | 0.980 | 0.973 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 0.32 | 10585.3 | 11660.8 | 1742.8 | -0.495 | 0.931 | 0.908 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 1.0 | 3030.5 | 11660.8 | 1742.8 | 0.0 | 0.224 | 0.260 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 1 | 72 | 3.2 | 493.8 | 11660.8 | 1742.8 | 0.505 | -0.369 | 0.042 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.001 | 11136.3 | 11641.0 | 1742.8 | -3.0 | 0.968 | 0.957 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.0032 | 11758.0 | 11641.0 | 1742.8 | -2.49 | 1.010 | 1.010 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.01 | 11557.5 | 11641.0 | 1742.8 | -2.0 | 0.995 | 0.993 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.032 | 11715.5 | 11641.0 | 1742.8 | -1.49 | 1.000 | 1.010 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.1 | 11604.5 | 11641.0 | 1742.8 | -1.0 | 0.998 | 0.997 | 2.740 | HCC1806 BX912 0 1 72 |
| HCC1806 | BX-912 | 1 | 72 | 0.32 | 11016.8 | 11641.0 | 1742.8 | -0.495 | 0.960 | 0.946 | 2.740 | HCC1806 BX912 0 1 72 |