Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC1806 Pictilisib 2 72
3.2
 8798.5 11984.0 1643.3
0.505
 0.796 0.734 2.866
HCC1806 GDC0941 0 2 72
HCC1806 GDC-0980 2 72
0.001
 11516.0 11293.0 1643.3
-3.0
 1.010 1.020 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
0.0032
 11217.3 11293.0 1643.3
-2.49
 0.995 0.993 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
0.01
 11207.3 11293.0 1643.3
-2.0
 0.995 0.992 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
0.032
 11461.8 11293.0 1643.3
-1.49
 1.010 1.010 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
0.1
 10419.3 11293.0 1643.3
-1.0
 0.943 0.923 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
0.32
 7985.5 11293.0 1643.3
-0.495
 0.766 0.707 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
1.0
 5800.0 11293.0 1643.3
0.0
 0.574 0.514 2.781
HCC1806 GDC0980 0 2 72
HCC1806 GDC-0980 2 72
3.2
 3828.3 11293.0 1643.3
0.505
 0.355 0.339 2.781
HCC1806 GDC0980 0 2 72
HCC1806 Omipalisib 2 72
0.001
 10878.5 11840.0 1643.3
-3.0
 0.941 0.919 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
0.0032
 11552.0 11840.0 1643.3
-2.49
 0.983 0.976 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
0.01
 10689.3 11840.0 1643.3
-2.0
 0.929 0.903 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
0.032
 7012.3 11840.0 1643.3
-1.49
 0.664 0.592 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
0.1
 4476.3 11840.0 1643.3
-1.0
 0.422 0.378 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
0.32
 3470.8 11840.0 1643.3
-0.495
 0.300 0.293 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
1.0
 1813.3 11840.0 1643.3
0.0
 0.035 0.153 2.849
HCC1806 GSK458 0 2 72
HCC1806 Omipalisib 2 72
3.2
 569.3 11840.0 1643.3
0.505
 -0.311 0.048 2.849
HCC1806 GSK458 0 2 72
HCC1806 KIN001-244 2 72
0.001
 11912.3 11660.3 1643.3
-3.0
 1.020 1.020 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
0.0032
 11082.0 11660.3 1643.3
-2.49
 0.964 0.950 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
0.01
 10733.5 11660.3 1643.3
-2.0
 0.942 0.921 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
0.032
 10972.3 11660.3 1643.3
-1.49
 0.957 0.941 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
0.1
 11622.0 11660.3 1643.3
-1.0
 0.998 0.997 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
0.32
 11461.0 11660.3 1643.3
-0.495
 0.988 0.983 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
1.0
 11475.5 11660.3 1643.3
0.0
 0.989 0.984 2.827
HCC1806 KIN001-244 0 2 72
HCC1806 KIN001-244 2 72
3.2
 11439.0 11660.3 1643.3
0.505
 0.986 0.981 2.827
HCC1806 KIN001-244 0 2 72