Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 AZD-6482 2 72
0.001
 2737.3 3186.5 1018.6
-3.0
 0.824 0.859 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
0.0032
 2774.5 3186.5 1018.6
-2.49
 0.839 0.871 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
0.01
 2863.5 3186.5 1018.6
-2.0
 0.874 0.899 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
0.032
 2798.3 3186.5 1018.6
-1.49
 0.848 0.878 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
0.1
 2717.8 3186.5 1018.6
-1.0
 0.816 0.853 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
0.32
 2528.8 3186.5 1018.6
-0.495
 0.738 0.794 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
1.0
 1651.0 3186.5 1018.6
0.0
 0.341 0.518 1.645
BT20 AZD6482 0 2
BT-20 AZD-6482 2 72
3.2
 1061.3 3186.5 1018.6
0.505
 0.025 0.333 1.645
BT20 AZD6482 0 2
BT-20 AZD8055 2 72
0.001
 3041.5 3421.5 1018.6
-3.0
 0.870 0.889 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
0.0032
 2842.0 3421.5 1018.6
-2.49
 0.799 0.831 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
0.01
 2548.3 3421.5 1018.6
-2.0
 0.690 0.745 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
0.032
 1518.3 3421.5 1018.6
-1.49
 0.257 0.444 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
0.1
 929.8 3421.5 1018.6
-1.0
 -0.051 0.272 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
0.32
 674.3 3421.5 1018.6
-0.495
 -0.210 0.197 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
1.0
 575.0 3421.5 1018.6
0.0
 -0.279 0.168 1.748
BT20 AZD8055 0 2
BT-20 AZD8055 2 72
3.2
 419.0 3421.5 1018.6
0.505
 -0.398 0.122 1.748
BT20 AZD8055 0 2
BT-20 Dactolisib 2 72
0.001
 2934.3 3372.5 1018.6
-3.0
 0.845 0.870 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
0.0032
 2500.5 3372.5 1018.6
-2.49
 0.682 0.741 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
0.01
 1451.8 3372.5 1018.6
-2.0
 0.228 0.430 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
0.032
 1014.0 3372.5 1018.6
-1.49
 -0.003 0.301 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
0.1
 764.5 3372.5 1018.6
-1.0
 -0.153 0.227 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
0.32
 767.8 3372.5 1018.6
-0.495
 -0.151 0.228 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
1.0
 675.5 3372.5 1018.6
0.0
 -0.212 0.200 1.727
BT20 BEZ235 0 2
BT-20 Dactolisib 2 72
3.2
 731.3 3372.5 1018.6
0.505
 -0.175 0.217 1.727
BT20 BEZ235 0 2
BT-20 Buparlisib 2 72
0.001
 2951.5 3408.8 1018.6
-3.0
 0.841 0.866 1.743
BT20 BKM120 0 2