Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Pictilisib | 1 | 72 | 0.001 | 3315.0 | 3399.0 | 1279.8 | -3.0 | 0.965 | 0.975 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 0.0032 | 3320.0 | 3399.0 | 1279.8 | -2.49 | 0.967 | 0.977 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 0.01 | 3450.5 | 3399.0 | 1279.8 | -2.0 | 1.020 | 1.020 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 0.032 | 3286.3 | 3399.0 | 1279.8 | -1.49 | 0.953 | 0.967 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 0.1 | 3111.8 | 3399.0 | 1279.8 | -1.0 | 0.879 | 0.915 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 0.32 | 2373.8 | 3399.0 | 1279.8 | -0.495 | 0.550 | 0.698 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 1.0 | 1671.8 | 3399.0 | 1279.8 | 0.0 | 0.209 | 0.492 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | Pictilisib | 1 | 72 | 3.2 | 1105.0 | 3399.0 | 1279.8 | 0.505 | -0.099 | 0.325 | 1.409 | HCC70 GDC0941 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.001 | 3278.5 | 3261.8 | 1279.8 | -3.0 | 1.010 | 1.010 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.0032 | 3463.3 | 3261.8 | 1279.8 | -2.49 | 1.090 | 1.060 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.01 | 3329.8 | 3261.8 | 1279.8 | -2.0 | 1.030 | 1.020 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.032 | 3182.3 | 3261.8 | 1279.8 | -1.49 | 0.964 | 0.976 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.1 | 2676.5 | 3261.8 | 1279.8 | -1.0 | 0.727 | 0.821 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 0.32 | 1777.3 | 3261.8 | 1279.8 | -0.495 | 0.275 | 0.545 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 1.0 | 1338.5 | 3261.8 | 1279.8 | 0.0 | 0.034 | 0.410 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | GDC-0980 | 1 | 72 | 3.2 | 772.8 | 3261.8 | 1279.8 | 0.505 | -0.312 | 0.237 | 1.350 | HCC70 GDC0980 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.001 | 2646.0 | 3280.0 | 1279.8 | -3.0 | 0.707 | 0.807 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.0032 | 2642.3 | 3280.0 | 1279.8 | -2.49 | 0.706 | 0.806 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.01 | 1823.5 | 3280.0 | 1279.8 | -2.0 | 0.298 | 0.556 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.032 | 968.5 | 3280.0 | 1279.8 | -1.49 | -0.186 | 0.295 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.1 | 538.5 | 3280.0 | 1279.8 | -1.0 | -0.471 | 0.164 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.32 | 383.8 | 3280.0 | 1279.8 | -0.495 | -0.588 | 0.117 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 1.0 | 253.0 | 3280.0 | 1279.8 | 0.0 | -0.697 | 0.077 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 3.2 | 159.3 | 3280.0 | 1279.8 | 0.505 | -0.785 | 0.049 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 0.001 | 3292.8 | 3263.0 | 1279.8 | -3.0 | 1.010 | 1.010 | 1.350 | HCC70 KIN001-244 0 1 72 |