Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | Pictilisib | 1 | 72 | 0.01 | 5399.3 | 5311.0 | 1554.9 | -2.0 | 1.020 | 1.020 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 0.032 | 5324.8 | 5311.0 | 1554.9 | -1.49 | 1.000 | 1.000 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 0.1 | 5050.5 | 5311.0 | 1554.9 | -1.0 | 0.944 | 0.951 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 0.32 | 4418.3 | 5311.0 | 1554.9 | -0.495 | 0.803 | 0.832 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 1.0 | 3848.0 | 5311.0 | 1554.9 | 0.0 | 0.667 | 0.725 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 3.2 | 2875.3 | 5311.0 | 1554.9 | 0.505 | 0.415 | 0.541 | 1.772 | BT549 GDC0941 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.001 | 5336.8 | 5343.8 | 1554.9 | -3.0 | 0.999 | 0.999 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.0032 | 5411.8 | 5343.8 | 1554.9 | -2.49 | 1.010 | 1.010 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.01 | 5203.0 | 5343.8 | 1554.9 | -2.0 | 0.970 | 0.974 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.032 | 4908.8 | 5343.8 | 1554.9 | -1.49 | 0.907 | 0.919 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.1 | 3880.3 | 5343.8 | 1554.9 | -1.0 | 0.671 | 0.726 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 0.32 | 2708.3 | 5343.8 | 1554.9 | -0.495 | 0.366 | 0.507 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 1.0 | 2114.8 | 5343.8 | 1554.9 | 0.0 | 0.188 | 0.396 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 3.2 | 1881.0 | 5343.8 | 1554.9 | 0.505 | 0.113 | 0.352 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.001 | 5198.0 | 5372.5 | 1554.9 | -3.0 | 0.963 | 0.968 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.0032 | 4586.5 | 5372.5 | 1554.9 | -2.49 | 0.831 | 0.854 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.01 | 3789.0 | 5372.5 | 1554.9 | -2.0 | 0.645 | 0.705 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.032 | 2334.0 | 5372.5 | 1554.9 | -1.49 | 0.255 | 0.434 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.1 | 1881.0 | 5372.5 | 1554.9 | -1.0 | 0.112 | 0.350 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 0.32 | 1638.5 | 5372.5 | 1554.9 | -0.495 | 0.030 | 0.305 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 1.0 | 1268.8 | 5372.5 | 1554.9 | 0.0 | -0.107 | 0.236 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | Omipalisib | 1 | 72 | 3.2 | 1043.3 | 5372.5 | 1554.9 | 0.505 | -0.200 | 0.194 | 1.789 | BT549 GSK458 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 0.001 | 5580.0 | 5422.3 | 1554.9 | -3.0 | 1.030 | 1.030 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 0.0032 | 5282.0 | 5422.3 | 1554.9 | -2.49 | 0.971 | 0.974 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 0.01 | 5363.0 | 5422.3 | 1554.9 | -2.0 | 0.988 | 0.989 | 1.802 | BT549 KIN001-244 0 1 72 |