Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | AZD-6482 | 3 | 72 | 0.032 | 4133.5 | 4067.8 | 571.3 | -1.49 | 1.010 | 1.020 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 0.1 | 3872.5 | 4067.8 | 571.3 | -1.0 | 0.966 | 0.952 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 0.32 | 3662.3 | 4067.8 | 571.3 | -0.495 | 0.927 | 0.900 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 1.0 | 3315.0 | 4067.8 | 571.3 | 0.0 | 0.861 | 0.815 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD-6482 | 3 | 72 | 3.2 | 2428.5 | 4067.8 | 571.3 | 0.505 | 0.667 | 0.597 | 2.832 | Hs578T AZD6482 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.001 | 3907.0 | 4224.8 | 571.3 | -3.0 | 0.947 | 0.925 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.0032 | 3743.8 | 4224.8 | 571.3 | -2.49 | 0.918 | 0.886 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.01 | 3228.5 | 4224.8 | 571.3 | -2.0 | 0.822 | 0.764 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.032 | 2320.3 | 4224.8 | 571.3 | -1.49 | 0.625 | 0.549 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.1 | 1460.5 | 4224.8 | 571.3 | -1.0 | 0.384 | 0.346 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.32 | 1113.3 | 4224.8 | 571.3 | -0.495 | 0.260 | 0.264 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 1.0 | 1042.3 | 4224.8 | 571.3 | 0.0 | 0.232 | 0.247 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 3.2 | 1096.0 | 4224.8 | 571.3 | 0.505 | 0.253 | 0.259 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.001 | 3761.0 | 4081.0 | 571.3 | -3.0 | 0.943 | 0.922 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.0032 | 2463.0 | 4081.0 | 571.3 | -2.49 | 0.674 | 0.604 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.01 | 1908.8 | 4081.0 | 571.3 | -2.0 | 0.530 | 0.468 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.032 | 1181.8 | 4081.0 | 571.3 | -1.49 | 0.292 | 0.290 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.1 | 1169.3 | 4081.0 | 571.3 | -1.0 | 0.287 | 0.287 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 0.32 | 1044.0 | 4081.0 | 571.3 | -0.495 | 0.237 | 0.256 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 1.0 | 774.3 | 4081.0 | 571.3 | 0.0 | 0.113 | 0.190 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Dactolisib | 3 | 72 | 3.2 | 668.5 | 4081.0 | 571.3 | 0.505 | 0.057 | 0.164 | 2.837 | Hs578T BEZ235 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.001 | 4118.3 | 4235.0 | 571.3 | -3.0 | 0.981 | 0.972 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.0032 | 3993.3 | 4235.0 | 571.3 | -2.49 | 0.960 | 0.943 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.01 | 4384.3 | 4235.0 | 571.3 | -2.0 | 1.020 | 1.040 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.032 | 4168.0 | 4235.0 | 571.3 | -1.49 | 0.989 | 0.984 | 2.890 | Hs578T BKM120 3 |