Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T XL147 2 72
0.01
 3614.3 3556.8 624.7
-2.0
 1.010 1.020 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
0.032
 3605.5 3556.8 624.7
-1.49
 1.010 1.010 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
0.1
 3594.0 3556.8 624.7
-1.0
 1.010 1.010 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
0.32
 3631.0 3556.8 624.7
-0.495
 1.020 1.020 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
1.0
 3462.3 3556.8 624.7
0.0
 0.979 0.973 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
3.2
 3449.5 3556.8 624.7
0.505
 0.976 0.970 2.509
Hs578T XL147 2
Hs 578T ZSTK474 2 72
0.001
 3461.3 3668.0 624.7
-3.0
 0.955 0.944 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
0.0032
 3474.8 3668.0 624.7
-2.49
 0.958 0.947 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
0.01
 3360.0 3668.0 624.7
-2.0
 0.932 0.916 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
0.032
 3160.0 3668.0 624.7
-1.49
 0.887 0.862 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
0.1
 2555.5 3668.0 624.7
-1.0
 0.736 0.697 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
0.32
 2154.3 3668.0 624.7
-0.495
 0.624 0.587 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
1.0
 1628.5 3668.0 624.7
0.0
 0.455 0.444 2.554
Hs578T ZSTK474 2
Hs 578T ZSTK474 2 72
3.2
 968.8 3668.0 624.7
0.505
 0.187 0.264 2.554
Hs578T ZSTK474 2
Hs 578T AS605240 3 72
0.001
 4217.0 4137.8 571.3
-3.0
 1.010 1.020 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
0.0032
 4043.3 4137.8 571.3
-2.49
 0.984 0.977 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
0.01
 4110.5 4137.8 571.3
-2.0
 0.995 0.993 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
0.032
 4174.0 4137.8 571.3
-1.49
 1.010 1.010 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
0.1
 3949.0 4137.8 571.3
-1.0
 0.968 0.954 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
0.32
 3202.5 4137.8 571.3
-0.495
 0.828 0.774 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
1.0
 2795.3 4137.8 571.3
0.0
 0.743 0.676 2.856
Hs578T AS605240 3
Hs 578T AS605240 3 72
3.2
 2141.8 4137.8 571.3
0.505
 0.588 0.518 2.856
Hs578T AS605240 3
Hs 578T AZD-6482 3 72
0.001
 4052.5 4067.8 571.3
-3.0
 0.997 0.996 2.832
Hs578T AZD6482 3
Hs 578T AZD-6482 3 72
0.0032
 4163.3 4067.8 571.3
-2.49
 1.020 1.020 2.832
Hs578T AZD6482 3
Hs 578T AZD-6482 3 72
0.01
 4098.3 4067.8 571.3
-2.0
 1.010 1.010 2.832
Hs578T AZD6482 3