Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | PI103 | 3 | 72 | 0.001 | 10973.0 | 11113.3 | 1273.3 | -3.0 | 0.992 | 0.987 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.0032 | 11168.3 | 11113.3 | 1273.3 | -2.49 | 1.000 | 1.000 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.01 | 11663.8 | 11113.3 | 1273.3 | -2.0 | 1.030 | 1.050 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.032 | 11750.3 | 11113.3 | 1273.3 | -1.49 | 1.040 | 1.060 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.1 | 10951.8 | 11113.3 | 1273.3 | -1.0 | 0.991 | 0.985 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 0.32 | 10874.3 | 11113.3 | 1273.3 | -0.495 | 0.986 | 0.978 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 1.0 | 10453.3 | 11113.3 | 1273.3 | 0.0 | 0.961 | 0.941 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PI103 | 3 | 72 | 3.2 | 9624.3 | 11113.3 | 1273.3 | 0.505 | 0.910 | 0.866 | 3.126 | HCC1806 PI103 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.001 | 11663.0 | 11752.8 | 1273.3 | -3.0 | 0.995 | 0.992 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.0032 | 11204.3 | 11752.8 | 1273.3 | -2.49 | 0.970 | 0.953 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.01 | 11234.5 | 11752.8 | 1273.3 | -2.0 | 0.972 | 0.956 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.032 | 11478.5 | 11752.8 | 1273.3 | -1.49 | 0.985 | 0.977 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.1 | 11468.5 | 11752.8 | 1273.3 | -1.0 | 0.985 | 0.976 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 0.32 | 11233.8 | 11752.8 | 1273.3 | -0.495 | 0.972 | 0.956 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 1.0 | 10760.3 | 11752.8 | 1273.3 | 0.0 | 0.946 | 0.916 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | PIK-93 | 3 | 72 | 3.2 | 9528.0 | 11752.8 | 1273.3 | 0.505 | 0.873 | 0.811 | 3.206 | HCC1806 PIK93 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.001 | 9616.0 | 12104.5 | 1273.3 | -3.0 | 0.863 | 0.794 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.0032 | 9333.0 | 12104.5 | 1273.3 | -2.49 | 0.846 | 0.771 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.01 | 9275.5 | 12104.5 | 1273.3 | -2.0 | 0.843 | 0.766 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.032 | 9181.8 | 12104.5 | 1273.3 | -1.49 | 0.837 | 0.759 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.1 | 9292.5 | 12104.5 | 1273.3 | -1.0 | 0.844 | 0.768 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.32 | 8965.0 | 12104.5 | 1273.3 | -0.495 | 0.823 | 0.741 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 1.0 | 9238.3 | 12104.5 | 1273.3 | 0.0 | 0.840 | 0.763 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 3.2 | 8674.0 | 12104.5 | 1273.3 | 0.505 | 0.805 | 0.717 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | TGX221 | 3 | 72 | 0.001 | 11092.3 | 11158.5 | 1273.3 | -3.0 | 0.996 | 0.994 | 3.132 | HCC1806 TGX221 0 3 72 |