Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | GDC-0980 | 3 | 72 | 3.2 | 3828.3 | 11293.0 | 1273.3 | 0.505 | 0.418 | 0.339 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.001 | 10878.5 | 11840.0 | 1273.3 | -3.0 | 0.948 | 0.919 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.0032 | 11552.0 | 11840.0 | 1273.3 | -2.49 | 0.985 | 0.976 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.01 | 10689.3 | 11840.0 | 1273.3 | -2.0 | 0.937 | 0.903 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.032 | 7012.3 | 11840.0 | 1273.3 | -1.49 | 0.699 | 0.592 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.1 | 4476.3 | 11840.0 | 1273.3 | -1.0 | 0.478 | 0.378 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.32 | 3470.8 | 11840.0 | 1273.3 | -0.495 | 0.366 | 0.293 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 1.0 | 1813.3 | 11840.0 | 1273.3 | 0.0 | 0.116 | 0.153 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 3 | 72 | 3.2 | 569.3 | 11840.0 | 1273.3 | 0.505 | -0.221 | 0.048 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.001 | 11912.3 | 11660.3 | 1273.3 | -3.0 | 1.010 | 1.020 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.0032 | 11082.0 | 11660.3 | 1273.3 | -2.49 | 0.968 | 0.950 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.01 | 10733.5 | 11660.3 | 1273.3 | -2.0 | 0.949 | 0.921 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.032 | 10972.3 | 11660.3 | 1273.3 | -1.49 | 0.962 | 0.941 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.1 | 11622.0 | 11660.3 | 1273.3 | -1.0 | 0.998 | 0.997 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.32 | 11461.0 | 11660.3 | 1273.3 | -0.495 | 0.989 | 0.983 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 1.0 | 11475.5 | 11660.3 | 1273.3 | 0.0 | 0.990 | 0.984 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 3.2 | 11439.0 | 11660.3 | 1273.3 | 0.505 | 0.988 | 0.981 | 3.195 | HCC1806 KIN001-244 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.001 | 11458.3 | 11692.5 | 1273.3 | -3.0 | 0.987 | 0.980 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.0032 | 11472.3 | 11692.5 | 1273.3 | -2.49 | 0.988 | 0.981 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.01 | 11541.0 | 11692.5 | 1273.3 | -2.0 | 0.992 | 0.987 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.032 | 11428.3 | 11692.5 | 1273.3 | -1.49 | 0.986 | 0.977 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.1 | 11113.3 | 11692.5 | 1273.3 | -1.0 | 0.968 | 0.950 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 0.32 | 10467.5 | 11692.5 | 1273.3 | -0.495 | 0.932 | 0.895 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 1.0 | 10180.5 | 11692.5 | 1273.3 | 0.0 | 0.915 | 0.871 | 3.199 | HCC1806 MK2206 0 3 72 |
| HCC1806 | MK2206 | 3 | 72 | 3.2 | 8994.8 | 11692.5 | 1273.3 | 0.505 | 0.843 | 0.769 | 3.199 | HCC1806 MK2206 0 3 72 |