Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin1 | 1 | 72 | 1.0 | 1708.3 | 5863.3 | 1443.3 | 0.0 | 0.087 | 0.291 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | Torin1 | 1 | 72 | 3.2 | 1153.3 | 5863.3 | 1443.3 | 0.505 | -0.105 | 0.197 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.001 | 5188.5 | 5846.0 | 1443.3 | -3.0 | 0.885 | 0.888 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.0032 | 4781.5 | 5846.0 | 1443.3 | -2.49 | 0.810 | 0.818 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.01 | 3473.5 | 5846.0 | 1443.3 | -2.0 | 0.545 | 0.594 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.032 | 2533.0 | 5846.0 | 1443.3 | -1.49 | 0.321 | 0.433 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.1 | 1832.3 | 5846.0 | 1443.3 | -1.0 | 0.126 | 0.313 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.32 | 1264.3 | 5846.0 | 1443.3 | -0.495 | -0.064 | 0.216 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 1.0 | 457.3 | 5846.0 | 1443.3 | 0.0 | -0.434 | 0.078 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Torin2 | 1 | 72 | 3.2 | 96.0 | 5846.0 | 1443.3 | 0.505 | -0.739 | 0.016 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.001 | 5603.8 | 5837.3 | 1443.3 | -3.0 | 0.960 | 0.960 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.0032 | 5464.0 | 5837.3 | 1443.3 | -2.49 | 0.936 | 0.936 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.01 | 5356.8 | 5837.3 | 1443.3 | -2.0 | 0.917 | 0.918 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.032 | 4760.5 | 5837.3 | 1443.3 | -1.49 | 0.808 | 0.816 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.1 | 4383.3 | 5837.3 | 1443.3 | -1.0 | 0.735 | 0.751 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.32 | 4169.8 | 5837.3 | 1443.3 | -0.495 | 0.693 | 0.714 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 1.0 | 3683.0 | 5837.3 | 1443.3 | 0.0 | 0.592 | 0.631 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | Trametinib | 1 | 72 | 3.2 | 3445.8 | 5837.3 | 1443.3 | 0.505 | 0.540 | 0.590 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.001 | 5623.5 | 5739.3 | 1443.3 | -3.0 | 0.980 | 0.980 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.0032 | 5504.3 | 5739.3 | 1443.3 | -2.49 | 0.958 | 0.959 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.01 | 5356.0 | 5739.3 | 1443.3 | -2.0 | 0.932 | 0.933 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.032 | 4261.5 | 5739.3 | 1443.3 | -1.49 | 0.722 | 0.743 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.1 | 3326.8 | 5739.3 | 1443.3 | -1.0 | 0.521 | 0.580 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.32 | 2481.3 | 5739.3 | 1443.3 | -0.495 | 0.313 | 0.432 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 1.0 | 2450.3 | 5739.3 | 1443.3 | 0.0 | 0.304 | 0.427 | 1.991 | BT20 WYE125132 0 1 |