Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | WYE-125132 | 1 | 72 | 3.2 | 2287.3 | 5739.3 | 1443.3 | 0.505 | 0.260 | 0.399 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.001 | 5542.8 | 6311.0 | 1443.3 | -3.0 | 0.882 | 0.878 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.0032 | 6093.3 | 6311.0 | 1443.3 | -2.49 | 0.967 | 0.965 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.01 | 6197.3 | 6311.0 | 1443.3 | -2.0 | 0.983 | 0.982 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.032 | 6167.5 | 6311.0 | 1443.3 | -1.49 | 0.979 | 0.977 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.1 | 6140.3 | 6311.0 | 1443.3 | -1.0 | 0.974 | 0.973 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 0.32 | 6290.0 | 6311.0 | 1443.3 | -0.495 | 0.997 | 0.997 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 1.0 | 5762.8 | 6311.0 | 1443.3 | 0.0 | 0.916 | 0.913 | 2.128 | BT20 XL147 0 1 |
| BT-20 | XL147 | 1 | 72 | 3.2 | 5132.5 | 6311.0 | 1443.3 | 0.505 | 0.815 | 0.813 | 2.128 | BT20 XL147 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.001 | 5978.0 | 5537.8 | 1443.3 | -3.0 | 1.080 | 1.080 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.0032 | 5912.0 | 5537.8 | 1443.3 | -2.49 | 1.070 | 1.070 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.01 | 6056.8 | 5537.8 | 1443.3 | -2.0 | 1.090 | 1.090 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.032 | 6289.3 | 5537.8 | 1443.3 | -1.49 | 1.140 | 1.140 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.1 | 6021.3 | 5537.8 | 1443.3 | -1.0 | 1.090 | 1.090 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 0.32 | 4643.0 | 5537.8 | 1443.3 | -0.495 | 0.826 | 0.838 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 1.0 | 2728.0 | 5537.8 | 1443.3 | 0.0 | 0.388 | 0.493 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | ZSTK474 | 1 | 72 | 3.2 | 1504.8 | 5537.8 | 1443.3 | 0.505 | 0.022 | 0.272 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | AS605240 | 2 | 72 | 0.001 | 3107.0 | 3661.0 | 1018.6 | -3.0 | 0.830 | 0.849 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 0.0032 | 3179.8 | 3661.0 | 1018.6 | -2.49 | 0.853 | 0.869 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 0.01 | 3080.3 | 3661.0 | 1018.6 | -2.0 | 0.821 | 0.841 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 0.032 | 3049.3 | 3661.0 | 1018.6 | -1.49 | 0.811 | 0.833 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 0.1 | 2935.5 | 3661.0 | 1018.6 | -1.0 | 0.774 | 0.802 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 0.32 | 3018.5 | 3661.0 | 1018.6 | -0.495 | 0.801 | 0.825 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 1.0 | 2828.3 | 3661.0 | 1018.6 | 0.0 | 0.739 | 0.773 | 1.846 | BT20 AS605240 0 2 |
| BT-20 | AS605240 | 2 | 72 | 3.2 | 2797.5 | 3661.0 | 1018.6 | 0.505 | 0.729 | 0.764 | 1.846 | BT20 AS605240 0 2 |