Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | Trametinib | 3 | 72 | 0.32 | 2643.3 | 3968.8 | 1175.8 | -0.495 | 0.587 | 0.666 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 1.0 | 2549.8 | 3968.8 | 1175.8 | 0.0 | 0.554 | 0.642 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 3.2 | 2546.8 | 3968.8 | 1175.8 | 0.505 | 0.553 | 0.642 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.001 | 3714.5 | 3719.8 | 1175.8 | -3.0 | 0.998 | 0.999 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.0032 | 3325.0 | 3719.8 | 1175.8 | -2.49 | 0.869 | 0.894 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.01 | 3085.5 | 3719.8 | 1175.8 | -2.0 | 0.787 | 0.829 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.032 | 2088.0 | 3719.8 | 1175.8 | -1.49 | 0.413 | 0.561 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.1 | 1703.0 | 3719.8 | 1175.8 | -1.0 | 0.250 | 0.458 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 0.32 | 1378.5 | 3719.8 | 1175.8 | -0.495 | 0.100 | 0.371 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 1.0 | 1367.3 | 3719.8 | 1175.8 | 0.0 | 0.095 | 0.368 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | WYE-125132 | 3 | 72 | 3.2 | 1228.0 | 3719.8 | 1175.8 | 0.505 | 0.027 | 0.330 | 1.662 | BT549 WYE125132 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.001 | 3846.0 | 4015.3 | 1175.8 | -3.0 | 0.952 | 0.958 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.0032 | 3813.5 | 4015.3 | 1175.8 | -2.49 | 0.943 | 0.950 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.01 | 3927.0 | 4015.3 | 1175.8 | -2.0 | 0.975 | 0.978 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.032 | 3899.3 | 4015.3 | 1175.8 | -1.49 | 0.967 | 0.971 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.1 | 3893.8 | 4015.3 | 1175.8 | -1.0 | 0.966 | 0.970 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.32 | 3977.8 | 4015.3 | 1175.8 | -0.495 | 0.989 | 0.991 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 1.0 | 3918.0 | 4015.3 | 1175.8 | 0.0 | 0.973 | 0.976 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 3.2 | 3779.0 | 4015.3 | 1175.8 | 0.505 | 0.933 | 0.941 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.001 | 3958.0 | 4025.8 | 1175.8 | -3.0 | 0.981 | 0.983 | 1.776 | BT549 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.0032 | 3871.0 | 4025.8 | 1175.8 | -2.49 | 0.956 | 0.962 | 1.776 | BT549 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.01 | 3882.8 | 4025.8 | 1175.8 | -2.0 | 0.960 | 0.964 | 1.776 | BT549 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.032 | 3709.5 | 4025.8 | 1175.8 | -1.49 | 0.910 | 0.921 | 1.776 | BT549 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.1 | 3343.0 | 4025.8 | 1175.8 | -1.0 | 0.801 | 0.830 | 1.776 | BT549 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 3 | 72 | 0.32 | 2797.5 | 4025.8 | 1175.8 | -0.495 | 0.629 | 0.695 | 1.776 | BT549 ZSTK474 0 3 72 |