Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TGX221 | 3 | 72 | 0.1 | 3789.3 | 4003.5 | 1175.8 | -1.0 | 0.939 | 0.946 | 1.768 | BT549 TGX221 0 3 72 |
| BT-549 | TGX221 | 3 | 72 | 0.32 | 3556.8 | 4003.5 | 1175.8 | -0.495 | 0.871 | 0.888 | 1.768 | BT549 TGX221 0 3 72 |
| BT-549 | TGX221 | 3 | 72 | 1.0 | 3617.3 | 4003.5 | 1175.8 | 0.0 | 0.888 | 0.904 | 1.768 | BT549 TGX221 0 3 72 |
| BT-549 | TGX221 | 3 | 72 | 3.2 | 3338.0 | 4003.5 | 1175.8 | 0.505 | 0.805 | 0.834 | 1.768 | BT549 TGX221 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.001 | 3776.3 | 3974.5 | 1175.8 | -3.0 | 0.943 | 0.950 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.0032 | 3286.0 | 3974.5 | 1175.8 | -2.49 | 0.795 | 0.827 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.01 | 2483.0 | 3974.5 | 1175.8 | -2.0 | 0.530 | 0.625 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.032 | 1873.3 | 3974.5 | 1175.8 | -1.49 | 0.303 | 0.471 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.1 | 1516.3 | 3974.5 | 1175.8 | -1.0 | 0.156 | 0.381 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 0.32 | 1312.5 | 3974.5 | 1175.8 | -0.495 | 0.065 | 0.330 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 1.0 | 1230.0 | 3974.5 | 1175.8 | 0.0 | 0.026 | 0.309 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin1 | 3 | 72 | 3.2 | 1337.3 | 3974.5 | 1175.8 | 0.505 | 0.076 | 0.336 | 1.757 | BT549 Torin1 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.001 | 3237.5 | 3597.8 | 1175.8 | -3.0 | 0.873 | 0.900 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.0032 | 2504.5 | 3597.8 | 1175.8 | -2.49 | 0.598 | 0.696 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.01 | 2004.5 | 3597.8 | 1175.8 | -2.0 | 0.392 | 0.557 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.032 | 1697.8 | 3597.8 | 1175.8 | -1.49 | 0.256 | 0.472 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.1 | 1427.3 | 3597.8 | 1175.8 | -1.0 | 0.128 | 0.397 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 0.32 | 1119.5 | 3597.8 | 1175.8 | -0.495 | -0.030 | 0.311 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 1.0 | 801.3 | 3597.8 | 1175.8 | 0.0 | -0.212 | 0.223 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Torin2 | 3 | 72 | 3.2 | 733.3 | 3597.8 | 1175.8 | 0.505 | -0.254 | 0.204 | 1.613 | BT549 Torin2 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 0.001 | 3719.0 | 3968.8 | 1175.8 | -3.0 | 0.927 | 0.937 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 0.0032 | 3731.8 | 3968.8 | 1175.8 | -2.49 | 0.931 | 0.940 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 0.01 | 3737.8 | 3968.8 | 1175.8 | -2.0 | 0.933 | 0.942 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 0.032 | 3599.5 | 3968.8 | 1175.8 | -1.49 | 0.892 | 0.907 | 1.755 | BT549 Trametinib 0 3 72 |
| BT-549 | Trametinib | 3 | 72 | 0.1 | 3315.5 | 3968.8 | 1175.8 | -1.0 | 0.805 | 0.835 | 1.755 | BT549 Trametinib 0 3 72 |