Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 AS605240 2 72
3.2
 4447.0 4866.0 1249.6
0.505
 0.910 0.914 1.961
BT549 AS605240 0 2 72
BT-549 AZD-6482 2 72
0.001
 4957.0 4904.3 1249.6
-3.0
 1.010 1.010 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
0.0032
 4612.3 4904.3 1249.6
-2.49
 0.939 0.940 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
0.01
 4754.3 4904.3 1249.6
-2.0
 0.969 0.969 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
0.032
 4718.3 4904.3 1249.6
-1.49
 0.961 0.962 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
0.1
 4320.3 4904.3 1249.6
-1.0
 0.876 0.881 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
0.32
 4192.3 4904.3 1249.6
-0.495
 0.847 0.855 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
1.0
 4006.3 4904.3 1249.6
0.0
 0.805 0.817 1.973
BT549 AZD6482 0 2 72
BT-549 AZD-6482 2 72
3.2
 3294.8 4904.3 1249.6
0.505
 0.635 0.672 1.973
BT549 AZD6482 0 2 72
BT-549 AZD8055 2 72
0.001
 4481.3 4500.0 1249.6
-3.0
 0.995 0.996 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
0.0032
 4117.5 4500.0 1249.6
-2.49
 0.906 0.915 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
0.01
 3775.5 4500.0 1249.6
-2.0
 0.819 0.839 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
0.032
 2828.5 4500.0 1249.6
-1.49
 0.556 0.629 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
0.1
 1982.3 4500.0 1249.6
-1.0
 0.284 0.441 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
0.32
 1583.8 4500.0 1249.6
-0.495
 0.137 0.352 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
1.0
 1721.3 4500.0 1249.6
0.0
 0.189 0.383 1.848
BT549 AZD8055 0 2 72
BT-549 AZD8055 2 72
3.2
 1591.7 4500.0 1249.6
0.505
 0.140 0.354 1.848
BT549 AZD8055 0 2 72
BT-549 Dactolisib 2 72
0.001
 4397.5 4628.8 1249.6
-3.0
 0.946 0.950 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
0.0032
 3978.3 4628.8 1249.6
-2.49
 0.846 0.859 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
0.01
 2450.3 4628.8 1249.6
-2.0
 0.428 0.529 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
0.032
 1887.5 4628.8 1249.6
-1.49
 0.244 0.408 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
0.1
 1590.0 4628.8 1249.6
-1.0
 0.136 0.344 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
0.32
 1478.0 4628.8 1249.6
-0.495
 0.093 0.319 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
1.0
 1361.5 4628.8 1249.6
0.0
 0.047 0.294 1.889
BT549 BEZ235 0 2 72
BT-549 Dactolisib 2 72
3.2
 1229.3 4628.8 1249.6
0.505
 -0.009 0.266 1.889
BT549 BEZ235 0 2 72