Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 Buparlisib 2 72
0.001
 4880.3 4705.0 1249.6
-3.0
 1.040 1.040 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
0.0032
 4878.5 4705.0 1249.6
-2.49
 1.040 1.040 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
0.01
 4840.3 4705.0 1249.6
-2.0
 1.030 1.030 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
0.032
 4714.5 4705.0 1249.6
-1.49
 1.000 1.000 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
0.1
 4559.3 4705.0 1249.6
-1.0
 0.967 0.969 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
0.32
 3855.0 4705.0 1249.6
-0.495
 0.802 0.819 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
1.0
 1997.5 4705.0 1249.6
0.0
 0.278 0.425 1.913
BT549 BKM120 0 2 72
BT-549 Buparlisib 2 72
3.2
 621.8 4705.0 1249.6
0.505
 -0.306 0.132 1.913
BT549 BKM120 0 2 72
BT-549 BX-912 2 72
0.001
 4862.3 4820.0 1249.6
-3.0
 1.010 1.010 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
0.0032
 4507.5 4820.0 1249.6
-2.49
 0.932 0.935 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
0.01
 4789.0 4820.0 1249.6
-2.0
 0.993 0.994 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
0.032
 4778.0 4820.0 1249.6
-1.49
 0.991 0.991 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
0.1
 4805.8 4820.0 1249.6
-1.0
 0.997 0.997 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
0.32
 4857.5 4820.0 1249.6
-0.495
 1.010 1.010 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
1.0
 2845.8 4820.0 1249.6
0.0
 0.526 0.590 1.948
BT549 BX912 0 2 72
BT-549 BX-912 2 72
3.2
 2176.3 4820.0 1249.6
0.505
 0.330 0.452 1.948
BT549 BX912 0 2 72
BT-549 Alpelisib 2 72
0.001
 5072.5 4752.0 1249.6
-3.0
 1.070 1.070 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
0.0032
 4897.0 4752.0 1249.6
-2.49
 1.030 1.030 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
0.01
 4783.8 4752.0 1249.6
-2.0
 1.010 1.010 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
0.032
 4410.5 4752.0 1249.6
-1.49
 0.924 0.928 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
0.1
 4482.5 4752.0 1249.6
-1.0
 0.940 0.943 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
0.32
 4462.5 4752.0 1249.6
-0.495
 0.936 0.939 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
1.0
 4414.5 4752.0 1249.6
0.0
 0.925 0.929 1.927
BT549 BYL719 0 2 72
BT-549 Alpelisib 2 72
3.2
 4012.0 4752.0 1249.6
0.505
 0.832 0.844 1.927
BT549 BYL719 0 2 72
BT-549 CAL-101 2 72
0.001
 4756.0 4911.3 1249.6
-3.0
 0.968 0.968 1.975
BT549 CAL101 0 2 72