Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | Everolimus | 3 | 72 | 0.0032 | 2487.8 | 3532.8 | 1175.8 | -2.49 | 0.603 | 0.704 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 0.01 | 2429.8 | 3532.8 | 1175.8 | -2.0 | 0.580 | 0.688 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 0.032 | 2465.5 | 3532.8 | 1175.8 | -1.49 | 0.594 | 0.698 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 0.1 | 2415.5 | 3532.8 | 1175.8 | -1.0 | 0.574 | 0.684 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 0.32 | 2305.8 | 3532.8 | 1175.8 | -0.495 | 0.529 | 0.653 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 1.0 | 2406.0 | 3532.8 | 1175.8 | 0.0 | 0.570 | 0.681 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Everolimus | 3 | 72 | 3.2 | 2316.3 | 3532.8 | 1175.8 | 0.505 | 0.533 | 0.656 | 1.587 | BT549 Everolimus 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.001 | 4004.0 | 4002.3 | 1175.8 | -3.0 | 1.000 | 1.000 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.0032 | 3936.0 | 4002.3 | 1175.8 | -2.49 | 0.981 | 0.983 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.01 | 3887.8 | 4002.3 | 1175.8 | -2.0 | 0.967 | 0.971 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.032 | 3798.5 | 4002.3 | 1175.8 | -1.49 | 0.942 | 0.949 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.1 | 3735.3 | 4002.3 | 1175.8 | -1.0 | 0.923 | 0.933 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 0.32 | 3271.3 | 4002.3 | 1175.8 | -0.495 | 0.784 | 0.817 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 1.0 | 2644.5 | 4002.3 | 1175.8 | 0.0 | 0.582 | 0.661 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | Pictilisib | 3 | 72 | 3.2 | 1808.3 | 4002.3 | 1175.8 | 0.505 | 0.276 | 0.452 | 1.767 | BT549 GDC0941 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.001 | 3989.5 | 4100.0 | 1175.8 | -3.0 | 0.970 | 0.973 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.0032 | 3845.3 | 4100.0 | 1175.8 | -2.49 | 0.930 | 0.938 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.01 | 3989.3 | 4100.0 | 1175.8 | -2.0 | 0.970 | 0.973 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.032 | 3647.5 | 4100.0 | 1175.8 | -1.49 | 0.874 | 0.890 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.1 | 2917.8 | 4100.0 | 1175.8 | -1.0 | 0.656 | 0.712 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 0.32 | 1844.0 | 4100.0 | 1175.8 | -0.495 | 0.284 | 0.450 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 1.0 | 1506.8 | 4100.0 | 1175.8 | 0.0 | 0.148 | 0.367 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | GDC-0980 | 3 | 72 | 3.2 | 1236.5 | 4100.0 | 1175.8 | 0.505 | 0.028 | 0.302 | 1.802 | BT549 GDC0980 0 3 72 |
| BT-549 | Omipalisib | 3 | 72 | 0.001 | 3639.5 | 4029.3 | 1175.8 | -3.0 | 0.889 | 0.903 | 1.777 | BT549 GSK458 0 3 72 |
| BT-549 | Omipalisib | 3 | 72 | 0.0032 | 3287.3 | 4029.3 | 1175.8 | -2.49 | 0.784 | 0.816 | 1.777 | BT549 GSK458 0 3 72 |