Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TGX221 | 3 | 72 | 0.001 | 4078.5 | 4028.3 | 571.3 | -3.0 | 1.010 | 1.010 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.0032 | 4124.0 | 4028.3 | 571.3 | -2.49 | 1.020 | 1.020 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.01 | 4077.3 | 4028.3 | 571.3 | -2.0 | 1.010 | 1.010 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.032 | 4020.8 | 4028.3 | 571.3 | -1.49 | 0.999 | 0.998 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.1 | 3971.3 | 4028.3 | 571.3 | -1.0 | 0.990 | 0.986 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 0.32 | 3892.8 | 4028.3 | 571.3 | -0.495 | 0.976 | 0.966 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 1.0 | 3806.3 | 4028.3 | 571.3 | 0.0 | 0.960 | 0.945 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | TGX221 | 3 | 72 | 3.2 | 3409.0 | 4028.3 | 571.3 | 0.505 | 0.885 | 0.846 | 2.818 | Hs578T TGX221 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.001 | 4036.8 | 4147.8 | 571.3 | -3.0 | 0.981 | 0.973 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.0032 | 3400.5 | 4147.8 | 571.3 | -2.49 | 0.866 | 0.820 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.01 | 2675.8 | 4147.8 | 571.3 | -2.0 | 0.716 | 0.645 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.032 | 1795.8 | 4147.8 | 571.3 | -1.49 | 0.492 | 0.433 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.1 | 1264.3 | 4147.8 | 571.3 | -1.0 | 0.320 | 0.305 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 0.32 | 1032.5 | 4147.8 | 571.3 | -0.495 | 0.230 | 0.249 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 1.0 | 963.3 | 4147.8 | 571.3 | 0.0 | 0.200 | 0.232 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin1 | 3 | 72 | 3.2 | 903.8 | 4147.8 | 571.3 | 0.505 | 0.174 | 0.218 | 2.860 | Hs578T Torin1 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.001 | 3608.8 | 4103.3 | 571.3 | -3.0 | 0.912 | 0.879 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.0032 | 3035.3 | 4103.3 | 571.3 | -2.49 | 0.799 | 0.740 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.01 | 2242.0 | 4103.3 | 571.3 | -2.0 | 0.617 | 0.546 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.032 | 1613.3 | 4103.3 | 571.3 | -1.49 | 0.440 | 0.393 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.1 | 1072.5 | 4103.3 | 571.3 | -1.0 | 0.248 | 0.261 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 0.32 | 750.0 | 4103.3 | 571.3 | -0.495 | 0.100 | 0.183 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 1.0 | 337.8 | 4103.3 | 571.3 | 0.0 | -0.169 | 0.082 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Torin2 | 3 | 72 | 3.2 | 185.0 | 4103.3 | 571.3 | 0.505 | -0.327 | 0.045 | 2.844 | Hs578T Torin2 3 |
| Hs 578T | Trametinib | 3 | 72 | 0.001 | 3280.0 | 4062.0 | 571.3 | -3.0 | 0.854 | 0.807 | 2.830 | Hs578T Trametinib 3 |