Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | MK2206 | 3 | 72 | 3.2 | 3111.8 | 4213.3 | 571.3 | 0.505 | 0.800 | 0.739 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | PI103 | 3 | 72 | 0.001 | 4138.5 | 3999.0 | 571.3 | -3.0 | 1.020 | 1.030 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 0.0032 | 4206.5 | 3999.0 | 571.3 | -2.49 | 1.040 | 1.050 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 0.01 | 4237.3 | 3999.0 | 571.3 | -2.0 | 1.040 | 1.060 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 0.032 | 3652.8 | 3999.0 | 571.3 | -1.49 | 0.937 | 0.913 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 0.1 | 2779.5 | 3999.0 | 571.3 | -1.0 | 0.757 | 0.695 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 0.32 | 1764.8 | 3999.0 | 571.3 | -0.495 | 0.494 | 0.441 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 1.0 | 1238.3 | 3999.0 | 571.3 | 0.0 | 0.317 | 0.310 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PI103 | 3 | 72 | 3.2 | 898.8 | 3999.0 | 571.3 | 0.505 | 0.175 | 0.225 | 2.807 | Hs578T PI103 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.001 | 4137.8 | 4023.5 | 571.3 | -3.0 | 1.020 | 1.030 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.0032 | 4040.3 | 4023.5 | 571.3 | -2.49 | 1.000 | 1.000 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.01 | 4188.3 | 4023.5 | 571.3 | -2.0 | 1.030 | 1.040 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.032 | 4105.3 | 4023.5 | 571.3 | -1.49 | 1.010 | 1.020 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.1 | 3913.0 | 4023.5 | 571.3 | -1.0 | 0.980 | 0.973 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 0.32 | 3504.5 | 4023.5 | 571.3 | -0.495 | 0.904 | 0.871 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 1.0 | 2702.5 | 4023.5 | 571.3 | 0.0 | 0.736 | 0.672 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | PIK-93 | 3 | 72 | 3.2 | 1509.5 | 4023.5 | 571.3 | 0.505 | 0.412 | 0.375 | 2.816 | Hs578T PIK93 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.001 | 2611.5 | 4078.5 | 571.3 | -3.0 | 0.709 | 0.640 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.0032 | 2520.5 | 4078.5 | 571.3 | -2.49 | 0.688 | 0.618 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.01 | 2565.0 | 4078.5 | 571.3 | -2.0 | 0.698 | 0.629 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.032 | 2591.0 | 4078.5 | 571.3 | -1.49 | 0.704 | 0.635 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.1 | 2471.0 | 4078.5 | 571.3 | -1.0 | 0.676 | 0.606 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 0.32 | 2577.0 | 4078.5 | 571.3 | -0.495 | 0.701 | 0.632 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 1.0 | 2464.8 | 4078.5 | 571.3 | 0.0 | 0.675 | 0.604 | 2.836 | Hs578T Rapamycin 3 |
| Hs 578T | Sirolimus | 3 | 72 | 3.2 | 2472.8 | 4078.5 | 571.3 | 0.505 | 0.676 | 0.606 | 2.836 | Hs578T Rapamycin 3 |