Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T Alpelisib 2 72
0.32
 2971.5 3566.3 624.7
-0.495
 0.860 0.833 2.513
Hs578T BYL719 2
Hs 578T Alpelisib 2 72
1.0
 2590.8 3566.3 624.7
0.0
 0.761 0.726 2.513
Hs578T BYL719 2
Hs 578T Alpelisib 2 72
3.2
 2260.3 3566.3 624.7
0.505
 0.668 0.634 2.513
Hs578T BYL719 2
Hs 578T CAL-101 2 72
0.001
 3567.3 3619.3 624.7
-3.0
 0.989 0.986 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
0.0032
 3546.0 3619.3 624.7
-2.49
 0.984 0.980 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
0.01
 3508.5 3619.3 624.7
-2.0
 0.976 0.969 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
0.032
 3530.8 3619.3 624.7
-1.49
 0.981 0.976 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
0.1
 3302.3 3619.3 624.7
-1.0
 0.929 0.912 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
0.32
 3290.8 3619.3 624.7
-0.495
 0.926 0.909 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
1.0
 3033.5 3619.3 624.7
0.0
 0.865 0.838 2.534
Hs578T CAL101 2
Hs 578T CAL-101 2 72
3.2
 2774.0 3619.3 624.7
0.505
 0.801 0.766 2.534
Hs578T CAL101 2
Hs 578T Everolimus 2 72
0.001
 2538.0 3659.5 624.7
-3.0
 0.733 0.694 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
0.0032
 2398.8 3659.5 624.7
-2.49
 0.695 0.655 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
0.01
 2260.0 3659.5 624.7
-2.0
 0.656 0.618 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
0.032
 2294.0 3659.5 624.7
-1.49
 0.665 0.627 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
0.1
 2328.8 3659.5 624.7
-1.0
 0.675 0.636 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
0.32
 2244.8 3659.5 624.7
-0.495
 0.651 0.613 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
1.0
 2192.3 3659.5 624.7
0.0
 0.636 0.599 2.550
Hs578T Everolimus 2
Hs 578T Everolimus 2 72
3.2
 2159.0 3659.5 624.7
0.505
 0.626 0.590 2.550
Hs578T Everolimus 2
Hs 578T Pictilisib 2 72
0.001
 3268.5 3563.3 624.7
-3.0
 0.932 0.917 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
0.0032
 3534.0 3563.3 624.7
-2.49
 0.993 0.992 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
0.01
 3475.0 3563.3 624.7
-2.0
 0.980 0.975 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
0.032
 3188.3 3563.3 624.7
-1.49
 0.913 0.895 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
0.1
 2721.5 3563.3 624.7
-1.0
 0.797 0.764 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
0.32
 2301.5 3563.3 624.7
-0.495
 0.681 0.646 2.512
Hs578T GDC0941 2