Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | WYE-125132 | 1 | 72 | 0.01 | 2738.8 | 3529.8 | 873.1 | -2.0 | 0.763 | 0.776 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.032 | 1941.8 | 3529.8 | 873.1 | -1.49 | 0.487 | 0.550 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.1 | 1440.8 | 3529.8 | 873.1 | -1.0 | 0.282 | 0.408 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.32 | 1144.5 | 3529.8 | 873.1 | -0.495 | 0.144 | 0.324 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 1.0 | 982.0 | 3529.8 | 873.1 | 0.0 | 0.060 | 0.278 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 3.2 | 1021.0 | 3529.8 | 873.1 | 0.505 | 0.081 | 0.289 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | XL147 | 1 | 72 | 0.001 | 3279.5 | 3524.5 | 873.1 | -3.0 | 0.930 | 0.930 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.0032 | 3642.0 | 3524.5 | 873.1 | -2.49 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.01 | 3634.8 | 3524.5 | 873.1 | -2.0 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.032 | 3640.8 | 3524.5 | 873.1 | -1.49 | 1.030 | 1.030 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.1 | 3484.3 | 3524.5 | 873.1 | -1.0 | 0.989 | 0.989 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 0.32 | 3396.3 | 3524.5 | 873.1 | -0.495 | 0.964 | 0.964 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 1.0 | 3408.8 | 3524.5 | 873.1 | 0.0 | 0.967 | 0.967 | 2.013 | Hs578T XL147 1 |
| Hs 578T | XL147 | 1 | 72 | 3.2 | 3463.8 | 3524.5 | 873.1 | 0.505 | 0.983 | 0.983 | 2.013 | Hs578T XL147 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.001 | 3593.3 | 3415.3 | 873.1 | -3.0 | 1.050 | 1.050 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.0032 | 3578.3 | 3415.3 | 873.1 | -2.49 | 1.050 | 1.050 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.01 | 3371.8 | 3415.3 | 873.1 | -2.0 | 0.987 | 0.987 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.032 | 3062.8 | 3415.3 | 873.1 | -1.49 | 0.892 | 0.897 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.1 | 2329.3 | 3415.3 | 873.1 | -1.0 | 0.647 | 0.682 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 0.32 | 1950.0 | 3415.3 | 873.1 | -0.495 | 0.504 | 0.571 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 1.0 | 1627.5 | 3415.3 | 873.1 | 0.0 | 0.372 | 0.477 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | ZSTK474 | 1 | 72 | 3.2 | 1124.0 | 3415.3 | 873.1 | 0.505 | 0.137 | 0.329 | 1.968 | Hs578T ZSTK474 1 |
| Hs 578T | AS605240 | 2 | 72 | 0.001 | 3379.5 | 3652.0 | 624.7 | -3.0 | 0.940 | 0.925 | 2.547 | Hs578T AS605240 2 |
| Hs 578T | AS605240 | 2 | 72 | 0.0032 | 3480.8 | 3652.0 | 624.7 | -2.49 | 0.963 | 0.953 | 2.547 | Hs578T AS605240 2 |
| Hs 578T | AS605240 | 2 | 72 | 0.01 | 3386.5 | 3652.0 | 624.7 | -2.0 | 0.942 | 0.927 | 2.547 | Hs578T AS605240 2 |