Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Torin1 | 1 | 72 | 0.0032 | 2947.3 | 3386.5 | 873.1 | -2.49 | 0.863 | 0.870 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 0.01 | 2343.3 | 3386.5 | 873.1 | -2.0 | 0.657 | 0.692 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 0.032 | 1641.3 | 3386.5 | 873.1 | -1.49 | 0.381 | 0.485 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 0.1 | 1335.3 | 3386.5 | 873.1 | -1.0 | 0.243 | 0.394 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 0.32 | 1125.0 | 3386.5 | 873.1 | -0.495 | 0.138 | 0.332 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 1.0 | 935.0 | 3386.5 | 873.1 | 0.0 | 0.036 | 0.276 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin1 | 1 | 72 | 3.2 | 904.5 | 3386.5 | 873.1 | 0.505 | 0.018 | 0.267 | 1.956 | Hs578T Torin1 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.001 | 3173.0 | 3568.0 | 873.1 | -3.0 | 0.888 | 0.889 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.0032 | 2773.5 | 3568.0 | 873.1 | -2.49 | 0.767 | 0.777 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.01 | 2055.0 | 3568.0 | 873.1 | -2.0 | 0.524 | 0.576 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.032 | 1492.5 | 3568.0 | 873.1 | -1.49 | 0.302 | 0.418 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.1 | 1140.3 | 3568.0 | 873.1 | -1.0 | 0.140 | 0.320 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 0.32 | 807.3 | 3568.0 | 873.1 | -0.495 | -0.038 | 0.226 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 1.0 | 467.0 | 3568.0 | 873.1 | 0.0 | -0.265 | 0.131 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Torin2 | 1 | 72 | 3.2 | 303.8 | 3568.0 | 873.1 | 0.505 | -0.405 | 0.085 | 2.031 | Hs578T Torin2 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.001 | 2447.0 | 3601.0 | 873.1 | -3.0 | 0.656 | 0.680 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.0032 | 1967.0 | 3601.0 | 873.1 | -2.49 | 0.488 | 0.546 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.01 | 1666.0 | 3601.0 | 873.1 | -2.0 | 0.372 | 0.463 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.032 | 1429.3 | 3601.0 | 873.1 | -1.49 | 0.273 | 0.397 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.1 | 1183.8 | 3601.0 | 873.1 | -1.0 | 0.161 | 0.329 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 0.32 | 926.5 | 3601.0 | 873.1 | -0.495 | 0.030 | 0.257 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 1.0 | 867.0 | 3601.0 | 873.1 | 0.0 | -0.003 | 0.241 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | Trametinib | 1 | 72 | 3.2 | 857.0 | 3601.0 | 873.1 | 0.505 | -0.009 | 0.238 | 2.044 | Hs578T Trametinib 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.001 | 3380.0 | 3529.8 | 873.1 | -3.0 | 0.957 | 0.958 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | WYE-125132 | 1 | 72 | 0.0032 | 3148.3 | 3529.8 | 873.1 | -2.49 | 0.890 | 0.892 | 2.015 | Hs578T WYE125132 1 |