Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Buparlisib | 3 | 72 | 0.1 | 3869.5 | 4235.0 | 571.3 | -1.0 | 0.939 | 0.914 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.32 | 3143.5 | 4235.0 | 571.3 | -0.495 | 0.804 | 0.742 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 1.0 | 1442.8 | 4235.0 | 571.3 | 0.0 | 0.378 | 0.341 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 3.2 | 115.3 | 4235.0 | 571.3 | 0.505 | -0.425 | 0.027 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.001 | 4175.8 | 3993.8 | 571.3 | -3.0 | 1.030 | 1.050 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.0032 | 4202.0 | 3993.8 | 571.3 | -2.49 | 1.040 | 1.050 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.01 | 4285.5 | 3993.8 | 571.3 | -2.0 | 1.050 | 1.070 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.032 | 4271.3 | 3993.8 | 571.3 | -1.49 | 1.050 | 1.070 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.1 | 4017.5 | 3993.8 | 571.3 | -1.0 | 1.000 | 1.010 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.32 | 3679.8 | 3993.8 | 571.3 | -0.495 | 0.942 | 0.921 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 1.0 | 1860.5 | 3993.8 | 571.3 | 0.0 | 0.523 | 0.466 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 3.2 | 591.0 | 3993.8 | 571.3 | 0.505 | 0.012 | 0.148 | 2.805 | Hs578T BX912 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.001 | 4208.5 | 4137.8 | 571.3 | -3.0 | 1.010 | 1.020 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.0032 | 4164.3 | 4137.8 | 571.3 | -2.49 | 1.000 | 1.010 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.01 | 4273.3 | 4137.8 | 571.3 | -2.0 | 1.020 | 1.030 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.032 | 3790.5 | 4137.8 | 571.3 | -1.49 | 0.940 | 0.916 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.1 | 3935.8 | 4137.8 | 571.3 | -1.0 | 0.965 | 0.951 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 0.32 | 3419.0 | 4137.8 | 571.3 | -0.495 | 0.871 | 0.826 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 1.0 | 3087.3 | 4137.8 | 571.3 | 0.0 | 0.805 | 0.746 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | Alpelisib | 3 | 72 | 3.2 | 2652.0 | 4137.8 | 571.3 | 0.505 | 0.712 | 0.641 | 2.856 | Hs578T BYL719 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.001 | 4189.5 | 4189.5 | 571.3 | -3.0 | 1.000 | 1.000 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.0032 | 4192.0 | 4189.5 | 571.3 | -2.49 | 1.000 | 1.000 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.01 | 4238.3 | 4189.5 | 571.3 | -2.0 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.032 | 4226.0 | 4189.5 | 571.3 | -1.49 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |
| Hs 578T | CAL-101 | 3 | 72 | 0.1 | 4231.8 | 4189.5 | 571.3 | -1.0 | 1.010 | 1.010 | 2.874 | Hs578T CAL101 3 |