Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF7 | GSK2334470 | 3.397326315 | 0.2955 | 0.2507 | 120.0410 | -1.0000 | 0.3082 | 0.7269 | 9e-08 |
| MDA-MB-436 | Alvocidib | 0.162293194 | -0.0744 | 0.2528 | 0.1693 | -0.0464 | 2.0866 | 0.9251 | 8.55e-15 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| HCC1143 | Ribociclib | 3.643695147 | 0.3009 | 0.2535 | 264.9902 | -1.0000 | 0.2563 | 0.8300 | 2.41e-10 |
| CAMA-1 | THZ531 | 0.137279719 | -0.3792 | 0.2548 | 0.1832 | -0.4135 | 2.0894 | 0.8990 | 3.6e-13 |
| Hs 578T | Alvocidib | 0.148558558 | -0.2518 | 0.2560 | 0.2079 | -0.3548 | 1.5955 | 0.9912 | 1.11e-16 |
| MCF7 | Senexin B | 13.10460323 | 0.4652 | 0.2569 | 1000.0000 | -0.6830 | 0.1987 | 0.6278 | 4.31e-06 |
| SUM159PT | MK 1775 | 2.079002463 | -0.1602 | 0.2571 | 9.8880 | -1.0000 | 0.7045 | 0.8868 | 1.5e-12 |
| CAMA-1 | Ulixertinib | 2.566161953 | 0.1288 | 0.2586 | 42.4009 | -1.0000 | 0.3917 | 0.5616 | 3.34e-05 |
| HCC1806 | Alvocidib | 0.165238718298 | -0.4850 | 0.2588 | 0.4377 | -1.0000 | 1.1279 | 0.9859 | 1.11022302463e-16 |
| MDA-MB-453 | AZD5363 | 1.537709354 | 0.1686 | 0.2591 | 1.2036 | 0.0741 | 0.6549 | 0.8588 | 2.35e-11 |
| CAL-85-1 | SHP099 | inf | 0.5820 | 0.2604 | 0.0000 | 0.8282 | 0.0100 | 0.0000 | 1.0 |
| MDA-MB-453 | Alvocidib | 0.131746612 | -0.1949 | 0.2615 | 0.1512 | -0.1882 | 2.3212 | 0.9251 | 8.55e-15 |
| MDA-MB-453 | GSK2334470 | 2.045052119 | 0.1203 | 0.2628 | 36.8285 | -1.0000 | 0.3800 | 0.7865 | 4.15e-09 |
| HCC1937 | Senexin B | 5.024951315 | 0.4311 | 0.2642 | 1000.0000 | -0.9063 | 0.1954 | 0.7116 | 1.77e-07 |
| MDA-MB-468 | Ulixertinib | 1.621194239 | 0.3429 | 0.2660 | 0.2539 | 0.3452 | 0.6324 | 0.9377 | 8.88e-16 |
| CAL-120 | Ribociclib | inf | 0.6501 | 0.2665 | 0.0400 | 0.5150 | 0.2263 | 0.7456 | 3.71e-08 |
| MCF 10A | Ulixertinib | 1.461707314 | 0.2159 | 0.2704 | 2.7171 | -0.1676 | 0.4662 | 0.9511 | 1.11e-16 |
| HCC70 | AZD6738 | 1.73555477677 | -0.5435 | 0.2705 | 4.4527 | -1.0000 | 1.1660 | 0.9336 | 1.88737914186e-15 |
| HCC1395 | Senexin B | 6.42808065 | 0.2209 | 0.2748 | 810.0166 | -1.0000 | 0.2272 | 0.4287 | 0.000912711 |
| CAL-85-1 | Rucaparib | 15.9069887 | 0.3496 | 0.2765 | 1000.0000 | -0.6758 | 0.2065 | 0.3127 | 0.009204617 |
| BT-20 | Senexin B | 2.23064370113 | 0.0956 | 0.2772 | 71.2131 | -1.0000 | 0.3172 | 0.7918 | 3.02648173189e-09 |
| HCC1806 | AZD6738 | 1.14078689634 | -0.2827 | 0.2797 | 3.6562 | -0.8273 | 0.8382 | 0.9812 | 1.11022302463e-16 |
| HCC38 | Alvocidib | 0.139603749 | -0.4046 | 0.2799 | 0.3955 | -0.9001 | 0.9887 | 0.9746 | 1.11e-16 |
| MDA-MB-468 | Senexin B | 1.994645521 | 0.1170 | 0.2810 | 51.8931 | -1.0000 | 0.3371 | 0.8162 | 6.38e-10 |