Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | AZD2014 | 0.0339995540258 | 0.0229 | 0.5840 | 1.3220 | -0.5671 | 0.2071 | 0.8957 | 5.35460564777e-13 |
| MDA-MB-134-VI | AZD2014 | -inf | -0.7122 | ||||||
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HME1 | AZD2014 | 0.017460717 | 0.1122 | 0.5969 | 0.3948 | -0.3458 | 0.1686 | 0.9585 | 1.11e-16 |
| HCC1806 | AZD2014 | 1.79837045193 | 0.3811 | 0.3438 | 2.3555 | -0.0311 | 0.2238 | 0.8823 | 2.43538522682e-12 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| MCF7 | AZD2014 | 3.5e-06 | -0.0241 | 0.8202 | 0.0000 | -0.1837 | 0.1224 | 0.6911 | 4.19e-07 |
| CAL-120 | AZD2014 | 0.180566054 | 0.2238 | 0.4601 | 0.3048 | -0.0864 | 0.3044 | 0.9313 | 2.89e-15 |
| BT-549 | AZD2014 | 0.149914841094 | 0.0235 | 0.4823 | 23.5998 | -1.0000 | 0.2172 | 0.9241 | 1.01030295241e-14 |
| SUM159PT | AZD2014 | 0.175359057 | 0.0970 | 0.4747 | 4.2801 | -0.5797 | 0.2409 | 0.9735 | 1.11e-16 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| MDA-MB-468 | AZD2014 | 0.530882864 | 0.1867 | 0.3912 | 8.6918 | -0.5185 | 0.2545 | 0.9132 | 5.41e-14 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| MDA-MB-157 | AZD2014 | 0.179038009 | 0.0326 | 0.4811 | 86.6841 | -1.0000 | 0.1777 | 0.5582 | 3.68e-05 |
| AU565 | AZD2014 | 0.003613668 | 0.0045 | 0.7508 | 0.0061 | -0.0974 | 0.3356 | 0.9277 | 5.44e-15 |
| MDA-MB-436 | AZD2014 | 55.44671225 | 0.5016 | 0.3680 | 0.0057 | 0.4275 | 0.2102 | 0.5733 | 2.38e-05 |
| T47D | AZD2014 | 3.57e-05 | -0.0845 | 0.9793 | 0.0001 | -0.1251 | 0.2870 | 0.8093 | 1.01e-09 |
| HCC70 | AZD2014 | 0.000212092429893 | 0.0222 | 0.7748 | 0.0025 | -0.2340 | 0.1552 | 0.8423 | 9.37158128878e-11 |
| SUM1315MO2 | AZD5363 | inf | 0.5993 | 0.2010 | 0.1377 | 0.6619 | 0.3406 | 0.2935 | 0.013005042 |
| MCF 10A | AZD5363 | inf | 0.6025 | 0.2092 | 0.0802 | 0.5789 | 0.3665 | 0.9389 | 6.66e-16 |
| HCC1937 | AZD5363 | 12.85319785 | 0.4773 | 0.3596 | 0.0112 | 0.4671 | 0.3863 | 0.5345 | 7.07e-05 |
| HCC1419 | AZD5363 | 51.76366593 | 0.5451 | 0.2255 | 1.6243 | 0.3603 | 0.3683 | 0.5133 | 0.000123219 |
| MDA-MB-157 | AZD5363 | inf | 0.6671 | 0.0508 | 0.0000 | 0.9480 | 0.0100 | 0.0000 | 0.135243927 |
| SK-BR-3 | AZD5363 | 2.994609539 | 0.1329 | 0.2481 | 27.0282 | -1.0000 | 0.4994 | 0.6540 | 1.73e-06 |
| CAL-85-1 | AZD5363 | inf | 0.2770 | 0.1987 | 0.0000 | 0.8552 | 0.0100 | 0.0000 | 0.179970694 |