Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | THZ531 | 0.027601073 | -0.5305 | 0.6318 | 0.0328 | -0.6914 | 5.0000 | 0.9478 | 1.11e-16 |
| HCC1806 | THZ531 | 0.42082047888 | -0.3750 | 0.1164 | 0.6984 | -1.0000 | 2.1690 | 0.9729 | 1.11022302463e-16 |
| CAL-85-1 | THZ531 | 0.06303794 | -0.2628 | 0.4242 | 0.3186 | -0.8133 | 0.5961 | 0.6795 | 6.65e-07 |
| HCC1143 | THZ531 | 0.129709951 | -0.2293 | 0.2435 | 0.1509 | -0.2433 | 2.6173 | 0.9825 | 1.11e-16 |
| SUM149PT | THZ531 | 0.351886206 | -0.4909 | 0.1494 | 0.5549 | -0.8336 | 2.1536 | 0.9830 | 1.11e-16 |
| BT-549 | THZ531 | 0.288722955947 | -0.3189 | 0.1797 | 0.5487 | -0.8192 | 1.5112 | 0.9852 | 1.11022302463e-16 |
| SK-BR-3 | THZ531 | 0.027628212 | -0.6438 | 0.5118 | 0.0388 | -0.5253 | 2.1073 | 0.9461 | 1.11e-16 |
| CAMA-1 | THZ531 | 0.137279719 | -0.3792 | 0.2548 | 0.1832 | -0.4135 | 2.0894 | 0.8990 | 3.6e-13 |
| HCC1500 | THZ531 | -inf | -0.9990 | ||||||
| BT-20 | THZ531 | 1.39952715577 | 0.5663 | 0.0377 | 3.3807 | -1.0000 | 1.2457 | 0.6737 | 8.31588281125e-07 |
| HCC38 | Ulixertinib | 4.626845935 | 0.3500 | 0.2125 | 206.4527 | -1.0000 | 0.2892 | 0.7494 | 3.07e-08 |
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| HCC1395 | Ulixertinib | 1.871580782 | 0.1659 | 0.2498 | 4.1054 | -0.2114 | 0.4489 | 0.7753 | 7.87e-09 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| T47D | Ulixertinib | 3.528421043 | 0.1952 | 0.2003 | 28.8265 | -1.0000 | 0.5230 | 0.8600 | 2.12e-11 |
| CAL-85-1 | Ulixertinib | 3.83746694 | 0.2311 | 0.2960 | 72.1557 | -1.0000 | 0.3744 | 0.3008 | 0.011412092 |
| HCC1954 | Ulixertinib | 2.75874205583 | 0.2574 | 0.2843 | 57.3582 | -1.0000 | 0.3620 | 0.7744 | 8.25544232974e-09 |
| HCC1419 | Ulixertinib | 15.03549958 | 0.5776 | 0.0806 | 48.1146 | -1.0000 | 0.9445 | 0.5529 | 4.27e-05 |
| SUM159PT | Ulixertinib | 1.943050817 | 0.1333 | 0.2476 | 22.3099 | -1.0000 | 0.4501 | 0.9582 | 1.11e-16 |
| HCC1428 | Ulixertinib | 0.227625258 | 0.1375 | 0.4320 | 0.1734 | 0.1614 | 1.4315 | 0.2319 | 0.036949884 |
| SUM149PT | Ulixertinib | 2.037761408 | 0.1734 | 0.2350 | 4.8956 | -0.2916 | 0.5241 | 0.9161 | 3.52e-14 |
| HCC70 | Ulixertinib | 1.412958526 | 0.3819 | 0.2819 | 0.0475 | 0.4787 | 0.9295 | 0.8473 | 6.27075058546e-11 |
| CAL-51 | Ulixertinib | 20.08181132 | 0.7439 | 0.0569 | 48.1868 | -0.9997 | 1.2549 | 0.4674 | 0.000380369 |
| HCC1500 | Ulixertinib | -inf | 0.3396 | ||||||
| MCF 10A | Ulixertinib | 1.461707314 | 0.2159 | 0.2704 | 2.7171 | -0.1676 | 0.4662 | 0.9511 | 1.11e-16 |