Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HME1 | Alvocidib | 0.114196744 | -0.3549 | 0.3125 | 0.4526 | -1.0000 | 0.7978 | 0.9854 | 1.11e-16 |
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| HCC1419 | Alvocidib | 0.180879399 | -0.2626 | 0.2408 | 0.5478 | -0.8902 | 0.9228 | 0.9420 | 3.33e-16 |
| HCC1395 | Alvocidib | 0.123109246 | -0.6242 | 0.3359 | 0.3193 | -1.0000 | 1.1526 | 0.9075 | 1.2e-13 |
| SK-BR-3 | Alvocidib | 0.138970351 | -0.7648 | 0.3411 | 0.3016 | -1.0000 | 1.4181 | 0.9513 | 1.11e-16 |
| MDA-MB-157 | Alvocidib | 0.152222738 | -0.8658 | 0.2879 | 0.2794 | -1.0000 | 1.8087 | 0.9385 | 7.77e-16 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| SUM1315MO2 | Alvocidib | 0.111817025 | -0.7885 | 0.3864 | 0.2928 | -1.0000 | 1.1414 | 0.9268 | 6.44e-15 |
| HCC1143 | AZD2014 | 0.421624866 | 0.1334 | 0.3982 | 59.1681 | -1.0000 | 0.2222 | 0.9449 | 2.22e-16 |
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| SUM1315MO2 | AZD2014 | 0.001390649 | 0.0852 | 0.6690 | 6.8904 | -0.6708 | 0.1000 | 0.3997 | 0.001697935 |
| CAL-85-1 | AZD2014 | 0.006143702 | 0.1542 | 0.6519 | 0.0034 | 0.0732 | 0.2721 | 0.6523 | 1.84e-06 |
| HCC38 | AZD2014 | 0.444460248 | 0.1801 | 0.4094 | 63.7169 | -1.0000 | 0.2213 | 0.8924 | 7.9e-13 |
| SUM149PT | AZD2014 | 1.870533874 | 0.3557 | 0.3916 | 1000.0000 | -0.6285 | 0.1296 | 0.8137 | 7.57e-10 |
| MDA-MB-468 | AZD2014 | 0.530882864 | 0.1867 | 0.3912 | 8.6918 | -0.5185 | 0.2545 | 0.9132 | 5.41e-14 |
| MCF7 | AZD2014 | 3.5e-06 | -0.0241 | 0.8202 | 0.0000 | -0.1837 | 0.1224 | 0.6911 | 4.19e-07 |
| SK-BR-3 | AZD2014 | 1.21e-05 | -0.0787 | 0.8687 | 0.0006 | -0.3127 | 0.1272 | 0.7038 | 2.48e-07 |
| MDA-MB-436 | AZD2014 | 55.44671225 | 0.5016 | 0.3680 | 0.0057 | 0.4275 | 0.2102 | 0.5733 | 2.38e-05 |
| HCC1428 | AZD2014 | 2.19e-05 | -0.5555 | 1.2048 | 0.0005 | -0.5838 | 0.2503 | 0.4940 | 0.000200146 |
| MCF 10A | AZD2014 | 0.030975176 | -0.1702 | 0.6409 | 4.3568 | -1.0000 | 0.2221 | 0.9310 | 3.11e-15 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| MDA-MB-361 | AZD2014 | 0.000105775 | -0.6868 | 1.1635 | 0.0173 | -1.0000 | 0.2155 | 0.9146 | 4.4e-14 |
| HCC1419 | AZD2014 | 0.000451019 | -0.1328 | 0.9581 | 0.0009 | -0.1553 | 0.4080 | 0.8343 | 1.75e-10 |
| HME1 | AZD2014 | 0.017460717 | 0.1122 | 0.5969 | 0.3948 | -0.3458 | 0.1686 | 0.9585 | 1.11e-16 |