Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | BMS-265246 | 0.001767259 | -0.0571 | 0.8227 | 0.0030 | -0.1138 | 0.3912 | 0.9074 | 1.21e-13 |
| MDA-MB-468 | GSK2334470 | 10.51361506 | 0.4709 | 0.0792 | 20.7908 | -0.9912 | 1.6026 | 0.6636 | 1.22e-06 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| HCC1500 | LY3023414 | 2.44e-06 | -0.9965 | 1.9835 | 0.0000 | -0.9955 | 0.7773 | 0.6628 | 1.25e-06 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| CAMA-1 | AZD5363 | 0.048497519 | -0.1534 | 0.5494 | 10.8262 | -1.0000 | 0.2031 | 0.8383 | 1.28e-10 |
| MDA-MB-361 | LY3023414 | 1.3e-05 | -0.9848 | 1.4263 | 0.0014 | -1.0000 | 0.2362 | 0.9070 | 1.28e-13 |
| CAL-85-1 | MK 1775 | 0.182874423 | -0.5298 | 0.5409 | 3.0854 | -1.0000 | 0.3888 | 0.7205 | 1.2e-07 |
| CAL-85-1 | LY3023414 | 0.000296659 | -0.1414 | 0.7983 | 0.0033 | -0.2397 | 0.1626 | 0.7206 | 1.2e-07 |
| HCC1395 | Alvocidib | 0.123109246 | -0.6242 | 0.3359 | 0.3193 | -1.0000 | 1.1526 | 0.9075 | 1.2e-13 |
| SUM149PT | Ribociclib | 229.6984296 | 0.5649 | 0.1855 | 1.4808 | 0.4031 | 0.3252 | 0.8653 | 1.31e-11 |
| T47D | Alvocidib | 0.115068759 | -0.1548 | 0.2473 | 0.2275 | -0.4346 | 0.9177 | 0.9066 | 1.35e-13 |
| HCC1954 | MK 1775 | 1.30961385046 | -0.4209 | 0.3053 | 5.8191 | -1.0000 | 0.7366 | 0.8046 | 1.37290245839e-09 |
| MCF 10A | Senexin B | 13.2364754711 | 0.8231 | -0.0310 | 16.5655 | -1.0000 | 4.8970 | 0.5533 | 1.42287035656e-05 |
| MCF 10A | Rucaparib | 365.312204082 | 0.8656 | 0.0388 | 751.5036 | -0.2094 | 0.4850 | 0.5902 | 1.43637187561e-05 |
| HCC1954 | Senexin B | 211.891286993 | 0.4085 | 0.3284 | 0.0138 | 0.4972 | 0.5378 | 0.5891 | 1.48480209144e-05 |
| AU565 | RO-3306 | 0.451155856 | -0.1943 | 0.4065 | 23.6830 | -1.0000 | 0.2774 | 0.5910 | 1.4e-05 |
| HCC38 | Senexin B | 15.63810324 | 0.5236 | 0.1411 | 269.9088 | -0.9985 | 0.3853 | 0.5885 | 1.51e-05 |
| CAL-120 | Rucaparib | 76.53871191 | 0.5903 | 0.1235 | 1000.0000 | -0.5462 | 0.2873 | 0.7153 | 1.52e-07 |
| Hs 578T | Ribociclib | 2.691890869 | 0.3645 | 0.3425 | 1000.0000 | -0.7904 | 0.1602 | 0.9056 | 1.53e-13 |
| MDA-MB-453 | Ulixertinib | 7.626205493 | 0.3905 | 0.0734 | 22.8576 | -1.0000 | 1.0008 | 0.7623 | 1.58e-08 |
| MCF 10A | Ribociclib | 21.11238563 | 0.4876 | 0.1616 | 1000.0000 | -1.0000 | 0.2848 | 0.8863 | 1.58e-12 |
| SUM159PT | MK 1775 | 2.079002463 | -0.1602 | 0.2571 | 9.8880 | -1.0000 | 0.7045 | 0.8868 | 1.5e-12 |
| BT-549 | AZD5363 | 43.7006769506 | 0.4943 | 0.2130 | 1000.0000 | -0.4263 | 0.1970 | 0.7620 | 1.61378319596e-08 |
| HCC1143 | Senexin B | 16.15394735 | 0.4142 | 0.1852 | 1000.0000 | -0.7697 | 0.2259 | 0.6559 | 1.62e-06 |