Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC38 | THZ1 | 0.02382594 | -0.5420 | 0.5167 | 0.0405 | -0.4828 | 1.2756 | 0.9829 | 1.11e-16 |
| MDA-MB-468 | SHP099 | 15.69903996 | 0.5419 | 0.1218 | 54.5394 | -0.4817 | 0.5418 | 0.5522 | 4.35e-05 |
| SUM1315MO2 | MK 1775 | 0.00109721 | -0.6828 | 0.9928 | 0.0075 | -0.4794 | 0.3502 | 0.6449 | 2.4e-06 |
| MCF 10A | AZD2014 | 0.432150800137 | 0.0828 | 0.4111 | 4.6296 | -0.4698 | 0.2793 | 0.9640 | 1.11022302463e-16 |
| SUM149PT | THZ1 | 0.048963473 | -0.4879 | 0.4000 | 0.0794 | -0.4676 | 1.3644 | 0.9885 | 1.11e-16 |
| MDA-MB-157 | RO-3306 | 4.277636246 | -0.4568 | 0.0971 | 4.8761 | -0.4623 | 5.0000 | 0.8859 | 1.65e-12 |
| Hs 578T | MK 1775 | 0.014507078 | -0.3462 | 0.7648 | 0.0762 | -0.4564 | 0.3909 | 0.9740 | 1.11e-16 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| HCC1395 | GSK2334470 | 54.2680197 | 0.4791 | 0.2112 | 918.5477 | -0.4410 | 0.2235 | 0.3535 | 0.004287213 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| T47D | Alvocidib | 0.115068759 | -0.1548 | 0.2473 | 0.2275 | -0.4346 | 0.9177 | 0.9066 | 1.35e-13 |
| BT-549 | THZ1 | 0.0507973383595 | -0.4458 | 0.3738 | 0.0826 | -0.4271 | 1.2714 | 0.9715 | 1.11022302463e-16 |
| BT-549 | AZD5363 | 43.7006769506 | 0.4943 | 0.2130 | 1000.0000 | -0.4263 | 0.1970 | 0.7620 | 1.61378319596e-08 |
| CAMA-1 | THZ531 | 0.137279719 | -0.3792 | 0.2548 | 0.1832 | -0.4135 | 2.0894 | 0.8990 | 3.6e-13 |
| MCF7 | THZ1 | 0.022830734 | -0.4455 | 0.4917 | 0.0384 | -0.4128 | 1.1568 | 0.9820 | 1.11e-16 |
| HCC1419 | THZ1 | 0.059640487 | -0.4111 | 0.3717 | 0.0888 | -0.4101 | 1.5044 | 0.9706 | 1.11e-16 |
| HCC1806 | MK 1775 | 0.0128166062504 | -0.4617 | 0.8151 | 0.0380 | -0.4095 | 0.5503 | 0.9684 | 1.11022302463e-16 |
| CAMA-1 | BMS-265246 | 0.000235768 | -0.0623 | 0.8248 | 0.0086 | -0.4066 | 0.1654 | 0.7534 | 2.51e-08 |
| Hs 578T | LY3023414 | 0.000331352 | 0.0271 | 0.6875 | 0.1184 | -0.4001 | 0.1000 | 0.8522 | 4.17e-11 |
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| MDA-MB-453 | MK 1775 | 0.103540362 | -0.1845 | 0.5656 | 0.2626 | -0.3748 | 0.6010 | 0.9620 | 1.11e-16 |
| AU565 | BMS-265246 | 0.295937858 | -0.1432 | 0.5304 | 0.7056 | -0.3746 | 0.6436 | 0.6685 | 1.01e-06 |
| MDA-MB-436 | LY3023414 | 4.691952741 | 0.1749 | 0.3897 | 1000.0000 | -0.3698 | 0.1033 | 0.4098 | 0.001372738 |
| SUM149PT | Rucaparib | 66.68976855 | 0.5687 | 0.2055 | 1000.0000 | -0.3605 | 0.2005 | 0.6540 | 1.73e-06 |
| MDA-MB-468 | THZ1 | 0.023258754 | -0.4302 | 0.5137 | 0.0368 | -0.3586 | 1.1755 | 0.9657 | 1.11e-16 |