Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC70 | AZD5363 | 0.0251705169742 | -0.2793 | 0.6653 | 0.5821 | -0.6722 | 0.2713 | 0.8708 | 7.80986386673e-12 |
| SUM1315MO2 | AZD2014 | 0.001390649 | 0.0852 | 0.6690 | 6.8904 | -0.6708 | 0.1000 | 0.3997 | 0.001697935 |
| HCC1954 | THZ1 | 0.0965224052209 | -0.5246 | 0.2985 | 0.1858 | -0.6687 | 1.2967 | 0.9764 | 1.11022302463e-16 |
| MDA-MB-231 | THZ1 | 0.0637722395519 | -0.4824 | 0.3383 | 0.1459 | -0.6653 | 1.0222 | 0.9846 | 1.11022302463e-16 |
| MDA-MB-157 | THZ531 | 0.060618587 | -0.7599 | 0.4261 | 0.0784 | -0.6567 | 3.2544 | 0.9596 | 1.11e-16 |
| MCF 10A | THZ1 | 0.046492791 | -0.4253 | 0.4095 | 0.1201 | -0.6388 | 0.8674 | 0.9905 | 1.11e-16 |
| SUM149PT | AZD2014 | 1.870533874 | 0.3557 | 0.3916 | 1000.0000 | -0.6285 | 0.1296 | 0.8137 | 7.57e-10 |
| HCC1395 | THZ1 | 0.022043777 | -0.7138 | 0.5570 | 0.0343 | -0.6189 | 1.8271 | 0.9657 | 1.11e-16 |
| BT-549 | AZD6738 | 3.78928346904 | -0.1598 | 0.0782 | 5.9672 | -0.5898 | 1.7158 | 0.9614 | 1.11022302463e-16 |
| HCC1428 | AZD2014 | 2.19e-05 | -0.5555 | 1.2048 | 0.0005 | -0.5838 | 0.2503 | 0.4940 | 0.000200146 |
| SUM159PT | AZD2014 | 0.175359057 | 0.0970 | 0.4747 | 4.2801 | -0.5797 | 0.2409 | 0.9735 | 1.11e-16 |
| CAL-120 | MK 1775 | 0.196043462 | -0.2603 | 0.4877 | 0.9132 | -0.5740 | 0.4969 | 0.9800 | 1.11e-16 |
| HCC1954 | AZD2014 | 0.0339995540258 | 0.0229 | 0.5840 | 1.3220 | -0.5671 | 0.2071 | 0.8957 | 5.35460564777e-13 |
| HCC38 | SHP099 | 37.96041806 | 0.4903 | 0.1469 | 730.5570 | -0.5486 | 0.2504 | 0.5746 | 2.29e-05 |
| CAL-120 | Rucaparib | 76.53871191 | 0.5903 | 0.1235 | 1000.0000 | -0.5462 | 0.2873 | 0.7153 | 1.52e-07 |
| HCC1806 | GSK2334470 | 44.5159354048 | 0.8389 | 0.0198 | 86.1125 | -0.5419 | 1.1127 | 0.3134 | 0.00908806432112 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| MDA-MB-134-VI | THZ1 | 0.006632255 | -0.4554 | 0.6285 | 0.0190 | -0.5267 | 0.6824 | 0.8938 | 6.71e-13 |
| SK-BR-3 | THZ531 | 0.027628212 | -0.6438 | 0.5118 | 0.0388 | -0.5253 | 2.1073 | 0.9461 | 1.11e-16 |
| HCC1143 | Alvocidib | 0.171201738 | -0.3370 | 0.2245 | 0.2832 | -0.5220 | 1.4205 | 0.9893 | 1.11e-16 |
| MDA-MB-468 | AZD2014 | 0.530882864 | 0.1867 | 0.3912 | 8.6918 | -0.5185 | 0.2545 | 0.9132 | 5.41e-14 |
| AU565 | THZ1 | 0.018314242 | -0.5809 | 0.5779 | 0.0306 | -0.5110 | 1.3730 | 0.9728 | 1.11e-16 |
| HCC1143 | RO-3306 | 1.73126532 | -0.1079 | 0.2418 | 3.9460 | -0.5002 | 0.8416 | 0.9451 | 2.22e-16 |
| HCC1395 | LY3023414 | 0.006658349 | -0.1896 | 0.6194 | 2.1680 | -0.4984 | 0.1195 | 0.4950 | 0.000195378 |